Menière's Disease and Disorders of the Carbohydrate Metabolism Involving the Inner Ear

Albernaz, Pedro Luiz Mangabeira

doi:10.1055/s-0038-1673698

Cited by 2 publications

(2 citation statements)

References 5 publications

(8 reference statements)

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“…In 2019 Albernaz (2019) collected 98 MD patients evaluating familial history of diabetes, glucose tolerance and insulin titration. The results indicated an alteration of the carbohydrate metabolism, which was hypothesized as a possible aetiology for MD.…”

Section: Application Of Metabolomics In Ear Nose and Throatmentioning

confidence: 99%

Metabolomics in Otorhinolaryngology

Noto

Piras

Atzori

et al. 2022

Front. Mol. Biosci.

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Otorhinolaryngology (Ear, Nose and Throat-ENT) focuses on inflammatory, immunological, infectious, and neoplastic disorders of the head and neck and on their medical and surgical therapy. The fields of interest of this discipline are the ear, the nose and its paranasal sinuses, the oral cavity, the pharynx, the larynx, and the neck. Besides surgery, there are many other diagnostic aspects of ENT such as audiology and Vestibology, laryngology, phoniatrics, and rhinology. A new advanced technology, named metabolomics, is significantly impacting the field of ENT. All the “omics” sciences, such as genomics, transcriptomics, and proteomics, converge at the level of metabolomics, which is considered the integration of all “omics.” Its application will change the way several of ENT disorders are diagnosed and treated. This review highlights the power of metabolomics, including its pitfalls and promise, and several of its most relevant applications in ENT to provide a basic understanding of the metabolites associated with these districts. In particular, the attention has been focused on different heterogeneous diseases, from head and neck cancer to allergic rhinitis, hearing loss, obstructive sleep apnea, noise trauma, sinusitis, and Meniere’s disease. In conclusion, metabolomics study indicates a “fil rouge” that links these pathologies to improve three aspects of patient care: diagnostics, prognostics, and therapeutics, which in one word is defined as precision medicine.

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Section: Application Of Metabolomics In Ear Nose and Throatmentioning

confidence: 99%

Metabolomics in Otorhinolaryngology

Noto

Piras

Atzori

et al. 2022

Front. Mol. Biosci.

View full text Add to dashboard Cite

show abstract

“…Обсуждается вклад гиперинсулинемии в патогенез данного заболевания. В ряде исследований показана высокая коморбидность болезни Меньера с нарушениями углеводного обмена, у 72% пациентов с этим заболеванием отмечаются признаки гиперинсулинемии [31,32].…”

Section: метаболические нарушения в патогенезе вестибулярных расстройствunclassified

Metabolic disorders in the pathogenesis of various causes of dizziness and instability

2020

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Dizziness and instability are topical problem in the neurological practice. This health condition invades up to thirty percent of the whole population. However, pathogenic factors of development and tendency to chronic process of these nosological conditions are still poorly researched. The investigation of new pathogenic factors, including metabolic factors, is proceeding. The greatest amount of research was collected for benign paroxysmal positional vertigo (BPPV). The hypothesis of coincidence between BPPV, vitamin D deficiency and osteoporosis was created in 2003. However, the results are controversial. The complex of perfomed investigations let suspect vitamin D deficiency as biomarker of osteoporosis/osteopenia. But some other research works failed to support this conclusion. In some investigations the vitamin D deficiency as factor of recurrence of BPPV was discussed. The new hypothesis was correlation between otoneurological disorders and vitamin D deficiemcy due to its immunomodulation ability was proposed. Considerable part of the article deals with problem of endothelial dysfunction. The data about correlation between oxidative stress and BPPV was published, as far as the data about impact of hypehomocysteinemia to retardation of compensation for vestibular neuritis.

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Menière's Disease and Disorders of the Carbohydrate Metabolism Involving the Inner Ear

Cited by 2 publications

References 5 publications

Metabolomics in Otorhinolaryngology

Metabolomics in Otorhinolaryngology

Metabolic disorders in the pathogenesis of various causes of dizziness and instability

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