Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography–electrospray ionization tandem mass spectrometry

Miao, Xiaofei; Koenig, Brenda G.; Metcalfe, Chris D.

doi:10.1016/s0021-9673(02)00088-2

Cited by 223 publications

(127 citation statements)

References 16 publications

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“…Among the studied substances, the heteroatom content and the chemical functionalities revealed by the hydroxyl and carboxylic acid moieties makes them polar, ionisable molecules with physicochemical properties that could largely explained their occurrence by our group [10] and other Canadian researchers [17,18] in sewage treatment plants. Their reported properties, coupled with trace quantities, create unique challenges for both removal processes and analytical detection.…”

Section: Properties and Removal Of Pharmaceuticals From Wastewatermentioning

confidence: 80%

Persistence and fate of highly soluble pharmaceutical products in various types of municipal wastewater treatment plants

Gagnon¹,

Lajeunesse²

2008

WIT Transactions on Ecology and the Environment

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Municipal effluents are important source of contaminants including many socalled Pharmaceutical and Personal Care Products (PPCPs) substances, whose potential impacts on the receiving environment are poorly understood. New emerging substances, in the form of pharmaceutical drugs like antibiotics, antiinflammatory, and anti-convulsive, are now being frequently measured in these wastewaters. While PPCPs substances undergo major transformation at the treatment plant and again in the receiving waters, their bioavailability and toxicity may be modified considerably. The influence of different wastewater treatment processes on pharmaceutical products was investigated. Pharmaceutical substances such as clofibric acid, carbamazepine, diclofenac, ibuprofen and naproxen were found in the Montreal physicochemical primarytreated effluents at concentrations ranging from 13 to 3522 ng/L. Most of the substances were eliminated at a rate lower than 10%. Biological treatments (aerobic conditions) with activated sludge resulted in much better removal rates (> 50%) for those studied substances. Interestingly, this type of process showed some selectivity with respect to the size and polarity of the removed substances; the smallest and most polar substances were removed at better rates, while the persistent carbamazepine (273-483 ng/L) and diclofenac (52-68 ng/L) were poorly removed. In the case of treatment by aerated lagoons, the most abundant substances were hydroxy-ibuprofen (339-3938 ng/L), naproxen (16-763 n/L) and carbamazepine (164-425 ng/L). To assess the impacts of all these contaminants on the environment and human health, we need to better understand the chemical and physical transformations occurring at the treatment plant and in the receiving waters.

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Section: Properties and Removal Of Pharmaceuticals From Wastewatermentioning

confidence: 80%

Persistence and fate of highly soluble pharmaceutical products in various types of municipal wastewater treatment plants

Gagnon¹,

Lajeunesse²

2008

WIT Transactions on Ecology and the Environment

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“…These ratios were plotted versus the irradiation times to make the photodecomposition curve of ketoprofen and the generation curve of the photo-degradation product A. 16,20,21) Off-Line Photo-Irradiation/ESR Experiments. Sample Preparation Ketoprofen, oxybenzone, a-tocopherol, flavone and phenothiazine were each dissolved in acetonitrile, quercetin and allopurinol were each dissolved in DMSO/water (1 : 1), and chloropromazine and l-histidine were each dissolved in water.…”

Section: Ketoprofen [(Rs)-2-(3-benzoylphenyl)mentioning

confidence: 99%

Study of Compounds Suppressing Free Radical Generation from UV-Exposed Ketoprofen

Nakajima

Tahara

Yoshimura

et al. 2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Além disso, na parte da identificação dos compostos destaca-se a cromatografia líquida acoplada à espectrometria de massa como técnica, que permite a identificação e a possibilidade de rastreamento dos micropoluentes orgânicos polares sem derivatização (Miao et al, 2002). A partir disso, em diversos países, são realizadas inúmeras análises afim de se estabelecer padrões de análise e verificar a qualidade das águas e efluentes.…”

Section: Introductionunclassified

Toxicidade ambiental de efluentes advindo de diferentes laboratórios de uma farmácia magistral

Pinto¹,

Cardozo²,

Soares³

et al. 2016

Rev. ambiente água

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RESUMOHá uma crescente preocupação com os chamados "poluentes emergentes" na produção de medicamentos. Eles chegam ao meio ambiente a partir do descarte doméstico ou a partir das sobras geradas na produção de fármacos. Em pequenas concentrações da ordem de microgramas por litro ou inferiores, ou seja, concentrações não efetivas a curto prazo em termos de resposta biológica em seres humanos, podem causar grandes impactos no meio ambiente pela exposição crônica. O objetivo deste trabalho foi avaliar o risco de contaminação de efluentes pelo lançamento dos dejetos brutos da produção de medicamentos em pequena escala, por farmácias de manipulação, com base na avaliação da ecotoxicicidade pelo biomonitoramento de algas Euglena gracilis, e investigar os impactos apresentados sobre o comportamento e as alterações no processo de fotossíntese. Amostras de quatro laboratórios de diferentes demandas foram analisadas. As alterações comportamentais (velocidade de subida à superfície, r-value e velocidade de movimento) das algas foram biomonitoradas pelo NG-TOX e os parâmetros de fotossíntese foram medidos com o fluorímetro de pulso e amplitude modulada (PAM). Os resultados demonstraram que o efluente do laboratório de hormônios, que teve uma baixa produção semestral, apresentou pouco impacto, já o efluente do laboratório de psicotrópicos, mesmo com demanda intermediária, apresentou impacto significante sobre o comportamento e a atividade fotossintética das algas. A diferença de comportamento observada entre os diferentes setores de fármacos demonstra que os impactos e os possíveis riscos ambientais são diferentes para cada setor. A demanda e as diferentes substâncias manipuladas podem ser determinantes na classificação de risco e na escolha dos métodos de descontaminação.Palavras-chave: biomonitoramento, descarte de medicamentos, ecotoxicidade, poluentes emergentes. Environmental toxicity of effluents of different laboratories of a compounding pharmacy ABSTRACTThere is a growing concern over so-called "emerging pollutants" in the production of pharmaceuticals. These pollutants reach the environment from household waste or from

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Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography–electrospray ionization tandem mass spectrometry

Cited by 223 publications

References 16 publications

Persistence and fate of highly soluble pharmaceutical products in various types of municipal wastewater treatment plants

Persistence and fate of highly soluble pharmaceutical products in various types of municipal wastewater treatment plants

Study of Compounds Suppressing Free Radical Generation from UV-Exposed Ketoprofen

Toxicidade ambiental de efluentes advindo de diferentes laboratórios de uma farmácia magistral

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