Ozone decreases sperm quality in systemic lupus erythematosus patients

Farhat, Juliana; Farhat, Sylvia Costa Lima; Braga, Alfésio Luís Ferreira; Cocuzza, Marcello; Borba, Eduardo F.; Bonfá, Eloísa; Silva, Clóvis A.

doi:10.1016/j.rbre.2015.08.005

Cited by 3 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies suggested that exposure to NO 2 (or NO x ) and CO were associated with increased abnormalities in sperm morphology, 12,19 but not associated with sperm concentration, count, motility, nor aneuploidy 6,12,19,20,32 , which was in line with our results. In contrast, an in vivo study concluded that NO 2 inhalation might reduce the sperm production in rats; 14 Boggia et al found significantly lower sperm total motility, not sperm count, in occupational NO 2 exposed workers; 33 however, the NO 2 exposures in these two studies tended to be much higher than that in the epidemiological studies for general population, which may partly explain the inconsistence.…”

Section: Discussionsupporting

confidence: 93%

“…18,28 Previous epidemiological studies suggested that SO 2 exposure with 90 days lag was significantly associated with increased abnormalities in sperm morphology 12,19 , but not associated with sperm concentration, nor total motility. 12,19,20 In comparison, Zhang et al found that SO 2 inhalation lowered sperm count and sperm motility in rats, though the decrease of sperm count did not reach statistical significance; 16 another in vivo study reported that SO 2 exposure significantly decreased sperm count, and significantly increased sperm shape abnormality percentage in mice. 17 Our results were consistent with the in vivo studies that SO 2 exposure was significantly associated with sperm count and motility, and inconsistent with results from the epidemiological studies.…”

Section: Discussionmentioning

confidence: 99%

“…6,11 While a study in China and another study in Poland suggested that SO 2 and NO x might adversely affect sperm morphology, rather than sperm concentration or motility, Farhat et al did not observe any significant association for SO 2 and NO 2 exposures in Brazil. 12,19,20 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

Liu

Zhou²,

Ma³

et al. 2017

Environ. Sci. Technol.

View full text Add to dashboard Cite

Evidence concerning the association between ambient gaseous air pollutant exposures and semen quality is sparse, and findings in previous studies remain largely inconsistent. We enrolled 1759 men with 2184 semen examinations at a large reproductive medical center in Wuhan, China between 2013 and 2015. Inverse distance weighting interpolation was performed to estimate individual exposures to SO2, NO2, CO and O3 during the entire period (lag 0–90 days) and key periods (lag 0-9, 10-14, 70-90 days) of sperm development. Linear mixed models were used to analyze exposure-response relationships. SO2 exposure with 0-90 days lag was significantly associated with monotonically decreased sperm concentration (β for each interquartile range increase of exposure: −0.14; 95% CI: −0.23, −0.05), sperm count (−0.21; −0.30, −0.12) and total motile sperm count (−0.16; −0.25, −0.08). Significant associations were observed for total and progressive motility only when SO2 exposure was at the highest quintile (all Ptrend < 0.05). Similar trends were observed for SO2 exposure with 70-90 days lag. NO2, CO, or O3 exposure was not significantly associated with semen quality. Our results suggest that ambient SO2 exposure adversely affects semen quality, and highlight the potential to improve semen quality by reducing ambient SO2 exposure during early stage of sperm development.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

Liu

Zhou²,

Ma³

et al. 2017

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…The inclusion of a confirmed fertile control group with similar age, varicocele prevalence and environmental exposure was relevant here, because these factors may cause adverse effects on semen quality. 10 The exclusion of surgeries, hypothalamic-pituitary-gonadal axis dysfunction and end-stage renal disease was relevant to avoid confounding causes of testicular dysfunction. 4,5,8,9,12,13 BMI was higher in controls than SLE patients; however, no negative effect of BMI on sperm DNA fragmentation was previously described.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6][7] Gonadal dysfunction may affect male SLE patients. [8][9][10][11][12][13] High doses of intravenous cyclophosphamide (ivCYC) treatment (National Institutes of Health -NIH protocol) is the main contributing factor for severe semen abnormalities (including azoospermia), testicular atrophy, high follicle-stimulating hormone (FSH) levels and testicular Sertoli cell dysfunction in these patients. [11][12][13] Recently, sperm DNA integrity analysis has shown better diagnostic and prognostic performance for predicting male reproductive potential.…”

