Em tempo: leite humano é a estratégia alimentar para prevenir a enterocolite necrosante

Schanler, Richard J.

doi:10.1016/j.rpped.2015.01.001

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…We conducted a hospital-based prospective nested case-control study of 25 postoperative HAEC cases and 50 control HSCR patients who did not develop postoperative HAEC to investigate the relationship between the enteric microbiome at the time of surgery with risk for developing postoperative HAEC. Breastfeeding is a well-known protective factor for necrotizing enterocolitis, [10][11][12][13] the most common and serious intestinal disease in premature infants, for which altered enteric microbiome has been proposed as an underlying mechanism. 14,15 In the current study, we identified a microbiome signature that might predict the development of postoperative HAEC in HSCR patients and found that exclusive breastfeeding might reduce the risk of HAEC through modulation of the enteric microbiome.…”

Section: Introductionmentioning

confidence: 99%

Prospective study reveals a microbiome signature that predicts the occurrence of post-operative enterocolitis in Hirschsprung disease (HSCR) patients

Tang

Yuan

et al. 2020

Gut Microbes

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Hirschsprung disease (HSCR) is a birth defect with an approximate incidence of 1/5,000 live births, and up to one-third of HSCR patients develop Hirschsprung-associated enterocolitis (HAEC), the leading cause of HSCR-related death. Very little is known about the pathogenesis, prevention, and early diagnosis of HAEC. Here, we used a prospective study to investigate the enteric microbiome composition at the time of surgery as a predictor for developing postoperative HAEC. We identified a microbiome signature containing 21 operational taxonomic units (OTUs) that can potentially predict postoperative HAEC with~85% accuracy. Furthermore, we identified exclusive breastfeeding as a novel protective factor for total HAEC (i.e., preoperative and postoperative HAEC combined). In addition, we discovered that breastfeeding was associated with a lowered risk for HAEC potentially mediated by modulating the gut microbiome composition characterized by a lower abundance of Gram-negative bacteria and lower LPS concentrations. In conclusion, modulating the gut microbiome by encouraging breastfeeding might prevent HAEC progression in HSCR patients.

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Section: Introductionmentioning

confidence: 99%

Prospective study reveals a microbiome signature that predicts the occurrence of post-operative enterocolitis in Hirschsprung disease (HSCR) patients

Tang

Yuan

et al. 2020

Gut Microbes

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“…Regarding eating habits for children, the World Health Organization recommends exclusive breastfeeding until 6 months of age with no liquids other than breast milk, and continue breastfeeding with appropriate supplementary food until two years of age or older [3], given the numerous mutual motherbaby benefits, such as lower risk of postpartum hemorrhage, anemia, breast cancer, and improved metabolic parameters in women; and reduction of occurrences of respiratory, gastrointestinal, sudden death and necrotizing enterocolitis in children [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Food safety and quality of distribution of raw human milk from a University Hospital

et al. 2018

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Objective To evaluate the quality of raw human milk distributed in the Neonatal Intensive Care Unit of a University Hospital of the city of São Paulo. Methods A cross-sectional study with raw human milk samples from mothers who attended the Human Milk Collection Station of a University Hospital, analyzed between May 2016 and January 2017, excluding mothers of twins. The quality of the raw human milk was assessed by verifying the presence of dirt, the coloration of the milk, the titratable acidity using the Dornic method, and through its energy content. Kruskal-Wallis and Mann-Whitney tests were used for the analysis of the energy profile and the degree of Dornic acidity, according to the stage of the raw human milk and the gestational age of the child. Results The study was composed of 40 samples of 40 different women, with a mean age of 27 years, an average of 11.8 years of education, most of them were multiparous and with a partner. Regarding milk analysis, 55.0% was classified as colostrum, 27.5% as mature milk and 17.5% as transitional milk. All samples presented negative results for dirt and normal coloration. The mean milk acidity was 3.24º Dornic and most of the samples were classified as hypercaloric energy content. There was no association between the lactation stage and gestational age with the acidity value and energy content. Conclusion The quality of raw human milk distributed in the Neonatal Intensive Care Unit of the institution evaluated was considered adequate and the samples analyzed had a high energy content and excellent Dornic acidity.

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“…5 The medical literature contains strong evidence about the benefits of breastfeeding, 6 such as optimizing children's growth and physical and mental development and extensive protection against the main diseases that occur later in life. Recent data indicate that breastfeeding is an effective food strategy to prevent necrotizing enterocolitis in the premature population, 7 also presenting advantages for women's health, as for the increase of postpartum infertility period, a greater facility in the pregestational weight acquisition and risk reduction of developing breast and ovarian cancer. 8 Epidemiological studies show that in developing countries, exclusive breastfeeding (EBF) until the sixth month of the baby's life can prevent more than 1.3 million deaths annually in children under five years old, 9 favouring a great reduction in infant mortality rates.…”

Section: Introductionmentioning

confidence: 99%

Reasons for human milk donation according to different per capita income

Santos¹,

Serva²,

Caminha³

2017

Rev. Bras. Saude Mater. Infant.

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Em tempo: leite humano é a estratégia alimentar para prevenir a enterocolite necrosante

Cited by 9 publications

References 20 publications

Prospective study reveals a microbiome signature that predicts the occurrence of post-operative enterocolitis in Hirschsprung disease (HSCR) patients

Prospective study reveals a microbiome signature that predicts the occurrence of post-operative enterocolitis in Hirschsprung disease (HSCR) patients

Food safety and quality of distribution of raw human milk from a University Hospital

Reasons for human milk donation according to different per capita income

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