The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement: a systematic review

Abstract

The present study aimed to perform a systematic literature review to determine if there is a non-steroidal anti-inflammatory drug (NSAID) that interferes less within tooth movement. This research was performed according to the PRISMA statement. Articles were searched in eight electronic databases (PubMed, Scopus, Embase, Web of Science, LILACS, SciELO, Google Scholar, and Open Grey). Only experimental studies on male Wistar rats were selected, which included experiments related to the influence of NSAIDs on orthodontic movement. Studies in animals with pathological conditions, literature review articles, letters to the editor and/or editorials, case reports, abstracts, books, and book chapters were excluded. Each of the steps of this systematic literature review was performed by two examiners independently. Results: the total sample consisted of 505 articles, from which 6 studies were eligible after a qualitative analysis. From the drugs assessed, paracetamol was unanimous for not interfering within orthodontic movement when compared to the control group. However, drugs such as aspirin, ibuprofen, sodium diclofenac, and selective cyclooxygenase-2 inhibitors caused a reduction in tooth movement when compared to the control group. Conclusion: paracetamol could be considered the drug of choice for pain relief because it interferes less within tooth movement.

Do analgesics used for the pain experienced after orthodontic procedures affect tooth movement rate? A systematic review based on animal studies

“…In the present systematic review, we followed well‐established guidelines and conducted an exhaustive search up to June 2019 that was comprehensive and included every potentially relevant study, contrary to existing investigations focusing on specific medication categories and animal species . Moreover, the retrieved contemporary data add on the information provided in earlier systematic reviews, which did not focus specifically on the short‐term systemic administration of analgesics, that is consistent with the usual clinical practice in case of pain experienced due to orthodontic procedures .…”

Effect of a 5% naproxen patch on reducing pain caused by separators prior to fixed orthodontic treatment

“…It should also be used with caution in patients suffering from kidney or liver diseases [ 16 ]. Furthermore, it has been shown that tooth movement could be impaired if high concentrations of NSAIDS are used [ 30 ]; however, the patches were used only during the separator placement stage of treatment (3 days) and not for the whole duration of fixed orthodontic treatment, and thus it could not have interfered with tooth movement. It is also important to point out that the amount of naproxen in the patch was 5 mg, which was rather low (overall = 9 × 5 = 45 mg for all patches), and thus it could not have had any significant systemic effects.…”

Skausmas Ir Diskomfortas Ortodontinio Gydymo Breketų Sistema Metu

“…Dantų judėjimą sukelia nuolat veikiančios mechaninės jėgos, kurias sukuria ortodontiniai prietaisai. Šio proceso metu, kaip minėta anksčiau, vyksta uždegiminiai pokyčiai periodonto audiniuose, kraujyje padaugėja uždegiminių mediatorių, sukeliančių skausmą [17], todėl skausmo kontrolė ortodontinio gydymo metu (ypač gydymo pradžioje) yra labai svarbi.…”

“…Šie preparatai veikia kaip prostaglandinų inhibitoriai, todėl mažina sisteminį uždegiminį procesą. Prostaglandinai dalyvauja kaulo rezorbcijoje, todėl jų slopinimas gali neigiamai paveikti dantų judėjimo greitį ar sukelti dantų šaknų rezorbciją [14,17]. Jei pacientas sveikas, analgetikai pašalinami iš organizmo dar prieš prasidedant dantų judėjimui, todėl gydymo pradžioje NVNU pavartojus trumpą laiką ir mažomis dozėmis, dantų judėjimo greitis nebus paveikiamas [4,18].…”