Is there an association between systemic lupus erythematosus and periodontal disease?

Calderaro, Débora Cerqueira; Ferreira, Gilda Aparecida; Mendonça, Santuza Maria Souza de; Corrêa, Jôice Dias; Santos, Fabrícia Xavier; Sanção, João Guilherme Capinam; Silva, Tarcı́lia Aparecida; Teixeira, Antônio Lúcio

doi:10.1016/j.rbre.2015.08.003

Cited by 7 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, oral manifestations of SLE, including but not limited to mucosal ulcerations, xerostomia, hyposalivation, discoid lesions, cheilitis, and erythematous patches have additionally been noted ( Khatibi et al., 2012 ; Benli et al., 2021 ), further supporting a plausible link between SLE and periodontal disease status. Furthermore, the prevalence of periodontitis in SLE patients is substantial, ranging from 60% to 94% of all SLE patients ( Calderaro et al., 2016 ), and SLE patients additionally exhibit greater periodontal disease severity compared to non-SLE individuals with periodontitis, with greater clinical attachment loss and increased probing pocket depth ( Wang et al., 2015 ; Corrêa et al., 2017 ; Zhang et al., 2017 ). Oral dysbiosis in periodontitis may trigger aberrant inflammatory responses observed in SLE.…”

Section: It’s a Two-way Street: The Roles Of Oral Health In Systemic Health And Vice Versamentioning

confidence: 99%

Periodontal Disease: The Good, The Bad, and The Unknown

Sedghi

Bacino

Kapila

2021

Front. Cell. Infect. Microbiol.

117

View full text Add to dashboard Cite

Periodontal disease is classically characterized by progressive destruction of the soft and hard tissues of the periodontal complex, mediated by an interplay between dysbiotic microbial communities and aberrant immune responses within gingival and periodontal tissues. Putative periodontal pathogens are enriched as the resident oral microbiota becomes dysbiotic and inflammatory responses evoke tissue destruction, thus inducing an unremitting positive feedback loop of proteolysis, inflammation, and enrichment for periodontal pathogens. Keystone microbial pathogens and sustained gingival inflammation are critical to periodontal disease progression. However, recent studies have revealed the importance of previously unidentified microbes involved in disease progression, including various viruses, phages and bacterial species. Moreover, newly identified immunological and genetic mechanisms, as well as environmental host factors, including diet and lifestyle, have been discerned in recent years as further contributory factors in periodontitis. These factors have collectively expanded the established narrative of periodontal disease progression. In line with this, new ideologies related to maintaining periodontal health and treating existing disease have been explored, such as the application of oral probiotics, to limit and attenuate disease progression. The role of systemic host pathologies, such as autoimmune disorders and diabetes, in periodontal disease pathogenesis has been well noted. Recent studies have additionally identified the reciprocated importance of periodontal disease in potentiating systemic disease states at distal sites, such as in Alzheimer’s disease, inflammatory bowel diseases, and oral cancer, further highlighting the importance of the oral cavity in systemic health. Here we review long-standing knowledge of periodontal disease progression while integrating novel research concepts that have broadened our understanding of periodontal health and disease. Further, we delve into innovative hypotheses that may evolve to address significant gaps in the foundational knowledge of periodontal disease.

show abstract

Section: It’s a Two-way Street: The Roles Of Oral Health In Systemic Health And Vice Versamentioning

confidence: 99%

Periodontal Disease: The Good, The Bad, and The Unknown

Sedghi

Bacino

Kapila

2021

Front. Cell. Infect. Microbiol.

