Effect of Vitamin D Injection in Recurrent Benign Paroxysmal Positional Vertigo with Vitamin D Deficiency

Rhim, Gu Il

doi:10.1055/s-0039-3402431

Cited by 6 publications

(7 citation statements)

References 26 publications

(45 reference statements)

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“…Our findings correlate with previous studies from countries around the world, where the potential influence of cold seasons, vitamin D deficiencies, female gender and age on the occurrence BPPV has been shown [ 3 , 13 , 14 , 18 , 21 , 24 , 25 , 27 , 32 , 38 ]. In the assumption that otoconia and bones share a similar mineralization metabolism, of which vitamin D is an integral part, risk factors for reduced bone mineral density have also been linked to BPPV [ 16 , 44 – 46 ].…”

Section: Discussionsupporting

confidence: 92%

Seasonality of benign paroxysmal positional vertigo

Zach,

Retter,

Schmoeger

et al. 2023

Wien Klin Wochenschr

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Summary Background Although benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo in clinical practice, factors influencing the pathophysiology remain not fully understood. Objective Here we aim to investigate possible seasonal influences on the occurrence of BPPV in Vienna, a city located in a Central European country with pronounced seasonal fluctuations. Methods We retrospectively investigated data from 503 patients presenting with BPPV to the outpatient clinics of the Medical University of Vienna between 2007 and 2012. Analyses included age, gender, type of BPPV, seasonal assignment, as well as daylight hours and the temperature in Vienna at symptom onset. Results Out of 503 patients (159 male, 344 female, ratio 1:2.2; mean age 60 ± 15.80 years), most patients presented with posterior (89.7%) and left-sided (43.1%) BPPV. There was a significant seasonal difference (χ2p = 0.036) with the majority of symptoms occurring in winter seasons (n = 142), followed by springtime (n = 139). Symptom onset did not correlate with the average temperature (p = 0.24) but on the other hand very well with daylight hours (p < 0.05), which ranged from 8.4 h per day in December, to an average of 15.6 h in July. Conclusion Our results show a seasonal accumulation of BPPV during winter and springtime, which is in line with previous studies from other climatic zones, suggesting an association of this seasonality with varying vitamin D levels.

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Section: Discussionsupporting

confidence: 92%

Seasonality of benign paroxysmal positional vertigo

Zach,

Retter,

Schmoeger

et al. 2023

Wien Klin Wochenschr

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“…The group receiving vitamin D supplementation showed a significant reduction in the frequency of recurrences [ 19 ]. Among these studies, two had a follow-up duration ranging from greater than 6 months to less than a year [ 16 , 26 ], while three had a follow-up time of 1 year or more [ 20 , 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…Rhim reported on a study involving 99 patients with idiopathic BPPV and vitamin D deficiency, where 25 patients received 3 to 4 injections of 200,000 IU of vitamin D3 in the first year, while a control group consisting of 50 patients was selected through frequency matching, resulting in 25 patients in the case group. In terms of relapse rates between the entire case and control groups during different periods (0 to 6 months, 7 to 12 months, 13 to 24 months, and the entire study period), there were no statistically significant differences ( p < 0.531, p < 1.000, p < 0.711, and p < 0.883, respectively), and the distribution of canalolithiasis and cupulolithiasis in BPPV types was 40 and 35, respectively [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation and Recurrence of Benign Paroxysmal Positional Vertigo

Rhim,

Kim

2024

Nutrients

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Positional vertigo manifests as a spinning sensation triggered by changes in head position relative to gravity. Benign paroxysmal positional vertigo (BPPV) is an inner ear disorder characterized by recurrent episodes of positional vertigo. The connection between vitamin D insufficiency/deficiency and the onset and recurrence of BPPV is established. This study aims to assess vitamin D as a recurring factor in BPPV and the efficacy of vitamin D supplementation in preventing its recurrence. A comprehensive literature review on the relationship between vitamin D and BPPV recurrence was conducted, searching PubMed, Embase, Web of Science, and article reference lists for studies published from 2020 to 2023. A total of 79 articles were initially identified through the search, with 12 of them being utilized in the study. Recurrence rates for BPPV varied from 13.7% to 23% for studies with follow-up less than 1 year and 13.3% to 65% for studies with follow-up equal to or exceeding 2 years. Risk factors for BPPV recurrence include advanced age, female sex, hypertension, diabetes mellitus, hyperlipidemia, osteoporosis, and vitamin D deficiency. While earlier studies did not establish a link between low vitamin D levels and initial BPPV occurrence, they did associate recurrent episodes with low vitamin D levels. Recent research indicates that vitamin D supplementation in BPPV patients with deficiency or insufficiency decreases both the numbers of relapsing patients and relapses per patient. To validate these findings across diverse populations, further randomized controlled studies with larger cohorts and extended follow-up durations are essential.

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“…Finally, seven articles were included in the our meta-analysis. [9][10][11][12][13][14][15] These articles comprised 602 and 731 participants in the case and control groups, respectively. A flow diagram describing study search is shown in Figure 1, while characteristics of the seven included articles are summarized in Table 1.…”

Section: Characterization Of the Selected Studiesmentioning

confidence: 99%

“… 8 Talaat et al 11 , Jeong et al 15 showed that improving vitamin D deficiency, via exogenous supplementation, can reduce BPPV recurrence. Conversely, Rhim 14 reported that treating vitamin D deficiency could not reduce the recurrence. Notably, most of the studies on this subject have used small sample sizes, casting doubt on the reliability of the findings.…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D supplementation on benign paroxysmal positional vertigo recurrence: A meta-analysis

Yang

Zhu

et al. 2021

Science Progress

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Benign paroxysmal positional vertigo is characterized by recurrence, which exposes patients to repeated vertigo attacks. Vitamin D deficiency has been found to be a risk factor in benign paroxysmal positional vertigo, although effect of its elimination on recurrence reduction remains unknown. To determine the effect of vitamin D supplementation in preventing recurrence of benign paroxysmal positional vertigo patients with vitamin D deficiency using a meta-analysis study. We searched and retrieved relevant articles from several databases, then used the Cochrane evaluation system or Methodological Index for Non-Randomized Studies (MINORS) to assess the quality of studies. We adopted risk-ratio (RR) with corresponding 95% confidence interval (CI) to determine effect sizes, and further performed statistical analyses under a randomized- or fixed-effects model. Seven studies, comprising 602 and 731 participants in the case and control group respectively, met our inclusion criteria, and were therefore included in the meta-analysis. Assessment based on Cochrane evaluation system or MINORS revealed that most of the studies had high quality. Moreover, the randomized- model revealed that the vitamin D supplementation group had a lower recurrence rate than the control group which did not accepted vitamin D supplementation (RR = 0.41, 95% CI = 0.26–0.65, p < 0.01). Overall, these findings indicate that vitamin D supplementation can significantly lower recurrence in benign paroxysmal positional vertigo and vitamin D deficiency.

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Effect of Vitamin D Injection in Recurrent Benign Paroxysmal Positional Vertigo with Vitamin D Deficiency

Cited by 6 publications

References 26 publications

Seasonality of benign paroxysmal positional vertigo

Seasonality of benign paroxysmal positional vertigo

Vitamin D Supplementation and Recurrence of Benign Paroxysmal Positional Vertigo

Effect of vitamin D supplementation on benign paroxysmal positional vertigo recurrence: A meta-analysis

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