Effects of electroacupuncture on stress and anxiety-related responses in rats

Bassetto, Ricardo Morad; Wscieklica, Tatiana; Pouza, Kathlein Cristiny Peres; Ortolani, Daniela; Viana, Milena de Barros; Céspedes, Isabel Cristina; Spadari, Regina Célia

doi:10.1590/0001-3765201720160531

Cited by 6 publications

(3 citation statements)

References 49 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…About 19% of patients with temporal lobe epilepsy had an anxiety disorder, suggesting the linkage of temporal lobe dysfunction with anxiety. 15 The parahippocampal gyrus, located between the hippocampus and temporal lobe, functions in spatial memory and navigation. Lines of evidence have reported that the activity of the parahippocampal gyrus is involved in the regulation of sensory memory.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acupuncture at Neiguan in Neural Activity of Related Brain Regions: A Resting-State fMRI Study in Anxiety

Li¹,

Wang²,

Li³

et al. 2022

NDT

View full text Add to dashboard Cite

Background Acupuncture of PC6 points has the effects of calming, tranquilizing, regulating qi, and relieving pain and has been clinically found to alleviate anxiety disorders. To explore the mechanism of improvement at the Neiguan point acupuncture in anxiety patients, we used fMRI to observe the changes in brain function in patients with immediate anxiety before and after acupuncture at the Neiguan point. Subjects and Methods The experiment followed the principle of randomized, single-blind design. Twenty-four anxiety volunteers (14 males and 10 females, 20–35 years old) were divided randomly into two groups: a group of acupuncture at Neiguan and a group of acupuncture at non-acupoint. Functional magnetic resonance imaging (fMRI) was applied to measure brain activity pre- and post-acupuncture. The amplitude of low-frequency fluctuations (ALFF) and seed-based functional connectivity (FC) was used to analyze the activity and network of brain regions. Statistical analysis was done using SPSS 21.0 and REST 1.8 software. Results ALFF results revealed that post-acupuncture at Neiguan increased the activity of the left parahippocampal gyrus, fusiform gyrus, and right superior temporal gyrus and decreased the activity of the right middle frontal gyrus, right precuneus, and cuneus. Post-acupuncture at non-acupoint led to a significant ALFF increase in the thalamus and middle frontal gyrus. The ALFF in the left middle frontal gyrus was decreased. Functional connectivity in several anterior default mode network (DMN) regions and vermis cerebelli at left parahippocampal/fusiform gyri was increased, and connectivity in bilateral superior temporal gyri was decreased. FC with posterior DMN regions decreased at the right middle frontal gyrus, right precuneus, and cuneus. Conclusion Our study elucidates that acupuncture at Neiguan modulates anxiety by activating or deactivating these brain anxiety-related regions and provides potential explanations for the application of PC6 acupuncture in mental diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Acupuncture at Neiguan in Neural Activity of Related Brain Regions: A Resting-State fMRI Study in Anxiety

Li¹,

Wang²,

Li³

et al. 2022

NDT

View full text Add to dashboard Cite

show abstract

“…In addition, a randomized controlled trial showed that stimulation of Yintang acupoint resulted in a significant reduction of anxiety in patients planned for neurosurgical intervention [21]. The mechanism of acupuncture in causing decreased anxiety based on magnetic resonance imaging is related to reduced activity of the CNS components like the limbic system, amygdala, and hypothalamus [46]. Auricular acupuncture has been found to be effective in treating chronic anxiety disorder, and a similar anxiolytic effect was reported in studies related to dental anxiety [47,48].…”

