Natural Products: Perspectives and Challenges for use of Brazilian Plant Species in the Bioeconomy

Valli, Marília; Bolzani, Vanderlan S.

doi:10.1590/0001-3765201920190208

Cited by 30 publications

(18 citation statements)

References 21 publications

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“…These numbers become even more impressive when considering that the knowledge about the country’s entire biodiversity is incomplete, and researchers are still working on building of this information (Filard et al 2018 ). Therefore, Brazilian flora has a rich chemical variety that makes it a potential source for drug discovery (Valli and Bolzani 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Brazilian essential oils as source for the discovery of new anti-COVID-19 drug: a review guided by in silico study

et al. 2021

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The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China and its spread worldwide has become one of the biggest health problem due to the lack of knowledge about an effective chemotherapy. Based on the current reality of the SARS-CoV-2 pandemic, this study aimed to make a review literature about potential anti-coronavirus natural compounds guided by an in silico study. In the first step, essential oils from native species found in the Brazilian herbal medicine market and Brazilian species that have already shown antiviral potential were used as source for the literature search and compounds selection. Among these compounds, 184 showed high antiviral potential against rhinovirus or picornavirus by quantitative structure–activity relationship analysis. ( E )-α-atlantone; 14-hydroxy-α-muurolene; allo-aromadendrene epoxide; amorpha-4,9-dien-2-ol; aristochene; azulenol; germacrene A; guaia-6,9-diene; hedycaryol; humulene epoxide II; α-amorphene; α-cadinene; α-calacorene and α-muurolene showed by a molecular docking study the best result for four target proteins that are essential for SARS-CoV-2 lifecycle. In addition, other parameters obtained for the selected compounds indicated low toxicity and showed good probability to achieve cell permeability and be used as a drug. These results guided the second literature search which included other species in addition to native Brazilian plants. The majority presence of any of these compounds was reported for essential oils from 45 species. In view of the few studies relating essential oils and antiviral activity, this review is important for future assays against the new coronavirus. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-021-09754-4.

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Section: Introductionmentioning

confidence: 99%

Brazilian essential oils as source for the discovery of new anti-COVID-19 drug: a review guided by in silico study

et al. 2021

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“…Brazil possesses the largest biodiversity in the world, which is a potential source for bioeconomy (Valli & Bolzani, 2019). However, only 8% of the 60,000 species of superior plants had their active compounds studied, while medicinal properties were investigated for only 1,100 species (Brazil, 2016).…”

Section: Introductionmentioning

confidence: 99%

Biological properties and phytochemical characterization from Miconia chamissois Naudin aqueous extract

Gomes¹,

Martins²,

Silva³

et al. 2021

BLACPMA

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The objective of this study was to evaluate biological and phytochemical properties of the aqueous extract from the leaves of Miconia chamissois Naudin (AEMC). Phytochemical properties were assessed by analyzing the chromatographic profile and the polyphenol content of AEMC. Biological properties evaluation was conducted based on cytotoxicity assay and by evaluating the antioxidant, antimicrobial, and enzymatic inhibition activities. Results indicated the presence of phytochemicals in AEMC such as flavonoids and polyphenols, including rutin, isoquercitrin and vitexin derivatives. AEMC showed antioxidant activity, which may be attributed to the high polyphenolic content. Moreover, AEMC demonstrated in vitro enzyme inhibition activity against tyrosinase and alpha-amylase, as well as showed low cytotoxicity. On the other hand, AEMC exhibited weak antimicrobial activity against S. aureus and C. albicans. Thus, AEMC is a promising alternative in search of potential drugs for the treatment of diseases induced by oxidative stress and inflammation, conditions due to hyperpigmentation processes, such as melisma, as well as for diabetes.

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“…Plants species have been of great importance for human development and Brazil is the country with the largest biodiversity in the world, presenting a rich chemical diversity of secondary metabolites, which is a potential source of new drugs (Valli & Bolzani, 2019). Although secondary metabolites are compounds non‐essential for plant basic vital functions, they present several pharmacological properties, including antiviral activity (Troost et al, 2020; Zakaryan et al, 2017; Zhou et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

In silico approach of secondary metabolites from Brazilian herbal medicines to search for potential drugs against SARS‐CoV‐2

Amparo

Seibert

Almeida

et al. 2021

Phytotherapy Research

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The new severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) recently emerged as a worrying pandemic, with many confirmed cases and deaths globally. Therefore, there is a clear need for identifying effective therapeutic options and a review of secondary metabolites related to Brazilian herbal medicines was performed as a strategy for the discovery of new antiviral agents. To confirm this potential, an in silico screening of the identified compounds identified was also evaluated. The review was performed by the PubMed database and the selected natural compounds were subjected to in silico analysis such as QSAR, molecular docking and ADMET. 497 secondary metabolites were identified from 23 species. The in silico assays indicated 19 potential anti‐SARS‐CoV‐2 compounds, being triterpenes and phenolic compounds. The indicated compounds showed a high affinity with proteins considered as the main molecular targets against SARS‐CoV‐2 and parameters indicated low toxicity. In addition to Brazilian medicinal plants, these compounds can be found in other species and they can be a base for the synthesis of other anti‐COVID‐19 drugs. Therefore, this review is important to conduct researches that address the emerging need for drugs in COVID‐19 treatment.

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Natural Products: Perspectives and Challenges for use of Brazilian Plant Species in the Bioeconomy

Cited by 30 publications

References 21 publications

Brazilian essential oils as source for the discovery of new anti-COVID-19 drug: a review guided by in silico study

Brazilian essential oils as source for the discovery of new anti-COVID-19 drug: a review guided by in silico study

Biological properties and phytochemical characterization from Miconia chamissois Naudin aqueous extract

In silico approach of secondary metabolites from Brazilian herbal medicines to search for potential drugs against SARS‐CoV‐2

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