Poor muscle strength and function in physically inactive childhood-onset systemic lupus erythematosus despite very mild disease

Pinto, Ana Jéssica; Benatti, Fabiana Braga; Roschel, Hamilton; Silva, Clóvis A.; Sallum, Adriana Maluf Elias; Gualano, Bruno

doi:10.1016/j.rbre.2016.07.012

Cited by 4 publications

(6 citation statements)

References 35 publications

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“…Cheung et al showed skeletal muscle mitochondrial dysfunction in SLE patients 4 . Similar to our findings, Pinto et al found weaknesses in the leg and hand grip muscles of SLE patients 7 . Andrews et al also found reduced muscle strength (evaluated knee extension and flexion) which might be associated with impaired physical activity 9 .…”

Section: Discussionsupporting

confidence: 92%

“…Studies evaluating peripheral skeletal muscle abnormalities are commonly focused on the quadriceps femoris muscle and hand-grip muscles. Few studies have demonstrated that the quadriceps femoris is weakened 4 7 9 , however, to the best of our knowledge; no one has investigated specific upper extremity muscle strength. In our study, we found that upper and lower extremity muscle and hand grip strengths were decreased in SLE patients.…”

Section: Discussionmentioning

confidence: 99%

“…The robust literature emphasizes that these common clinical complaints result in a sedentary life, which affects exercise capacity, physical activity, fatigue, and quality of life. These cause the patients into a vicious circle of progressive poor clinical findings [3][4][5][6][7]. Ultimately, the vicious circle result in decreased exercise capacity, physical activity, and quality of life, whereas, increased fatigue levels.…”

Section: Introductionmentioning

confidence: 99%

“…Peripheral muscle abnormalities are related to skeletal muscle mitochondrial dysfunction in patients [4]. Lower peripheral muscle strength has been frequently evaluated in the studies [7,9], however, to the best of our knowledge, there has been no study investigating specific upper peripheral muscle strength. Therefore, there is a need for studies examining both upper and lower muscle strength.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Exercise Capacity, Physical Activity Level and Peripheral Muscle Strength in Systemic Lupus Erythematosus Patients with Healthy Individuals

Sari

Bayram

Oskay

et al. 2023

Aktuelle Rheumatologie

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Background This study investigated physical activity, peripheral muscle strength, exercise capacity, sleep, fatigue, anxiety and depression in patients with systemic lupus erythematosus (SLE). Material and Methods Twenty-six patients with SLE, median age 32.5 (25–43) years, and 29 healthy individuals, median age 30 (23–32) years, were included. Exercise capacity (6-minute walk test (6MWT)), peripheral muscle strength (dynamometer), physical activity (Mi Band 4 smart band), fatigue (Fatigue Severity Scale (FSS)), anxiety and depression (Hospital Anxiety Depression scale (HAD)), quality of life (SLE-specific QOL scale (SLEQoL)) and sleep (Pittsburgh Sleep Quality Index (PSQI)) were assessed. Results Demographic characteristics were similar in both groups. 6MWT distance, peripheral muscle strength, physical activity level, SLEQoL and PSQI scores were significantly lower, while FSS and HAD scores were higher in patients with SLE (p<0.05). Moreover, pre-test and post-test heart rates, dyspnea and fatigue severity scores were higher in patients with SLE than in healthy individuals (p<0.05). Conclusion Patients with SLE had lower exercise capacity, muscle strength, physical activity, quality of life and sleep quality, along with more common fatigue, anxiety and depression. Strategies need to be developed to improve these symptoms in patients with SLE for a favourable outcome.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of Exercise Capacity, Physical Activity Level and Peripheral Muscle Strength in Systemic Lupus Erythematosus Patients with Healthy Individuals

