Coronavirus 2019, Thrombocytopenia and HELLP Syndrome: Association or Coincidence?

Braga, Luiz Felipe Bagnatori; Sass, Nelson

doi:10.1055/s-0040-1718437

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…Diagnosing and managing such tropical infections in pregnancy during the COVID-19 era is another challenge that was faced during the management of our cases. COVID-19 has also been reported in association with HELLP syndrome with similar presenting features such as our cases [23,24]. COVID-19 and dengue co-infection have also been reported before leading to adverse outcomes due to antibody-dependent enhancement, which also led to hepatic failure [25].…”

Section: Discussionsupporting

confidence: 73%

Tropical Infections Induced Fulminant Hepatitis in Peripartum Managed Successfully: Tales of Fate

Tayade¹,

Madaan²,

Kumar³

et al. 2022

Cureus

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Tropical diseases such as malaria, dengue, intestinal helminths, schistosomiasis, leishmaniasis, and filariasis have an essential influence on the reproductive health of patients.Various cases of pregnancy loss in unexplained circumstances are a result of underdiagnosed tropical diseases. Term pregnancy complicated by tropical diseases is a challenge for the treating clinicians as these infections tend to mimic HELLP (Hemolysis, Elevated Liver enzymes, and Low Platelets) syndrome and increase the chances of perinatal complications and maternal mortality. Except for tropical diseases, ever since the conception of the COVID-19 pandemic, the differentials for fever pregnancy have become extensive, and the treating clinicians need to solve the puzzle of the etiology behind these symptoms that are non-specific and might be due to both COVID-19 and tropical Infections. Prophylactic treatment for malaria is pivotal in pregnancy as immunity is decreased during pregnancy, making the patient susceptible to developing malaria-related complications. Dengue is one of the most common mosquito-borne infections found around the globe. Complications of dengue during pregnancy include pregnancy loss as well as vertical transmission of infection to the fetus. Leptospirosis, even though rare, has a wide range of complications in pregnancy ranging from fetal loss to congenital infection and oligohydramnios, thereby requiring close monitoring and prompt management during pregnancy.We report a case series of three cases where patients presented during the period of pregnancy with fulminant hepatic failure, which turned out to be a consequence of tropical diseases. All the cases were treated successfully and discharged in stable condition.

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Section: Discussionsupporting

confidence: 73%

Tropical Infections Induced Fulminant Hepatitis in Peripartum Managed Successfully: Tales of Fate

Tayade¹,

Madaan²,

Kumar³

et al. 2022

Cureus

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“…Of the articles eligible (n ¼ 86) for full text reading, 70 were excluded for the following reasons: HIV infection (n ¼ 1), duplicate (n ¼ 3), study design (n ¼ 33), language (n ¼ 3) and lack of information/approach regarding pathophysiology and interaction (n ¼ 30). Finally,16 studies [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] were effectively included in this review (►Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

COVID-19 and Preeclampsia: A Systematic Review of Pathophysiological Interactions

Nascimento

Cunha

Netto

et al. 2023

Rev Bras Ginecol Obstet

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Objective: To review the literature and synthesize evidence on pathophysiological interactions attributed to the simultaneous occurrence of COVID-19 and preeclampsia. Methods: A systematic review was conducted from November (2021) to January (2022) to retrieve observational studies published on the PubMed, LILACS, SciELO Brazil and Google Scholar databases. The search was based on the descriptors [(eclampsia OR preeclampsia) AND (COVID-19)]. Quantitative studies that pointed to pathophysiological interactions were included. Literature reviews, studies with HIV participants, or with clinical approach only were excluded. The selection of studies was standardized and the evaluation was performed by pairs of researchers. Results: In this review, 155 publications were retrieved; 16 met the inclusion criteria. In summary, the physiological expression of angiotensin-converting enzyme-2 (ACE-2) receptors is physiologically increased in pregnant women, especially at the placental site. Studies suggest that the coronavirus binds to ACE-2 to enter the human cell, causing deregulation of the renin-angiotensin-aldosterone system and in the ratio between angiotensin-II and angiotensin-1-7, inducing manifestations suggestive of preeclampsia. Furthermore, the cytokine storm leads to endothelial dysfunction, vasculopathy and thrombus formation, also present in preeclampsia. Conclusion: The studies retrieved in this review suggest that there is a possible overlap of pathophysiological interactions between COVID-19 and preeclampsia, which mainly involve ACE-2 and endothelial dysfunction. Given that preeclampsia courses with progressive clinical and laboratory alterations, a highly quality prenatal care may be able to detect specific clinical and laboratory parameters to differentiate a true preeclampsia superimposed by covid-19, as well as cases with hypertensive manifestations resulting from viral infection.

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“…Nearly forty percent of patients have neurological manifestations (12). Most of these effects are seizures, delirium, and unconsciousness (45)(46)(47). A British study analyzed 153 patients with clinical syndromes related to COVID-19 pneumonia.…”

Section: Neurological Complicationmentioning

confidence: 99%

Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era

et al. 2021

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COVID-19 is widespread worldwide and seriously affects the daily life and health of humans. Countries around the world are taking necessary measures to curb the spread. However, COVID-19 patients often have at least one organ complication and sequelae in addition to respiratory symptoms. Controlling the epidemic is only a phased victory, and the complication and sequelae of COVID-19 will need more attention in the post-epidemic era. We collected general information from over 1000 articles published in 2020 after the COVID-19 outbreak and systematically analyzed the complication and sequelae associated with eight major systems in COVID-19 patients caused by ACE2 intervention in the RAS regulatory axis. The autoimmune response induced by 2019-nCoV attacks and damages the normal tissues and organs of the body. Our research will help medical workers worldwide address COVID-19 complication and sequelae.

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Coronavirus 2019, Thrombocytopenia and HELLP Syndrome: Association or Coincidence?

Cited by 7 publications

References 3 publications

Tropical Infections Induced Fulminant Hepatitis in Peripartum Managed Successfully: Tales of Fate

Tropical Infections Induced Fulminant Hepatitis in Peripartum Managed Successfully: Tales of Fate

COVID-19 and Preeclampsia: A Systematic Review of Pathophysiological Interactions

Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era

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