An Aggressive Plasmablastic Lymphoma of the Oral Cavity as Primary Manifestation of Acquired Immunodeficiency Syndrome: Case Report and Literature Review

Corti, Marcelo; Minué, Gonzalo; Campitelli, Anthony; Narbaitz, Marina; Gilardi, Leonardo

doi:10.1055/s-0034-1397335

Cited by 20 publications

(12 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our cohort, we found two HIV-positive patients. One of them was diagnosed with a nodal DLBCL and the other with nodal plasmablastic lymphoma (PBL), an aggressive and rare DLBCL subtype that is commonly found in patients with HIV [24].…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation and characteristics of lymphoma in the head and neck region

et al. 2019

View full text Add to dashboard Cite

BackgroundThe study analyses clinical characteristics of histologically defined head and neck (H&N) lymphoma to raise the awareness of ENT specialists to the leading symptoms.MethodFrom 2003 to 2011, all patients with histologically defined H&N lymphoma from our clinic were evaluated.ResultsThis study identified 221 patients with H&N lymphoma comprising 193 non-Hodgkin lymphomas (NHL) and 28 Hodgkin lymphomas (HL). Among NHL there were 77 indolent (iNHL), 110 aggressive (aNHL), six highly aggressive NHL and further 28 HL. Patients with highly aggressive NHL and HL were significantly younger (p < 0.0001). Corresponding to the leading symptoms, we found nodal and extranodal involvement. NHL demonstrated manifestation in neck lymph nodes, tonsils, major salivary glands, sinonasal-system and hypopharynx/larynx. HL showed exclusive manifestation in lymph nodes of the neck and the tonsils (p < 0.0001). The mean time from first symptoms to diagnosis ranged from 1.5 ± 0.7 months in highly aggressive lymphoma to 7.5 ± 11.5 months in iNHL.ConclusionsThe variable clinical presentation of lymphoma is a challenge for the ENT specialist. Fast diagnosis is crucial for rapid treatment, especially in highly aggressive NHL like the Burkitt-lymphoma and HL. A standardized medical history, clinical examination and imaging evaluations paired with patient’s signs, symptoms and demographic knowledge might indicate lymphoma. Biopsies in the H&N region should always be immediately performed in suspicious findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical presentation and characteristics of lymphoma in the head and neck region

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The AIDS-related NHL of the head and neck often presents as a large mass with bone destruction of the maxilla and sinuses. Inside the oral cavity, this large mass usually involves the gums and hard palate presenting as ulcerative lesions [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with acquired immunodeficiency syndrome (AIDS) have a higher risk to develop Non-Hodgkin’s lymphoma [ 12 ], about 100–200 times the risk of the general population [ 13 ]. This malignancy has been reported as the second most common in this group of patients, Kaposi’s sarcoma being the most common [ 13 – 14 ], and the extranodal presentation occuring more commonly in 70–80% of the cases [ 12 ]. In comparison with the general population, AIDS-related lymphomas have a rapid progression, bad response to the treatment, high relapse rates and overall poor prognosis [13 and 15].…”

Section: Introductionmentioning

confidence: 99%

Oral manifestations of lymphoma: a systematic review

Silva¹,

Ferreira²,

Leite³

et al. 2016

ecancer

View full text Add to dashboard Cite

Lymphoma is a malignant disease with two forms: Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). Non-Hodgkin’s lymphoma is diagnosed in extranodal sites in 40% of cases, and the head and neck region is the second most affected, with an incidence of 11–33%, while HL has a very low incidence in extranodal sites (1–4%). The aim of this study was to identify the oral manifestations of lymphoma through a systematic literature review, which we conducted using the PubMed, Lilacs, Embase, and Cochrane Library databases. We found 1456 articles, from which we selected 73. Among the intraoral findings, the most frequent were ulcerations, pain, swelling, and tooth mobility, while the extraoral findings included facial asymmetry and cervical, submandibular, and submental lymphadenopathy. Among the few studies reporting imaging findings, the most cited lesions included hypodense lesions with diffuse boundaries, bone resorptions, and tooth displacements. The publications reviewed highlight gaps in the areas of early detection, diagnosis, and proper treatment.

show abstract

“…There was also a case of PEL in an HIV positive patient [ 159 ], and a multiple myeloma patient with a bone marrow KSHV PCR positive [ 160 ]. We found three KSHV positive MCD from Argentina, two PEL and two KSHV positive DLBCL, all in HIV positive patients [ 13 , 165 , 166 , 167 ]. One of the DLBCL was also positive to EBV infection [ 164 ].…”

Section: Kaposi Sarcoma Human Herpesvirusmentioning

confidence: 99%

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

View full text Add to dashboard Cite

The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations.

show abstract

An Aggressive Plasmablastic Lymphoma of the Oral Cavity as Primary Manifestation of Acquired Immunodeficiency Syndrome: Case Report and Literature Review

Cited by 20 publications

References 17 publications

Clinical presentation and characteristics of lymphoma in the head and neck region

Clinical presentation and characteristics of lymphoma in the head and neck region

Oral manifestations of lymphoma: a systematic review

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Contact Info

Product

Resources

About