Are Endocan Plasma Levels Altered in Preeclampsia?

Lopes, Ana Cristina dos Santos; Martins, Suellen Rodrigues; Dusse, Luci Maria Sant’Ana; Pinheiro, Melina de Barros; Alpoim, Patrícia Nessralla

doi:10.1055/s-0041-1728661

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Furthermore, endocan was highly expressed in fetal and maternal endothelial cells in the case of hypertension during pregnancy, and its expression was related to fetal low birth weight and premature delivery [73]. On the contrary, some other studies failed to demonstrate significant differences in serum endocan among non-pregnant women, normal pregnant women, and women with preeclampsia, indicating that endocan may not be involved in the pathogenesis of preeclampsia [74][75][76]. Taken all together, it is feasible to conclude that attenuated systemic vasodilation is related to increased oxidative stress due to high dietary salt intake even in pregnant women.…”

Section: Discussionmentioning

confidence: 99%

High dietary salt intake attenuates nitric oxide mediated endothelium-dependent vasodilation and increases oxidative stress in pregnancy

Vulin,

Muller,

Drenjančević

et al. 2024

Journal of Hypertension

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Objective: This study aimed to investigate the impact of dietary salt intake during normal pregnancy on maternal microvascular and macrovascular endothelium-dependent reactivity and oxidative stress level. Materials and methods: In this cross-sectional study, based on their 24-h urinary sodium excretion, pregnant women (37–40 weeks of gestation) were divided into three groups: normal salt (<5.75 g/day, N = 12), high salt (5.75–10.25 g/day, N = 36), and very high salt (VHS;>10.25 g/day, N = 17). Forearm skin microvascular reactivity in response to vascular occlusion, local heating (LTH) and iontophoresis of acetylcholine (AChID), as well as brachial artery flow mediated dilation (FMD) were measured. Serum nitric oxide, endocan, 8-iso-prostaglandin F2α (8-iso-PGF2α), thiobarbituric acid reactive substances (TBARS), and ferric-reducing ability of plasma assay were measured as biomarkers of endothelial function/activation and oxidative stress. Results: Brachial artery FMD, microvascular AChID, and LTH were significantly decreased in VHS compared with NS group, while LTH was also decreased in normal salt compared with high salt group. Nitric oxide was significantly decreased in both high salt and VHS groups compared with normal salt. Endocan, 8-iso-PGF2α, and TBARS were significantly increased in VHS compared with the normal salt group. Conclusion: High dietary salt intake is associated with decreased nitric oxide mediated endothelium-dependent vasodilation in peripheral microcirculation and macrocirculation of healthy pregnant women due to increased oxidative stress.

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Section: Discussionmentioning

confidence: 99%

High dietary salt intake attenuates nitric oxide mediated endothelium-dependent vasodilation and increases oxidative stress in pregnancy

Vulin,

Muller,

Drenjančević

et al. 2024

Journal of Hypertension

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May endocan be a new biomarker in the diagnosis of endometriosis?

Senocak

Yapça

Yılmaz

et al. 2022

Journal of Gynecology Obstetrics and Human Reproduction

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The relationship between pregnancies complicated with fetal growth restriction and umbilical cord blood endocan concentrations

Özgökçe

Meral

2022

Turkish Journal of Biochemistry

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Objectives The main etiological factor in intrauterine growth restriction (IUGR) is the impairment of the fetoplacental unit. Due to the placental endothelial disintegrity and vascular permeability disruptions, endocan has been an interesting molecule to search for associations with IUGR. The aim of this study was to investigate the umbilical cord blood endocan concentrations in IUGR pregnancies. Materials and methods This cross-sectional case-control study was conducted on 50 IUGR-complicated (patients) and 50 control pregnancies. The demographics and clinical findings were recruited from records. The umbilical cord blood was studied for endocan concentrations. Results The patient group compared to controls had significantly more previous IUGR history, lower maternal weight gain, an earlier gestational week at delivery, and more cesarean sections (p<0.001). The umbilical cord endocan concentrations were significantly higher in patients than in controls (p<0.001). Oligohydramnios (n=38) was significantly higher in the patients and had a significant relationship with high endocan concentrations (p<0.001). Moderate and mild positive correlations were found among endocan concentration and biparietal diameter/head circumference and femur length values, respectively, while a moderate negative correlation was observed in abdominal circumference values (p<0.001). Conclusions A significant increase in the umbilical cord blood endocan concentrations was found in IUGR pregnancies.

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Are Endocan Plasma Levels Altered in Preeclampsia?

Cited by 3 publications

References 26 publications

High dietary salt intake attenuates nitric oxide mediated endothelium-dependent vasodilation and increases oxidative stress in pregnancy

High dietary salt intake attenuates nitric oxide mediated endothelium-dependent vasodilation and increases oxidative stress in pregnancy

May endocan be a new biomarker in the diagnosis of endometriosis?

The relationship between pregnancies complicated with fetal growth restriction and umbilical cord blood endocan concentrations

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