Section: Gaurav Kumar and Sanjay Tewarimentioning

confidence: 99%

Acupuncture for Management of Endodontic Emergencies: a Review

Kumar

Tewari²

2023

J Acupunct Meridian Stud

View full text Add to dashboard Cite

Root canal treatment (RCT) employed for painful endodontic conditions like apical periodontitis and irreversible pulpitis is associated with a high incidence of postoperative pain. Pharmacological management for this purpose is effective, but not entirely free from side effects and in some cases may fail to provide adequate relief. Furthermore, concerns have been raised regarding the transmission of coronavirus disease-2019 (COVID-19) as a result of the aerosols generated and prolonged chair side time required for RCT. Acupuncture is a traditional Chinese therapy commonly employed as an alternative for the treatment of pain. And what's more, the use of acupuncture has been recently reported as treatment for the management of endodontic pain as well as on the anesthetic success in patients with irreversible pulpitis. This review aims to evaluate the current evidence for acupuncture in endodontics and its potential role in emergency pain relief and management for patients. To combat this, a thorough search for literature within the field was performed in five electronic databases. Retrieved studies were screened according to the pre-defined eligibility criteria. After both an electronic and manual search, five studies were selected for review. These studies reported the beneficial effects of acupuncture in reducing the failure of nerve block in patients with irreversible pulpitis and in controlling both intraoperative and postoperative pain following RCT. In addition, it was also reported to reduce anxiety surrounding the dental procedure and minimized the intake of analgesics after the endodontic procedure, which can result in some unwanted side effects. However, more in depth clinical research is required before any recommendation regarding the application of acupuncture in endodontic patients can be made.

show abstract

“…As a form of acupuncture, electroacupuncture (EA) reinforces the function of acupuncture by continuous stimulation of acupoints with a small electric current. Accumulating evidence indicates that EA could attenuate the stress response [31][32][33] and regulate the HPA axis [34,35] and DA in the brain [36].…”

Section: Introductionmentioning

confidence: 99%

Effects of Electroacupuncture on Sleep via the Dopamine System of the HPA Axis in Rats after Cage Change

Xie

Wang

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Insomnia is often related to stressful events. The hypothalamus-pituitary-adrenal (HPA) axis is related to stress, and dopamine (DA) and DA receptors are involved in the regulation of HPA axis. Electroacupuncture (EA) can improve sleep in individuals with insomnia, but the mechanism is unclear. We demonstrated that EA can improve sleep in rats after cage change through DA and the DA receptors in the HPA axis. Methods. A rat model of insomnia was established by cage change to a dirty cage. The rats in treatment groups were intervened by EA and D1R (or D2R) antagonists. Electroencephalography (EEG) and electromyogram (EMG) were recorded to compare the changes in sleep. The DA, corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (CORT) levels in the plasma and hypothalamus were measured by ELISAs, and the D1R and D2R levels were measured by RT-PCR and immunohistochemistry. Results. The dirty group showed a significant increase in the amount of wakefulness and decrease in the amount of NREM sleep, with decreased numbers of long NREM sleep bouts and REM sleep bouts and increased mean duration of wakefulness during the light period. EA and D1R (or D2R) antagonists intervention could improve sleep disturbance by decreasing wakefulness in the light period after cage change, EA and D1R (or D2R) antagonists could increase the hypothalamus DA, CRH, ACTH, CORT level, and the D1R and D2R mRNA levels in the HPA axis, and the effect of EA plus D1R (or D2R) antagonist was not superior to that of EA or D1R (or D2R) antagonists alone. Conclusions. EA can improve the sleep of rats after cage change, and the mechanism may be related to the regulation of DA and D1R or D2R in the HPA axis.

show abstract

Effects of electroacupuncture on stress and anxiety-related responses in rats

Cited by 6 publications

References 49 publications

Effects of Acupuncture at Neiguan in Neural Activity of Related Brain Regions: A Resting-State fMRI Study in Anxiety

Effects of Acupuncture at Neiguan in Neural Activity of Related Brain Regions: A Resting-State fMRI Study in Anxiety

Acupuncture for Management of Endodontic Emergencies: a Review

Effects of Electroacupuncture on Sleep via the Dopamine System of the HPA Axis in Rats after Cage Change

Contact Info

Product

Resources

About