Indicators related to the rational use of medicines and its associated factors

Lima, Marina Guimarães; Álvares, Juliana; Guerra, Augusto Afonso; Costa, Ediná Alves; Guibu, Ione Aquemi; Soeiro, Orlando Mário; Leite, Silvana Nair; Karnikowski, Margô Gomes de Oliveira; Costa, Karen Sarmento; Acúrcio, Francisco de Assis

doi:10.11606/s1518-8787.2017051007137

Cited by 38 publications

(37 citation statements)

References 16 publications

(25 reference statements)

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“…The study results are in agreement with previous studies which also showed that these regions have better indicators. 27,28,29 Differences in the quantities of opioid analgesics dispensed may reflect the existence of differences in access to these drugs between states. Most Brazilian states have relatively low dispensing rates of opioid analgesics for dental care purposes.…”

Section: Discussionmentioning

confidence: 99%

A national study on the use of opioid analgesics in dentistry

Lino

Sohn²,

Singhal

et al. 2019

Braz. oral res.

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The aim of this study was to assess the frequency of opioid analgesics prescribed by Brazilian dentists, potential regional differences and their association with socioeconomic and health-related factors. Data for all opioid prescriptions by dentists was obtained from the 2012 database of the National Controlled Substances Management System, regulated by the Brazilian Health Surveillance Agency. The number of defined daily doses (DDD) and DDDs per 1,000 inhabitants per day for each Brazilian state were calculated as the primary outcomes. DDDs were compared by regions and Brazilian states. Spearman's rho correlation coefficient was used to determine the influence of the states' characteristics, such as the Human Development Index; poverty; education; number of dentists per 100,000 inhabitants; visit to the dentist; dental care plan; good or very good oral health; number of pharmaceutical establishments per 100,000/inhabitants; and ability to get all prescribed medications. Data analysis was performed using IBM SPSS Statistics 25.0. A total of 141,161 prescriptions for opioids analgesics by 36,929 dentists were recorded, corresponding to 658,855 doses of opioids dispensed in 2012. The most commonly dispensed opioids were codeine associated with paracetamol (83.2%; n = 117,493). The national DDDs per 1,000 inhabitants per day was 0.0093 (range: 0.0002-0.0216). DDD per 1,000 inhabitants per day was positively associated to visits to dentists (rs = 0.630; P < 0.001) and inversely associated to poverty (rs =-0.624; p = 0.001). There are significant differences in opioid prescriptions in dentistry among the Brazilian states. These differences may be associated with non-clinical factors.

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Section: Discussionmentioning

confidence: 99%

A national study on the use of opioid analgesics in dentistry

Lino

Sohn²,

Singhal

et al. 2019

Braz. oral res.

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“…Antimicrobial resistance is an old and huge concern for public health systems, having grown rapidly in recent times, spreading the preoccupation to economics [92,[95][96][97]. The use of gold, silver, aluminum, and iron oxide as antimicrobials was previously proven [29,[98][99][100][101][102].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…The use of IOMNPs to oppose microorganism infection is quite relevant when thinking about this resistance. However, it may not overcome all kinds of bacterial resistance [97,[104][105][106][107][108].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

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“…Desta maneira e com base nos resultados demonstrados no presente trabalho, fica evidente a necessidade de aprimoramento em relação ao uso racional de medicamentos envolvendo a classe dos AINEs, ressaltando que o uso racional é definido como, a utilização do medicamento apropriado para a condição clínica, em doses que atendam às necessidades de saúde individuais, por um período adequado e ao menor custo (12) .…”

Section: Métodosunclassified