117

View full text Add to dashboard Cite

show abstract

“…The limitations of the present investigation are the small sample size and the retrospective nature of the study. Prior studies examining periodontal disease in patients with lupus reported conflicting results [40][41][42]. High variance in the clinical research criteria for severity of periodontal disease might play a role in the results.…”

Section: Discussionmentioning

confidence: 94%

Periodontal disease defects and mandibular cortical index in lupus patients

Braga¹,

Morita²,

Munhoz³

et al. 2019

BDS

View full text Add to dashboard Cite

Objective:Systemic lupus erythematosus is an autoimmune disease that affects multiple organs. It is well known that lupus patients have higher risk of osteoporosis, but if the disease affects mandibular cortical bone and alveolar bone is not fully established. The objective of this study was to evaluate periodontal disease defects and mandibular osteoporotic alterations in patients with lupus as compared to healthy patients using panoramic radiographs.Material and Methods:The panoramic radiographs of 72 patients with lupus and 360 healthy patients were evaluated for the presence of bone loss secondary to periodontal disease, classified as horizontal and vertical bone loss. We also assessed mandibular osteoporotic alterations by using the mandibular cortical index. Logistic regression analysis was applied to estimate the risk of mandibular osteoporotic alterations as well as horizontal and vertical bone loss in patients with lupus as compared to healthy patients.Results:There were no statistically significant differences between groups in the presence of horizontal bone defects and mandibular cortical indexes. However, patients with lupus demonstrated that patients with lupus were 2.17 more likely to present vertical bone loss than healthy patients.Conclusions:Patients with lupus might have higher risk of vertical bone loss than healthy patients due to pathophysiology of their disease. Further larger prospective studies should be performed to confirm our findings.

show abstract

“…The most studied clinical parameters of PD were pocket depth, bleeding on probing, gingival recession, and clinical attachment loss, which is the representative of cumulative periodontal destruction. According to literature reports, the prevalence of periodontitis in SLE patients varies between 60% and 94% [ 30 ]. Other studies have also reported the increased prevalence of PD in the SLE patients compared to the healthy controls [ 31 , 32 , 33 , 34 , 35 ].…”

Section: Epidemiological Evidence For the Association Between Pd Parameters And Slementioning

confidence: 99%

“…Moreover, reduced periodontal probing depths in the SLE patients (compared to the control group) was noticed [ 32 , 37 , 38 , 39 , 40 ]. Severity of the periodontal parameters monitored was similar in the SLE patients and the control subjects; however, chronic periodontitis occurred earlier in the SLE patients [ 30 ]. Absence of a statistically significant difference between the results from controls and SLE cases could be ascribed to the use of various anti-inflammatory drugs.…”

Section: Epidemiological Evidence For the Association Between Pd Parameters And Slementioning

confidence: 99%

Systemic Lupus Erythematosus and Periodontal Disease: A Complex Clinical and Biological Interplay

Sojod

Nagano

Lopez

et al. 2021

JCM

View full text Add to dashboard Cite

Reports on the association of periodontal disease (PD) with systemic lupus erythematosus (SLE) have regularly been published. PD is a set of chronic inflammatory conditions linked to a dysbiotic microbial biofilm, which affects the periodontal tissues, resulting eventually in their destruction and contributing to systemic inflammation. SLE is a multi-system chronic inflammatory autoimmune disease that has a wide range of clinical presentations, touching multiple organ systems. Many epidemiological studies have investigated the two-way relationship between PD and SLE, though their results are heterogeneous. SLE and PD are multifactorial conditions and many biological-based hypotheses suggest common physiopathological pathways between the two diseases, including genetics, microbiology, immunity, and environmental common risk factors. By focusing on recent clinical and translational research, this review aimed to discuss and give an overview of the relationship of SLE with PD, as well as looking at the similarities in the immune-pathological aspects and the possible mechanisms connecting the development and progression of both diseases.

show abstract

Is there an association between systemic lupus erythematosus and periodontal disease?

Cited by 7 publications

References 14 publications

Periodontal Disease: The Good, The Bad, and The Unknown

Periodontal Disease: The Good, The Bad, and The Unknown

Periodontal disease defects and mandibular cortical index in lupus patients

Systemic Lupus Erythematosus and Periodontal Disease: A Complex Clinical and Biological Interplay

Contact Info

Product

Resources

About