Antidiarrheal effect of extract from the bark of Combretum leprosum in mice

Cavalcanti, P. M. S.; Martins, Maria do Carmo de Carvalho e; Nunes, Paulo Humberto Moreira; Filho, Francisco Chagas; Silva, Janyerson D P; Cavalcanti, Suzana Maria Galvão

doi:10.1590/0001-3765201820170932

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…(Combretaceae) is a neotropical species existent in Brazil and Paraguay (Ribeiro et al, 2020). It has wood, pharmacological, beekeeping importance and potential for restoring degraded ecosystems (Cavalcanti et al, 2019;Leal et al, 2020;Silva-Filho et al, 2020). Due to its environmental and medicinal value, studies on propagation, conservation and genetic characterization have been recommended for the survival of the species and its economic use over the next few years (Gomes-Costa and Agra, 2018).…”

Section: Introductionmentioning

confidence: 99%

Physiological and biochemical responses of “mofumbo” seeds during storage

et al. 2021

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“Mofumbo” (Combretum leprosum Mart. (Combretaceae) is a neotropical species of wood, pharmacological, beekeeping and environmental importance. Thus, the objective was to evaluate the biochemical and physiological responses in C. leprosum seeds under different storage environments. The experiment was carried out in a factorial (2 x 7), with two storage conditions (natural and climate-controlled environments) and seven storage periods (0; 60; 120; 180; 240; 300 and 360 days), in four replications per treatment. At the beginning of storage and at 60-day intervals, the seeds were analyzed for water content, physiological potential (germination, germination speed index, root and shoot lengths and seedling dry mass) and biochemical (neutral lipids, lipid peroxidation, total and reducing sugars, total free amino acids, and starch). The results indicated that storing “mofumbo” seeds for 360 days reduced viability, being more pronounced after 180 days, regardless of the storage environment. “Mofumbo” seeds were stored in a natural environment for 180 days, resulting in less lipid degradation. After this period, the reduction was associated with the attack of reducing sugars on amino acids. Thus, it is concluded that “mofumbo” seeds must be stored in a natural environment for up to 180 days.

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Section: Introductionmentioning

confidence: 99%

Physiological and biochemical responses of “mofumbo” seeds during storage

et al. 2021

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“…While the clinical manifestations of the disease vary in attendant severity and duration, the burden and economic toil it takes on affected individuals can not be overemphasized (Zimmermann et al, 2019). Some clinical manifestations of diarrhea include abdominal cramps, nausea and vomiting, which often make patients live a low-quality sedentary lifestyle (Cavalcanti et al, 2019). While contaminated food and drinks are the most renowned cause of diarrhea in humans, the effect includes an imbalance in the body electrolytes which results in hyper-secretory feedback and induction of intestinal contraction.…”

Section: Introductionmentioning

confidence: 99%

Modulatory Anti- Diarrheal Effects of Ascorbic Acid in Swiss Albino Mice

2021

KU Studies

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Ascorbic acid (AA) has been reported for the management of diarrhea. The anti-diarrheal potential and modulatory activities of AA on some commonly used anti-diarrheal drugs were investigated. For this purpose, the activities of AA on castor oil-induced diarrhea in Swiss mice were examined. As standard anti-diarrheal agents, we used prazosin, propranolol, loperamide, and nifedipine with or without AA. The results revealed that AA at 25 mg/kg (i.p.) and all other standard drugs exhibited significant (p < 0.05) diarrheal attenuating activities in mice. However, the impact was more pronounced in the loperamide and propranolol groups. AA administrated with prazosin and propranolol had a higher rate of latent periods and a lower rate of diarrheic secretion during the study period (4 h) than that of the other single or mixed groups. Furthermore, a molecular docking study illustrated that AA displayed good binding affinities with (α1) (–5.2 Kcal/mol), α2b (–5.4 Kcal/mol), α2c (-5.6 Kcal/mol), β1(–5.3 Kcal/mol) and β2(–6.4 Kcal/mol) adrenoceptors. Of note, AA exerted a significant anti-diarrheal effect and it was seen to modulate the anti-diarrheal effects of α- and β-adrenergic receptor blocking agents in Swiss mice.

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“…There are many overlapping features in diarrheal diseases that can vary in severity, duration, clinical manifestations, and sequelae according to the causal facts, which in turn can impact the economic burden on patients and their families (2). Diarrhea may also cause nausea, vomiting, and abdominal cramps, which may force affected individuals into bed rest until the hydro electrolytic balance is restored (3). The most common cause of diarrhea is an infection of the intestines due to a virus, bacterium, or parasite, or to gastroenteritis.…”

Section: Introductionmentioning

confidence: 99%

Anti-diarrheal activities of phytol along with its possible mechanism of action through in-vivo and in-silico models

Islam

Rahman

Saeed

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Phytol (PHY), a chlorophyll-derived diterpenoid, exhibits numerous pharmacological properties, including antioxidant, antimicrobial, and anticancer activities. This study evaluates the anti-diarrheal effect of phytol (PHY) along with its possible mechanism of action through in-vivo and in-silico models. The effect of PHY was investigated on castor oil-induced diarrhea in Swiss mice by using prazosin, propranolol, loperamide, and nifedipine as standards with or without PHY.PHY at 50 mg/kg (p.o.) and all other standards exhibit significant (p < 0.05) anti-diarrheal effect in mice. The effect was prominent in the loperamide and propranolol groups. PHY co-treated with prazosin and propranolol was found to increase in latent periods along with a significant reduction in diarrheal section during the observation period than other individual or combined groups. Furthermore, molecular docking studies also suggested that PHY showed better interactions with the α-and β-adrenergic receptors, especially with α-ADR1a and β-ADR1. In the former case, PHY showed interaction with hydroxyl group of Ser192 at a distance of 2.91Å, while in the latter it showed hydrogen bond interactions with Thr170 and Lys297 with a distance of 2.65 and 2.72Å, respectively. PHY exerted significant anti-diarrheal effect in Swiss mice, possibly through blocking α-and β-adrenergic receptors.

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Antidiarrheal effect of extract from the bark of Combretum leprosum in mice

Cited by 6 publications

References 34 publications

Physiological and biochemical responses of “mofumbo” seeds during storage

Physiological and biochemical responses of “mofumbo” seeds during storage

Modulatory Anti- Diarrheal Effects of Ascorbic Acid in Swiss Albino Mice

Anti-diarrheal activities of phytol along with its possible mechanism of action through in-vivo and in-silico models

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