In vivo biocompatibility of silicon dioxide nanofilm used as antimicrobial agent on acrylic surface

Santos, Rogério Lacerda dos; Lima, Antônia Bárbara Leite; Penha, Elizandra Silva da; Santos, Antonielson dos; Carvalho, Fabíola Galbiatti de; Pithon, Matheus Melo; Dantas, Antônio Flávio Medeiros

doi:10.1590/0001-3765202020181120

Cited by 8 publications

(11 citation statements)

References 23 publications

(12 reference statements)

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“…A recent in vivo study testing the biocompatibility of silicon dioxide nanofilm used as an antimicrobial agent on acrylic surfaces, demonstrated that coating with NP-Liquid Glass had the highest level of tissue compatibility, and the best cell repair, being highly promising for use in clinical practice. 9 In this study, it was not possible to analyze the adherence of silicon dioxide on the surface of the resin, nor the change of surface roughness. Given these limitations, the use of atomic force microscopy would be beneficial in future research, in order to analyze the surface roughness of resins and silicon dioxide adherence on the surfaces.…”

Section: Discussionmentioning

confidence: 95%

“…Furthermore, a recent in vivo study demonstrated the biocompatibility of acrylic resin coated with silicon dioxide promising be a bioprotective coating with low deleterious risk to the individual. 9 Thus, the objective of this study was to evaluate if the application of a silicon dioxide coating layer on acrylic resin commonly used on temporary partial prosthesis or complete dentures is able to reduce the Candida albicans adhesion.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Silicon dioxide coating of acrylic resin surfaces on Candida albicans adhesion

et al. 2020

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Acrylic resin has been used in the manufacture of prostheses, however, in the oral cavity, this material starts to retain microorganisms capable of causing gingival inflammation due its porosities. The aim of this study was to evaluate the influence of the use of silicon dioxide as a coating layer applied onto acrylic resin, on the adhesion of Candida albicans (Ca). After the incubation period in Sabouraud Dextrose Broth, a total of 1 ml of the Ca suspension was added to plate wells, each well containing a specimen of acrylic resin. The adhesion ability of Ca on acrylic resin was determined by counting colonies. Three groups (n = 6) of acrylic resin were assessed: with polishing (RP); without polishing (RW); with polishing and coating layer of silicon dioxide (RPC). Ca deposited on the surface of the acrylic resin was also observed using Scanning Electron Microscopy (SEM). Statistical assessment by Kruskal-Wallis and Student-Newman-Keuls Method were done (α = 2%). There was significant difference among the groups. The RPC group showed the lowest growth, with an average of 5.59 Log CFU/cm²; there was a statistically significant difference in relation to group RW, which presented a growth of 6.07 Log CFU/cm² and to group RP with 5.91 Log CFU/cm 2 (p < 000.1). SEM images demonstrated that in the RP and RPC group, the surface of the resin had greater regularity, and smaller number of microorganisms. The application of silicon dioxide coating on acrylic resin appears to be a promising alternative, and its use can help in reducing the adhesion of Ca in prostheses.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Effect of Silicon dioxide coating of acrylic resin surfaces on Candida albicans adhesion

et al. 2020

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“…Trichotomy was performed on the dorsal region 20,21 and antisepsis with CHX 4%. 22,23 Two 8-mm long and 18-mm deep incisions were made on the back of each animal. Each rat received two polyethylene tube implants (nontoxic Scalp Vein 19G) (1.5 mm internal diameter × 5.0 mm long).…”

Section: Animal Model and Experimental Groupsmentioning

confidence: 99%

Effect of Yellow Propolis on Biocompatibility of Cements: Morphological and Immunohistochemistry Analysis

et al. 2021

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Objective The focus of this study was to evaluate the biocompatibility of ionomer cements modified with ethanolic extracts of propolis (EEP) in different concentrations and time intervals. Materials and Methods In total, one hundred and thirty-five male Wistar rats were randomized into nine groups: Control, Groups Meron, and Groups Ketac (conventional, and added with 10, 25, 50% EEP, respectively). Histological analyses of inflammatory infiltrate and collagen fibers, and immunohistochemistry of CD68+ for macrophages (MOs) and multinucleated giant cells (MGCs) were performed. Statistical Analysis Data were analyzed using the Kruskal—Wallis and Dunn (p < 0.05) tests. Results Intense inflammatory infiltrate was demonstrated in the cements with 10% EEP at 7 days and 15 days (p < 0.05), only Group Ketac 10% EEP (p = 0.01) at 30 days. A smaller quantity of collagen fibers was observed in the cements with 10% EEP (p = 0.01) at 7 days, and Group Meron 10% EEP (p = 0.04) at 15 days. MOs and MGCs showed significant difference for the cements with 10% EEP (p = 0.01) at 7 and 15 days. At 30 days, MOs persisted in the Groups with 10% EEP. Conclusions The concentration of 10% EEP had the greatest influence on the inflammatory and tissue repair processes. The concentrations of 25 and 50% EEP demonstrated biocompatibility similar to that of cements that did not receive EEP.

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“…1) was amputated from the tip of the tail of the rat, in a crosscut with a size-15 scalpel blade. 21,22 Then, 1 mL of the solution was applied using a 1-mL insulin syringe attached to a 25/7 needle. The application lasted 20 seconds (►Fig.…”

Section: Surgical Proceduresmentioning

confidence: 99%

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

et al. 2021

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Objective The objective of this study was to evaluate the hemostatic activity of the sap from Jatropha mollissima (Pohl) Baill. in rats. Materials and Methods Twenty-four Wistar rats were randomized into four groups (n = 6): the JM25 and JM40 groups were treated with ethanolic extract from the sap of J. mollissima, in a concentration of 25 and 40 mg·mL1, respectively; the MO group was treated with Monsel’s solution and the control group SC with a 0.9% sodium chloride solution. Statistical Analysis Data were submitted to the Kurskal–Wallis’ test, followed by Dunn’s post hoc (p < 0.05). Results There was a significant reduction in the bleeding time of the group from the JM25 extract (p = 0.001) when compared with MO and SC. There were no statistically significant differences between groups JM25 and JM40 (p > 0.05). The JM25 group did not present rebleeding, a result significantly different from the MO group (p = 0.001). Monsel’s solution showed significant bleeding, six times greater than the control group SC. Conclusion The J. mollissima extract, in the concentration of 25 mg·mL1, showed the highest hemostatic efficiency and was found to be a promising biomaterial for the elaboration of a hemostatic product.

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In vivo biocompatibility of silicon dioxide nanofilm used as antimicrobial agent on acrylic surface

Cited by 8 publications

References 23 publications

Effect of Silicon dioxide coating of acrylic resin surfaces on Candida albicans adhesion

Effect of Silicon dioxide coating of acrylic resin surfaces on Candida albicans adhesion

Effect of Yellow Propolis on Biocompatibility of Cements: Morphological and Immunohistochemistry Analysis

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

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