Influence of hesperidin and vitamin C on glycemic parameters, lipid profile, and DNA damage in rats treated with sucrose overload

Franke, Silvia Isabel Rech; Molz, Patrí­cia; Mai, Camila; Ellwanger, Joel Henrique; Zenkner, Fernanda Fleig; Horta, Jorge André; Prá, Daniel

doi:10.1590/0001-3765201820170751

Cited by 7 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The elevated serum LDL-c, triglyceride, and total cholesterol values here in hyperthyroidism group are consistent with those reported by many previous studies (1,41). Likewise, Franke et al (42) found that HDL-c level was significantly reduced in hyperthyroidism model rats.…”

Section: U N O H I S T O C He M I C a L E Ff E C T S O F H E S P E R ...supporting

confidence: 92%

See 1 more Smart Citation

Hormonal and inflammatory modulatory effects of hesperidin in hyperthyroidism-modeled rats

et al. 2023

View full text Add to dashboard Cite

The goal of the current study was to investigate the hormonal modulatory efficiency of hesperidin, through its regulatory potential of immunological, inflammatory, and/or antioxidant changes in on hyperthyroidism modeled adult female albino rats. Both normal and hyperthyroidism modeled rats (140-160g) were randomly divided into four groups (10 animals each) as follows: 1) healthy animals were daily ingested with saline for six weeks, and served as control group, 2) healthy animals were intraperitoneally injected with hesperidin (50 mg/kg/day) for a similar period, 3) hyperthyroidism-modeled animals without any treatment acted as positive control, and 4) hyperthyroidism-modeled animals were treated intraperitoneally with hesperidin for a similar period. The findings showed that hesperidin significantly modulated hyperthyroidism deteriorations, this was evidenced by a remarkable decline in serum T4, FT4, T3, FT3, TNF-α, IL1β-, IL4-, IL-6, and IL-10 levels, with a minor increase in TSH and significant raise in CD4+ level. Similarly, valuable improvement was observed in the oxidative status; serum SOD, GPx, CAT, and GSH levels were dramatically enhanced, associated with remarkable drop in MDA and NO levels. Also, hesperidin demonstrated nephro-hepatoprotective and anti-atherogenic potential, this was achieved from the notable reduction in ALAT and ASAT activities as well as urea, creatinine, cholesterol, and triglyceride close to the corresponding values of healthy group. These findings were supported by histological and immunohistochemical ones that showed a notable decrease in the expression of the calcitonin antibody. In conclusion, hesperidin possesses anti-hyperthyroidism, immunoinflammatory regulatory, and antioxidant activities that evidenced from the improvement of physio-architecture of the thyroid gland, reduction of inflammation and restoration of the impaired oxidative stress. This effect might be mechanized through immunological, inflammatory, apoptotic, and/or antioxidant modulatory pathways.

show abstract

Section: U N O H I S T O C He M I C a L E Ff E C T S O F H E S P E R ...supporting

confidence: 92%

“…Likewise, Franke et al. ( 42 ) found that HDL-c level was significantly reduced in hyperthyroidism model rats.…”

Section: Discussionmentioning

confidence: 93%

Hormonal and inflammatory modulatory effects of hesperidin in hyperthyroidism-modeled rats

et al. 2023

View full text Add to dashboard Cite

show abstract

“…58 In addition, hesperidin stimulates glycogenolysis and glycolysis in isolated perfused rat liver 57 and reduces glucose levels induced in porcine streptozotocininduced diabetic and diabetic rat models. 82 The postprandial glycemic response of orange juice can be adjusted by partially inhibiting the intestinal glucose transporter according to the concentration of sugar and hesperidin, 83 indicating that hesperidin can be used to prevent postprandial hyperglycemia. 40 PPAR-c is a nuclear protein transcription factor that regulates lipid and glucose metabolism, and hesperidin maintains glucose metabolism by regulating PPAR-c activation and inhibiting fat accumulation.…”

Section: The Effect Of Hesperidin On Glucose Metabolismmentioning

confidence: 99%

<p>Hesperidin: A Therapeutic Agent For Obesity</p>

Xiong¹,

Wang²,

Ran³

et al. 2019

DDDT

117

View full text Add to dashboard Cite

Obesity is a chronic metabolic disease caused by multiple factors and is considered to be a risk factor for type 2 diabetes, cardiovascular disease, hypertension, stroke and various cancers. Hesperidin, a flavanone glycoside, is a natural phenolic compound with a wide range of biological effects. Mounting evidence has demonstrated that hesperidin possesses inhibitory effect against obesity diseases. Our review discusses mechanisms of hesperidin in the treatment of obesity. Hesperidin regulates lipid metabolism and glucose metabolism by mediating AMPK and PPAR signaling pathways, directly regulates antioxidant index and anti-apoptosis, and indirectly mediates NF-κB signaling pathway to regulate inflammation to play a role in the treatment of obesity. In addition, hesperidin-enriched dietary supplements can significantly improve symptoms such as postprandial hyperglycemia and hyperlipidemia. Further clinical trials are also required for confirming lipid-lowering efficacy of this natural flavonoid and evaluating its safety profile.

show abstract

“…Also, in the liver of rats, hesperidin stimulates glycogenolysis and glycolysis (do Nascimento et al, 2018 ). Moreover, the hypoglycemic effects of hesperidin have been shown in rat models of diabetes (Franke et al, 2018 ). Several studies have demonstrated that hesperidin might potentially be used to regulate postprandial blood glucose by reducing the intestinal glucose transporter (Kerimi et al, 2019 ; Shen et al, 2012 ).…”

Section: Hesperidin and Glucose Metabolismmentioning

confidence: 99%

A narrative review on the role of hesperidin on metabolic parameters, liver enzymes, and inflammatory markers in nonalcoholic fatty liver disease

Morshedzadeh,

Ramezani Ahmadi,

Behrouz

et al. 2023

Food Science & Nutrition

View full text Add to dashboard Cite

Insulin resistance, oxidative stress, hyperlipidemia, and inflammation play main roles in the development of nonalcoholic fatty liver disease (NAFLD). Some studies have reported that hesperidin can reduce hyperglycemia and hyperlipidemia by inhibiting inflammatory pathways. In the current study, our purpose was to evaluate whether it can influence the primary parameters in NAFLD and improve the treatment effectiveness for future trials. Various studies have found that hesperidin involves multiple signaling pathways such as cell proliferation, lipid and glucose metabolism, insulin resistance, oxidative stress, and inflammation, which can potentially affect NAFLD development and prognosis. Recent findings indicate that hesperidin also regulates key enzymes and may affect the severity of liver fibrosis. Hesperidin inhibits reactive oxygen species production that potentially interferes with the activation of transcription factors like nuclear factor‐κB. Appropriate adherence to hesperidin may be a promising approach to modulate inflammatory pathways, metabolic indices, hepatic steatosis, and liver injury.

show abstract

Influence of hesperidin and vitamin C on glycemic parameters, lipid profile, and DNA damage in rats treated with sucrose overload

Cited by 7 publications

References 36 publications

Hormonal and inflammatory modulatory effects of hesperidin in hyperthyroidism-modeled rats

Hormonal and inflammatory modulatory effects of hesperidin in hyperthyroidism-modeled rats

<p>Hesperidin: A Therapeutic Agent For Obesity</p>

A narrative review on the role of hesperidin on metabolic parameters, liver enzymes, and inflammatory markers in nonalcoholic fatty liver disease

Contact Info

Product

Resources

About