Section: Introductionmentioning

confidence: 99%

Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients

Tiseo

Bonfá

Borba

et al. 2018

Lupus

View full text Add to dashboard Cite

Objective To evaluate sperm DNA fragmentation analysis in non-azoospermic male systemic lupus erythematosus (SLE) patients. Methods Twenty-eight consecutive male SLE patients (American College of Rheumatology criteria) and 34 healthy controls were evaluated for demographic/exposures data, urological evaluation, hormone profile and sperm analysis (including sperm DNA fragmentation). Clinical features, disease activity/damage scores and treatment were also evaluated. Results The median age (33 (20–52) vs. 36.5 (25–54) years, P = 0.329) and frequency of varicocele (25% vs. 32%, P = 0.183) were similar in SLE patients and healthy controls. Sperm DNA fragmentation showed significantly higher levels of cells class III (44 (9–88) vs. 16.5 (0–80)%, P = 0.001) and cell class IV (10.5 (3–86) vs. 7 (0–36)%, P = 0.039) in SLE. The sperm DNA fragmentation index was also significantly higher in SLE patients (62 (31–97) vs. 25.5 (0–100)%, P < 0.001). Conventional sperm parameters (including sperm count, motility and morphology) were similar in both groups. In SLE patients no correlations were observed between sperm DNA fragmentation index and age, disease duration, Systemic Lupus Erythematosus Disease Activity Index 2000 and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index scores, and cumulative dose of prednisone, hydroxychloroquine, intravenous cyclophosphamide, methotrexate, azathioprine and mycophenolate mofetil ( P > 0.05). Further analysis of SLE patients treated with and without intravenous cyclophosphamide showed that total sperm motility was significantly lower in the former group (64% (15–83) vs. 72% (57–86), P = 0.024). The sperm DNA fragmentation index was alike in both groups (52.5 (31–95) vs. 67.5 (34–97)%, P = 0.185). Conclusions To our knowledge, this is the first demonstration that male non-azoospermic SLE patients have increased sperm DNA fragmentation without evident gonadal dysfunction. Intravenous cyclophosphamide does not seem to be a major determinant for this abnormality. Future prospective study is necessary to determine the impact of this alteration in these patients' fertility.

show abstract

Ambient ozone pollution is associated with decreased semen quality: longitudinal analysis of 8945 semen samples from 2015 to 2018 and during pollution-control period in Beijing, China

et al. 2019

View full text Add to dashboard Cite

Previous studies suggest that air pollution has a negative effect on semen quality. However, most studies are cross-sectional and the results are controversial. This study investigated the associations between air pollutants (PM 2.5 , PM 10 , SO 2 , NO 2 , CO, and O 3 ) and semen quality among sperm donation candidates, especially when the air pollution was artificially controlled in Beijing, China. We analyzed 8945 semen samples in the human sperm bank of Peking University Third Hospital (Beijing, China) from October 2015 to May 2018. Air pollution data during the entire period (0–90 days prior) and key stages (0–9, 10–14, and 70–90 days prior) of sperm development were collected from the China National Environmental Monitoring Centre. The association between air pollutants and semen parameters (sperm concentration and progressive motility) was analyzed by a mixed model adjusted for age, abstinence duration, month, and average ambient temperature. Only O 3 during key stages of 0–9 days and 10–14 days and the entire period was negatively associated with sperm concentration between 2015 and 2018 ( P < 0.01). During the period of air pollution control from November 2017 to January 2018, except for the increase in O 3 concentration, other five pollutants’ concentrations decreased compared to those in previous years. In this period, the sperm concentration decreased ( P < 0.001). During the pollution-control period, O 3 exposure 10–14 days prior was negatively associated with sperm concentration (95% CI: −0.399–−0.111; P < 0.001). No significant association was found between the other five pollutants and semen quality during that period. Our study suggested that only O 3 exposure was harmful to semen quality. Therefore, O 3 should not be neglected during pollution control operation.

show abstract

Ozone decreases sperm quality in systemic lupus erythematosus patients

Abstract: Ozone and IVCYC had a consistent adverse effect on semen quality of SLE patients during spermatogenesis. Minimizing exposure to air pollution should be taken into account, especially for patients with chronic systemic inflammatory diseases living in large cities.

Cited by 3 publications

References 35 publications

Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients

Ambient ozone pollution is associated with decreased semen quality: longitudinal analysis of 8945 semen samples from 2015 to 2018 and during pollution-control period in Beijing, China

Contact Info

Product

Resources

About