New Definition of Fetal Growth Restriction: Consensus Regarding a Major Obstetric Complication

Nardozza, Luciano Marcondes Machado; Zamarian, Ana Cristina Perez; Júnior, Edward Araujo

doi:10.1055/s-0037-1603741

Cited by 6 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although 33.2% of the conceptuses in the case group were SGA, this condition was not a risk factor when adjusted with the other variables. This may be because fetal growth restriction is one of the factors in the causal pathway to prematurity 31 . Furthermore, the number of conceptuses with fetal growth restriction may be greater than shown as it was not possible to measure infants born before 24 weeks gestation (30 perinatal deaths) (data not presented).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for perinatal death in high-risk pregnant women at a tertiary hospital in Curitiba-PR, Brazil: a case-control study

Szyhta

Silva

Alencar

et al. 2023

Ciênc. saúde coletiva

View full text Add to dashboard Cite

A case-control study was carried out to estimate risk factors for perinatal mortality in a referral hospital for high-risk pregnancies in Curitiba-PR. Sociodemographic, maternal, pregnancy and concept characteristics data were obtained from the hospital records of 316 cases and 316 controls from 2013 to 2017. A hierarchical multiple logistic regression analysis was performed, remaining in the final model variables with p < 0.05. The results show an increased risk of perinatal death in mothers with blood type B (OR = 2.82; 95%CI: 1.07-7.43), who did not undergo prenatal care (OR = 30.78; 95%CI: 4.23-224.29), fetuses with congenital malformations (OR = 63.90; 95%CI: 27.32-149.48), born under 28 (OR = 24.21; 95%CI: 1, 10-531.81) and between 28-31 weeks of gestation (OR = 6.03; 95%CI: 1.34-27.17) and birth weight below 1,000g (OR = 51.94; 95%CI: 4.31-626.46), between 1,000-1,499g (OR = 11.17; 95%CI: 2.29-54.41) and between 1,500-2,499g (OR = 2.75; 25-6.06). Concepts of pregnancies with premature outcome, low birth weight and the presence of congenital malformations are the main risk factors for perinatal death. On the other hand, adequate prenatal care is an important protective factor.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors for perinatal death in high-risk pregnant women at a tertiary hospital in Curitiba-PR, Brazil: a case-control study

Szyhta

Silva

Alencar

et al. 2023

Ciênc. saúde coletiva

View full text Add to dashboard Cite

show abstract

“…Entre as doenças infecciosas associadas a malformações encontra-se a sífilis, um grande problema evitável de saúde pública 30 . Apesar de 33,2% dos conceptos do grupo de casos apresentarem restrição do crescimento fetal (PIG), essa condição não se mostrou como risco ao ser ajustada pela presença das demais variáveis, possivelmente porque a restrição do crescimento fetal se encontra no caminho causal da prematuridade 31 . Também é preciso considerar que pode haver um número maior de conceptos com restrição de crescimento intrauterino que não foi possível medir por apresentarem idade gestacional inferior a 24 semanas (30 óbitos perinatais) (dados não mostrados).…”

Section: -Specificityunclassified

Fatores de risco para óbito perinatal em gestantes de alto risco de um hospital terciário de Curitiba-PR, Brasil: estudo caso-controle

Szyhta

Silva

Alencar

et al. 2023

Ciênc. saúde coletiva

View full text Add to dashboard Cite

Resumo Estudo caso-controle com o objetivo de estimar os fatores de risco da mortalidade perinatal em um hospital de referência para gestações de alto risco em Curitiba-PR. Os dados de características sociodemográficas, maternas, da gestação e do concepto foram obtidos dos prontuários hospitalares de 316 casos e 316 controles do período de 2013 a 2017. Foi realizada análise de regressão logística múltipla hierarquizada, permanecendo no modelo final variáveis com p < 0,05. Os resultados mostram aumento do risco de óbito perinatal em mães com tipo sanguíneo B (OR = 2,82; IC95%: 1,07-7,43), que não realizaram pré-natal (OR = 30,78; IC95%: 4,23-224,29), conceptos com malformações congênitas (OR = 63,90; IC95%: 27,32-149,48), nascidos com menos de 28 (OR = 24,21; IC95%: 1,10-531,81) e entre 28-31 semanas de gestação (OR = 6,03; IC95%: 1,34-27,17) e peso ao nascer abaixo de 1.000g (OR = 51,94; IC95%: 4,31-626,46), entre 1.000-1.499g (OR = 11,17; IC95%: 2,29-54,41) e entre 1.500-2.499g (OR = 2,75; IC95%: 1,25-6,06). Conceptos de gestações com desfecho prematuro, baixo peso ao nascer e presença de malformações congênitas são os principais fatores de risco para o óbito perinatal. Em contrapartida, a assistência pré-natal adequada é importante fator de proteção.

show abstract

“…IUGR refers to a somehow loosely defined condition in which the unborn baby is smaller than expected for his or her gestational age ( Nardozza et al, 2017 ). IUGR babies typically have an estimated weight that falls below that of 90% of unborn babies of the same gestational age.…”

Section: Introductionmentioning

confidence: 99%

Urothelial Cancer Associated 1 (UCA1) and miR-193 Are Two Non-coding RNAs Involved in Trophoblast Fusion and Placental Diseases

Apicella

Jacques

Gascoin

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

A bioinformatics screen for non-coding genes was performed from microarrays analyzing on the one hand trophoblast fusion in the BeWo cell model, and on the other hand, placental diseases (preeclampsia and Intra-Uterine Growth Restriction). Intersecting the deregulated genes allowed to identify two miRNA (mir193b and miR365a) and one long non-coding RNA (UCA1) that are pivotal for trophoblast fusion, and deregulated in placental diseases. We show that miR-193b is a hub for the down-regulation of 135 cell targets mainly involved in cell cycle progression and energy usage/nutrient transport. UCA1 was explored by siRNA knock-down in the BeWo cell model. We show that its down-regulation is associated with the deregulation of important trophoblast physiology genes, involved in differentiation, proliferation, oxidative stress, vacuolization, membrane repair and endocrine production. Overall, UCA1 knockdown leads to an incomplete gene expression profile modification of trophoblast cells when they are induced to fuse into syncytiotrophoblast. Then we performed the same type of analysis in cells overexpressing one of the two major isoforms of the STOX1 transcription factor, STOX1A and STOX1B (associated previously to impaired trophoblast fusion). We could show that when STOX1B is abundant, the effects of UCA1 down-regulation on forskolin response are alleviated.

show abstract

New Definition of Fetal Growth Restriction: Consensus Regarding a Major Obstetric Complication

Cited by 6 publications

References 9 publications

Risk factors for perinatal death in high-risk pregnant women at a tertiary hospital in Curitiba-PR, Brazil: a case-control study

Risk factors for perinatal death in high-risk pregnant women at a tertiary hospital in Curitiba-PR, Brazil: a case-control study

Fatores de risco para óbito perinatal em gestantes de alto risco de um hospital terciário de Curitiba-PR, Brasil: estudo caso-controle

Urothelial Cancer Associated 1 (UCA1) and miR-193 Are Two Non-coding RNAs Involved in Trophoblast Fusion and Placental Diseases

Contact Info

Product

Resources

About