Effects of Acupuncture at Neiguan in Neural Activity of Related Brain Regions: A Resting-State fMRI Study in Anxiety

Li, Chunlin; Wang, Yuangeng; Li, Baopeng; Su, Shanshan

doi:10.2147/ndt.s368227

Cited by 8 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[16] In our previous study, acupuncture at the Neiguan point in patients with anxiety disorders was able to positively activate the left parahippocampal gyrus, cingulate gyrus, and right superior temporal gyrus, and negatively activate the right middle frontal gyrus, right precuneus, and cuneus regions. [17] The frontal lobe is the higher center that controls human behavior, thoughts, and emotions. The ACC and the medial prefrontal cortex (mPFC) comprise the medial wall of the frontal lobe.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of acupuncture at the Yuji point on resting-state brain function in anxiety

Wang

2023

Medicine

Self Cite

View full text Add to dashboard Cite

Background: The COVID-19 epidemic has placed a lot of mental burdens on school students, causing anxiety. Clinically, it has been found that the Yuji point (LU10) can relieve anxiety by regulating Qi. Methods: Thirty-six volunteers with anxiety disorders were divided into 3 groups, all of whom underwent 2 MRI examinations. The Yuji and nonacupoint groups received acupuncture between functional magnetic resonance imagings. We used the amplitude of low-frequency fluctuation to analyze regional brain activity, and seed-based functional connectivity (FC) to analyze changes in brain networks. Results: After acupuncture, the LU10 was able to activate the frontal lobe, medial frontal gyrus, anterior cingulate gyrus, temporal lobe, hippocampus, etc in the left brain compared to the control group. The frontal lobe, medial frontal gyrus, cingulate gyrus, and anterior cingulate gyrus in the left brain were activated compared to those in the nonacupoint group. Compared with the control group, LU10 showed increased FC in the right parietal lobe, right precuneus, left temporal lobe, left superior temporal gyrus, and with cingulate gyrus. FC was enhanced among the hippocampus with the left temporal lobe and the superior temporal gyrus and reduced in the right lingual gyrus and right occipital lobe. Conclusion: Acupuncture at LU10s can regulate anxiety by upregulating or downregulating the relevant brain regions and networks. LU10s can be used to treat not only lung disorders but also related mental disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of acupuncture at the Yuji point on resting-state brain function in anxiety

Wang

2023

Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…The increased activities of the thalamic cortex could also cause the increased activities of the insula and pain constant perception [ 39 ]. The thalamus is closely connected with the amygdala, which plays a vital role in producing fear, anxiety, and other emotional responses, such as guilt [ 40 ]. The augmented mALFF value of the right amygdala was also detected, which disclosed the potential functional relationship between the thalamus and the right amygdala in the anxiety disorder of CP/CPPS.…”

Section: Discussionmentioning

confidence: 99%

The ALFF Alterations of Spontaneous Pelvic Pain in the Patients of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Evaluated by fMRI

Xia

et al. 2022

Brain Sciences

View full text Add to dashboard Cite

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a challenging entity with complicated symptoms for treatment in the male crowd. Accumulating evidence revealed the dysfunction in the central system should be a critical factor for the pathogenesis and development in the CP/CPPS. Therefore, we recruited 20 patients of CP/CPPS and 20 healthy male volunteers, aged 20 to 50 years. Through resting-state functional magnetic resonance imaging (fMRI), we analyzed the mean amplitude of low-frequency fluctuations (mALFF) and the mean fractional amplitude of low-frequency fluctuations (mfALFF) to reflect the spontaneous abnormal activated regions in the brains of CP/CPPS patients. Compared to the healthy controls, the group with CP/CPPS had significantly increased mALFF values in the thalamus and augmented fALFF values in the inferior parietal lobule and cingulate gyrus. Significant positive correlations were observed in the extracted mALFF values in the midbrain periaqueductal gray matter (PAG) and the pain intensity (r = 0.2712, p = 0.0019), mALFF values in the thalamus and the scores of Hospital Anxiety and Depression Scale (HADS) anxiety subscale (r = 0.08477, p = 0.0461), and mfALFF values in the superior frontal gyrus (SFG) and the scores of the HADS anxiety subscale (r = 0.07102, p = 0.0282). Therefore, we delineated the clinical alterations in patients of CP/CPPS that might be attributed to the functional abnormality of the thalamus, inferior parietal lobule, and cingulate gyrus. Among these regions, the PAG, thalamus, and SFG may further play an important role in the pathogenesis, with their regulating effect on pain or emotion.

show abstract

“…In TCM theory, the Neiguan (PC6) acupoint belongs to the sixth acupoint of the pericardium meridian (PC). Acupuncture on the PC6 point is used to calm the mind, soothe the nerves, regulate qi and relieve pain [ 33 ]. In addition, acupressure at Neiguan (PC6) affects nausea, vomiting and comfort level in the postoperative period [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

A System Based on Photoplethysmography and Photobiomodulation for Autonomic Nervous System Measurement and Adjustment

Shan

Fang

2023

Life

View full text Add to dashboard Cite

(1) Background: The imbalance of the autonomic nervous system (ANS) is common worldwide. Many people have high tension when the sympathetic nervous system is hyperactive or low attention when the parasympathetic nervous system is hyperactive. To improve autonomic imbalance, a feasible and integrated system was proposed to measure and affect the ANS status. (2) Methods: The proposed system consists of a signal-processing module, an LED stimulation module, a photoplethysmography (PPG) sensor and an LCD display. The heart rate variability (HRV) and ANS status can be analyzed from PPG data. To confirm HRV analysis from PPG data, an electrocardiogram (ECG) device was also used to measure HRV. Additionally, photobiomodulation (PBM) was used to affect the ANS status, and two acupuncture points (Neiguan (PC6) and Shenmen (HT7)) were stimulated with different frequencies (10 Hz and 40 Hz) of PBM. (3) Results: Two subjects were tested with the developed system. HRV metrics were discussed in the time domain and frequency domain. HRV metrics have a similar change trend on PPG and ECG signals. In addition, the SDNN was increased, and the parasympathetic nervous system (PNS: HF (%)) was enhanced with a 10 Hz pulse rate stimulation at the Neiguan acupoint (PC6). Furthermore, the SDNN was increased, and the sympathetic nervous system (SNS: LF (%)) was enhanced with a 40 Hz pulse rate stimulation at the Shenmen (HT7) acupoint. (4) Conclusion: A prototype to measure and affect the ANS was proposed, and the functions were feasible. The test results show that stimulating the Neiguan (PC6) acupoint can inhibit the SNS. In contrast, stimulating the Shenmen (HT7) acupoint can activate the SNS. However, more experiments must be conducted to confirm the effect by choosing different pulse rates, dosages and acupoints.

show abstract

Effects of Acupuncture at Neiguan in Neural Activity of Related Brain Regions: A Resting-State fMRI Study in Anxiety

Cited by 8 publications

References 38 publications

The effect of acupuncture at the Yuji point on resting-state brain function in anxiety

The effect of acupuncture at the Yuji point on resting-state brain function in anxiety

The ALFF Alterations of Spontaneous Pelvic Pain in the Patients of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Evaluated by fMRI

A System Based on Photoplethysmography and Photobiomodulation for Autonomic Nervous System Measurement and Adjustment

Contact Info

Product

Resources

About