Sari

Bayram

Oskay

et al. 2023

Aktuelle Rheumatologie

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“…There was no other study, according to our knowledge, that evaluates the SarQoL total score in SLE subjects with low muscle function. Several studies showed that low muscle strength was consistently related to lower quality of life (SF-36), 9 life satisfaction (value-added activity, VLA), 9 fatigue, 23 and depression 6 in SLE subjects. Improvement of quality of life in SLE subjects with low muscle function through physical exercise and nutritional intervention, although promising, still marred with several limitations, such as small sample size, no reasonable control, contradictive results, short monitoring time, and unspecific health-related quality of life tools used.…”

Section: Discussionmentioning

confidence: 99%

The impact of low muscle function on health-related quality of life in Indonesian women with systemic lupus erythematosus

Sumantri

Rengganis

Laksmi

et al. 2021

Lupus

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Objective There was no study aimed at evaluating the effect of muscle function on SLE patients' quality of life using the Sarcopenia Quality of Life (SarQoL) questionnaire. Methods This cross-sectional study recruited 61 women with SLE consecutively, muscle function was measured with Jamar handheld-dynamometer and 6-meter walk test, HRQoL was measured with Sarcopenia Quality of Life (SarQoL) questionnaire. The cut-off point for low muscle strength (<18 kg) and low gait speed (<1.0 m/s) was according to the Asian Working Group on Sarcopenia 2019 criteria. Statistical analysis was conducted with a t-test for mean difference, and linear regression was used to adjust confounders (age, protein intake, physical exercise, and disease activity). Results The subjects' mean muscle strength was 19.54 kg (6.94), and 44.3% (n = 27) was found to have low muscle strength. The subjects' mean gait speed was 0.77 m/s (0.20), and 90.3% (n = 55) was found to have low gait speed. The difference of total SarQoL score in subjects with normal and low muscle strength was found to be significant; 74.86 (9.48) vs. 65.49 (15.51) (p = 0.009), and still statistically significant after adjustments with age, protein intake, physical exercise level, and disease activity [B 0.56; 95% CI 0.08–1.03; p = 0.022]. The difference of total SarQoL score in subjects with normal and low physical performance was found to be not significant, 70.67 (11.08) vs. 70.72 (13.56) (p = 0.993). Conclusion There was a significant difference in SarQoL's total score in normal compared with low muscle strength groups of Indonesian women with SLE.

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Physical activity for paediatric rheumatic diseases: standing up against old paradigms

et al. 2017

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Over the past 50 years it has become clear that physical inactivity is associated with chronic disease risk. For several rheumatic diseases, bed rest was traditionally advocated as the best treatment, but several levels of evidence support the imminent paradigm shift from the prescription of bed rest to physical activity in individuals with paediatric rheumatic diseases, in particular juvenile systemic lupus erythematosus, juvenile idiopathic arthritis, juvenile fibromyalgia, and juvenile dermatomyositis. Increasing levels of physical activity can alleviate several symptoms experienced by patients with paediatric rheumatic diseases, such as low aerobic fitness, pain, fatigue, muscle weakness and poor health-related quality of life. Moreover, the propensity of patients with paediatric rheumatic diseases to be hypoactive - often due to social self-isolation, overprotection, and fear and/or ignorance on the part of parents, teachers and health practitioners - can be detrimental to general disease symptoms and function. In support of this rationale, a growing number of studies have demonstrated that the systemic benefits of exercise training clearly outweigh the risks in these diseases. In this sense, health professionals are advised to assess, track and fight against physical inactivity and sedentary behaviour on a routine basis, as they are invaluable health risk parameters in rheumatology.

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Poor muscle strength and function in physically inactive childhood-onset systemic lupus erythematosus despite very mild disease

Cited by 4 publications

References 35 publications

Comparison of Exercise Capacity, Physical Activity Level and Peripheral Muscle Strength in Systemic Lupus Erythematosus Patients with Healthy Individuals

Comparison of Exercise Capacity, Physical Activity Level and Peripheral Muscle Strength in Systemic Lupus Erythematosus Patients with Healthy Individuals

The impact of low muscle function on health-related quality of life in Indonesian women with systemic lupus erythematosus

Physical activity for paediatric rheumatic diseases: standing up against old paradigms

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