On shelf stability of freeze-dried poly(methylidene malonate 2.1.2) nanoparticles

Freeze-Drying of Nanosuspensions, 1: Freezing Rate Versus Formulation Design as Critical Factors to Preserve the Original Particle Size Distribution

“…A commonly used drying technology applied to stabilize nanosuspensions is freeze-drying. [12][13][14][15] However, the freeze-drying process also induces freezing and drying stress which, in turn, is known to influence the physical stability of a drug nanosuspension. 10 Consequently, a poor formulation or process design would foster aggregation or particle fusion in the final drug product.…”

Development of α-Tocopherol Acetate Nanoparticles: Influence of Preparative Processes

“…Studies have shown that the mass median diameters of aerosols generated upon nebulization were (2-15) folds larger than primary geometric particle diameter (McCallion, Taylor, Thomas, & Taylor, 1996;Bosquillon et al, 2004). Therefore, and in order to obtain aerosolized particles of 1.5-2 μm, nanoparticles' mean size should be between 500 and 700 nm, taking into account that nanoparticles freeze-drying is performed without any size alterations (Auvillain, Cavé, Fessi, & Devissaguet, 1989;Roy et al, 1997).…”

A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases

“…PMM2.1.2 is a synthetic polymer that has been mainly used for the manufacture of particulates systems. 127 Its use for the development of intraocular implants has been advocated since it has been demonstrated to be nontoxic and biodegradable leading to the formation of nontoxic products including ethanol and glycolic acid. 128,129 The scleral discoid device displayed superior physicomechanical properties adapted for in vivo intraocular implantation when high molecular mass PMM2.1.2 (100-150 kDa) associated with ethoxylated derivatives of stearic acid Figure 11.…”