Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial

Abstract

ObjectiveTo evaluate the effects of platelet-rich plasma (PRP) infiltration in patients with lateral epicondylitis of the elbow, through analysis of the Disabilities of the Arm, Shoulder and Hand (DASH) and Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaires.MethodsSixty patients with lateral epicondylitis of the elbow were prospectively randomized and evaluated after receiving infiltration of three milliliters of PRP, or 0.5% neocaine, or dexamethasone. For the scoring process, the patients were asked to fill out the DASH and PRTEE questionnaires on three occasions: on the day of infiltration and 90 and 180 days afterwards.ResultsAround 81.7% of the patients who underwent the treatment presented some improvement of the symptoms. The statistical tests showed that there was evidence that the cure rate was unrelated to the substance applied (p = 0.62). There was also intersection between the confidence intervals of each group, thus demonstrating that the proportions of patients whose symptoms improved were similar in all the groups.ConclusionAt a significance level of 5%, there was no evidence that one treatment was more effective than another, when assessed using the DASH and PRTEE questionnaires.

Platelet‐Rich Plasma Vs Autologous Blood Vs Corticosteroid Injections in the Treatment of Lateral Epicondylitis: A Systematic Review, Pairwise and Network Meta‐Analysis of Randomized Controlled Trials

“…At this stage, 87 studies that did not meet the inclusion criteria were excluded. Twenty eligible RCTs were included in our network meta‐analysis (Figure ). In 13 PRP trials, the PRP preparation contained a high concentration of leukocytes in three trials and was relatively pure with deleted leukocytes in 10 trials .…”

“…Twenty eligible RCTs were included in our network meta‐analysis (Figure ). In 13 PRP trials, the PRP preparation contained a high concentration of leukocytes in three trials and was relatively pure with deleted leukocytes in 10 trials . Most studies measured outcomes at more than 2 months; only five studies measured outcomes at 3 weeks to 2 months.…”

“…In 13 PRP trials, the PRP preparation contained a high concentration of leukocytes in three trials and was relatively pure with deleted leukocytes in 10 trials . Most studies measured outcomes at more than 2 months; only five studies measured outcomes at 3 weeks to 2 months. The sample size of each treatment group in the trial, average age, and symptom duration varied from 9 to 80, 35.3 to 54 year, and <1 to 35.6 month, respectively.…”

Efficacy of platelet-rich plasma injections for symptomatic tendinopathy: systematic review and meta-analysis of randomised injection-controlled trials

“…[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The most common reasons for exclusion were review paper (53), non-tendinopathy (14), injection of active control (7; eg, whole blood, PRP) and non-randomised study (7). Several manuscripts were excluded from this review because they were superseded by papers from the same study with longer follow-up including de Vos et al 29 30 and Peerbooms et al 31 A flow diagram of study identification and selection is shown in figure 1.…”

Lateral Epi̇kondi̇li̇tli̇ Hastalarda Ağri, Eklem Hareket Açikliği Ve Kas Kuvveti̇ni̇n Günlük Yaşam Akti̇vi̇teleri̇ Üzeri̇ne Etki̇si̇

“…Çalışma hayatında ise performansı etkileyerek iş gücü kaybına ve maliyet artışına neden olmaktadır (11). LE tedavisine yönelik çok sayıda uygulama mevcut olmakla birlikte tedavinin temel prensipleri ağrının giderilmesi, iyileşme sürecinin hızlandırılması, kola yönelik aşırı yüklenmelerin azaltılması ve hastanın günlük yaşam aktivitelerine geri dönüşünün sağlanmasıdır (6,12 Ruh sağlığı 43,0± 10,5 73,5±11,6…”