Primary Extranodal Non-Hodgkin Lymphoma of the Head and Neck in Patients with Acquired Immunodeficiency Syndrome: A Clinicopathologic Study of 24 Patients in a Single Hospital of Infectious Diseases in Argentina

Corti, Marcelo; Villafañe, María F.; Bistmans, Alicia; Narbaitz, Marina; Gilardi, Leonardo

doi:10.1055/s-0034-1373782

Cited by 11 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NHL is not a single disease, but a complex and diverse group which encompasses more than 65 different subtypes, and this may explain its predominance when compared to HL [ 6 ]. Other reasons may be attributed to the prevailing HIV pandemic and an aging world population due to low immunity [ 18 ]. The difference in the distribution of lymphomas in different countries shows that both genetic and environmental factors may play a role in the development of lymphomas [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia

Kafita¹,

Kaile²,

Malyangu³

et al. 2018

Pan Afr Med J

View full text Add to dashboard Cite

IntroductionEpstein-Barr virus (EBV) is a ubiquitous virus that infects more than 90% of the world's population, and is implicated in lymphoma pathogenesis. However, in Zambia during the diagnosis of these lymphomas, the association of the virus with the lymphomas is not established. Since most patients with lymphomas have poor prognosis, the identification of the virus within the lymphoma lesion will allow for more targeted therapy. The aim of this study was to provide evidence of the presence of the EBV in lymphomas diagnosed at the University Teaching Hospital (UTH) in Lusaka, Zambia.MethodsOne hundred and fifty archival formalin-fixed paraffin embedded suspected lymphoma tissues stored over a 4-year period in the Histopathology Laboratory at the UTH in Lusaka, Zambia, were analysed. Histological methods were used to identify the lymphomas, and the virus was detected using Polymerase Chain Reaction (PCR). Subtyping of the virus was achieved through DNA sequencing of the EBNA-2 region of the viral genome. Chi square or fisher's exact test was used to evaluate the association between EBV status, type of lymphoma and gender.ResultsThe majority of the lymphomas identified were non-Hodgkin's lymphoma (NHL) (80%) followed by Hodgkin's lymphoma (HL) (20%). EBV was detected in 51.8% of the cases, 54.5% of which were associated with NHL cases, while 40.9% associated with HL cases. The predominant subtype of the virus in both types of lymphomas was subtype 1. One of the lymphoma cases harboured both subtype 1 and 2 of the virus.ConclusionThis study showed that EBV is closely associated with lymphomas. Therefore, providing evidence of the presence of the virus in lymphoma tissues will aid in targeted therapy. To our knowledge this is the first time such data has been generated in Zambia.

show abstract

Section: Discussionmentioning

confidence: 99%

Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia

Kafita¹,

Kaile²,

Malyangu³

et al. 2018

Pan Afr Med J

View full text Add to dashboard Cite

show abstract

“…Within this group, there has been a decrease in the incidence of Kaposís sarcoma, whereas similar declines in Hodgkin's lymphoma and NHL have yet to be confirmed. 15 16 …”

Section: Literature Reviewmentioning

confidence: 99%

“… 25 26 Plasmablastic lymphoma, a B cell lymphoma with a high proportion of plasmablastic lymphocytes, is the most common HIV-associated subtype in this location. 15 27 Constitutional symptoms such as fever and night sweats are frequent in PBL. Its typical appearance is a nonspecific ulceration that spreads rapidly and may eventually lead to hemorrhage, necrosis, and lytic bone destruction.…”

Section: Literature Reviewmentioning

confidence: 99%

Head and Neck Lymphomas in HIV Patients: a Clinical Perspective

Oishi

Bagán

Javier

et al. 2017

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

Introduction Because of the many HIV-related malignancies, the diagnosis and treatment of lymphoma in patients infected with human immunodeficiency virus are challenging. Objective Here, we review current knowledge of the pathogenesis, epidemiology, symptomatology, diagnosis, and treatment of head and neck lymphomas in HIV patients from a clinical perspective. Data Synthesis Although Hodgkin's lymphoma is not an AIDS-defining neoplasm, its prevalence is ten times higher in HIV patients than in the general population. NHL is the second most common malignancy in HIV patients, after Kaposi's sarcoma. In this group of patients, NHL is characterized by rapid progression, frequent extranodal involvement, and a poor outcome. HIV-related salivary gland disease is a benign condition that shares some features with lymphomas and is considered in their differential diagnosis. Conclusion The otolaryngologist may be the first clinician to diagnose head and neck lymphomas. The increasing survival of HIV patients implies clinical and epidemiological changes in the behavior of this disease. Early diagnosis is important to improve the prognosis and avoid the propagation of HIV infection.

show abstract

“…In the general population, extranodal NHL comprise 24 to 48% of all NHL. 7 There has been a distinction between primary DLBCL, presenting de novo , and secondary DLBCL. In most cases, patients present with localized disease.…”

Section: Resultsmentioning

confidence: 99%

Extranodal diffuse large B-cell lymphomas: A retrospective case series and review of the literature

et al. 2018

View full text Add to dashboard Cite

Non-Hodgkin lymphomas commonly show extranodal involvement (25-30%) but primary diffuse large B-cell lymphomas (DLBCL) with extranodal localization represent clinically and molecularly distinct entities. The present study involved retrospective analysis of case records of 4 patients who were diagnosed with extranodal DLBCL between 2010 and 2016 at the Medical Oncology and Hematology Departments of the Ioannina University Hospital, Greece. Median age of presentation was 69 years (range 60-77 years). There were 2 males and 2 females. The sites of DLBCL involvement included adrenal gland, mandible, cervix uteri, and ileum. Two patients had B symptoms while none had bone marrow involvement. After staging workup, all the patients fell into IE stage. The treatment approach included chemotherapy combined with rituximab (R), whereas one patient received additionally irradiation therapy. Post-treatment positron emission tomography-computed tomography scan was performed in 3 patients. In terms of the outcome, 3 patients are alive in complete response, whereas one was lost in follow-up. Further prospective data analyses are required so as to better elucidate the biology and course of extranodal DLBCL.

show abstract

Primary Extranodal Non-Hodgkin Lymphoma of the Head and Neck in Patients with Acquired Immunodeficiency Syndrome: A Clinicopathologic Study of 24 Patients in a Single Hospital of Infectious Diseases in Argentina

Cited by 11 publications

References 21 publications

Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia

Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia

Head and Neck Lymphomas in HIV Patients: a Clinical Perspective

Extranodal diffuse large B-cell lymphomas: A retrospective case series and review of the literature

Contact Info

Product

Resources

About