Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives

Pinheiro, Luiz C. S.; Feitosa, Lívia M.; Silveira, Flávia F.; Boechat, Núbia

doi:10.1590/0001-3765201820170830

Cited by 64 publications

(26 citation statements)

References 60 publications

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“…The World Health Organization has recommended A. annua as an antimalarial drug. 27 Its most common ethnobotanical practice involves the use of whole plant decoction for the treatment of malaria, cough, and cold. Its dry leaf powder has been reported in the treatment of diarrhea.…”

Section: Traditional and Current Usesmentioning

confidence: 99%

Bioactive Compounds and Health Benefits ofArtemisiaSpecies

Nigam

Atanassova²,

Mishra

et al. 2019

Natural Product Communications

138

125

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Artemisia L. is a genus of small herbs and shrubs found in northern temperate regions. It belongs to the important family Asteraceae, one of the most numerous plant groupings, which comprises about 1000 genera and over 20000 species. Artemisia has a broad spectrum of bioactivity, owing to the presence of several active ingredients or secondary metabolites, which work through various modes of action. It has widespread pharmacological activities and has been used as traditional medicine since ancient times as an anthelmintic, antispasmodic, antirheumatic, and antibacterial agent and for the treatment of malaria, hepatitis, cancer, inflammation, and menstrual-related disorders. This review comprises the updated information about the ethnomedical uses and health benefits of various Artemisia spp. and general information about bioactive compounds and free radicals.

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Section: Traditional and Current Usesmentioning

confidence: 99%

Bioactive Compounds and Health Benefits ofArtemisiaSpecies

Nigam

Atanassova²,

Mishra

et al. 2019

Natural Product Communications

138

125

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“…Mepacrine (quinacrine) is another derivative of methylene blue used to treat malaria during World War II. 17 Chloroquine developed during World War II to treat malaria. Chloroquine is a drug of choice to treat malarial due to its efficacy, safety, and low cost.…”

Section: Antimalarial Drugsmentioning

confidence: 99%

“…Mepacrine (quinacrine) is another derivative of methylene blue used to treat malaria during World War II. 17 …”

Section: Antimalarial Drugsmentioning

confidence: 99%

<p>Recent Progress in the Development of New Antimalarial Drugs with Novel Targets</p>

Belete¹

2020

DDDT

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Malaria is a major global health problem that causes significant mortality and morbidity annually. The therapeutic options are scarce and massively challenged by the emergence of resistant parasite strains, which causes a major obstacle to malaria control. To prevent a potential public health emergency, there is an urgent need for new antimalarial drugs, with single-dose cures, broad therapeutic potential, and novel mechanism of action. Antimalarial drug development can follow several approaches ranging from modifications of existing agents to the design of novel agents that act against novel targets. Modern advancement in the biology of the parasite and the availability of the different genomic techniques provide a wide range of novel targets in the development of new therapy. Several promising targets for drug intervention have been revealed in recent years. Therefore, this review focuses on the progress made on the latest scientific and technological advances in the discovery and development of novel antimalarial agents. Among the most interesting antimalarial target proteins currently studied are proteases, protein kinases, Plasmodium sugar transporter inhibitor, aquaporin-3 inhibitor, choline transport inhibitor, dihydroorotate dehydrogenase inhibitor, isoprenoid biosynthesis inhibitor, farnesyltransferase inhibitor and enzymes are involved in lipid metabolism and DNA replication. This review summarizes the novel molecular targets and their inhibitors for antimalarial drug development approaches.

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“…Mefloquine interferes with the transport of hemoglobin and other substances from the erythrocytes to the food vacuoles of the malaria parasite. However, the drug has an effect on the asexual forms of the parasite in the blood (blood schizontocidal effect) [64].…”

Section: Antimalarial Activitymentioning

confidence: 99%

Schiff Bases as Important Class of Pharmacological Agents

Dzeikala¹,

Sykuła²

2018

JPP

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Therapeutics are compounds, which do not always exhibit healing powers. They sometimes prevent or control roles. Many compounds, well known or less are treated as the therapeutic agents. Among them, there is a specific group of molecules named commonly as Schiff bases, chemically imines. Schiff bases are aldehyde-or ketone-like compounds in which the carbonyl group is replaced by an imine -HN=СН-or azomethine -NHN=СН-group, they are an important class of compounds for new drug development. Schiff base modifications so far proved to be very effective with increased efficacy and reduced toxicity. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activity. The aim of this work was to present some interesting and promising examples of Schiff bases which exhibit biological activity.

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Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives

Cited by 64 publications

References 60 publications

Bioactive Compounds and Health Benefits ofArtemisiaSpecies

Bioactive Compounds and Health Benefits ofArtemisiaSpecies

<p>Recent Progress in the Development of New Antimalarial Drugs with Novel Targets</p>

Schiff Bases as Important Class of Pharmacological Agents

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