Plasma concentration of IL-6 and TNF-α and its relationship with zincemia in obese women

Feitosa, Maura Cristina Porto; Lima, Vanessa Batista de Sousa; Neto, José Machado Moita; Marreiro, Dilina do Nascimento

doi:10.1016/j.ramb.2013.03.003

Cited by 25 publications

(12 citation statements)

References 28 publications

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“…TNF-α is a key component of the innate immune system such as IL-1β and IL-8 (18), and serum levels of TNF-α along with other proinflammatory cytokines are known to be elevated in obese individuals (19). Nevertheless, serum TNF-α and IL-8 levels of IIH patients were found to be paradoxically decreased as compared to overweight healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Evidence for potential involvement of pro-inflammatory adipokines in the pathogenesis of idiopathic intracranial hypertension

Samancı

Tüzün

et al. 2016

Cephalalgia

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Background Although specific role players are currently unknown, contribution of inflammatory mediators has been suggested in the pathophysiology of idiopathic intracranial hypertension (IIH), which is a disease more prevalent in obese female individuals of childbearing age. We aimed to investigate the levels of adipokines and cytokines to demonstrate possible markers for inflammation that participate in IIH pathophysiology and their association with clinical features of IIH. Methods IIH patients, diagnosed according to the revised criteria, and age-, gender- and body mass index (BMI)-matched healthy controls were enrolled in this study. Serum samples were evaluated for insulin-like growth factor 1, insulin, nesfatin, adiponectin, interleukin (IL)-1β, IL-6, IL-8, leptin, plasminogen activator inhibitor type-1, resistin, tumour necrosis factor-alpha (TNF-α) and monocyte chemotactic protein 1 via enzyme-linked immunosorbent assay or multiplex immunoassays. Results IL-1β level was significantly higher ( p = 0.012), and IL-8 and TNF-α levels were significantly lower in the IIH group ( p < 0.001 and p = 0.008, respectively) compared to the control group. There were no correlations between the cytokine/adipokine levels and age, BMI, disease duration, and cerebrospinal fluid oligoclonal bands. There were also no significant differences in cytokine and adipokine levels between IIH patients regarding visual impairment. However, statistically significant differences were found between IIH patients with relapse versus healthy controls regarding IL-1β ( p = 0.007), IL-8 ( p = 0.001) and TNF-α ( p = 0.017) levels. Other investigated cytokines and adipokines showed no significant alterations in IIH patients investigated in the remission period. Conclusion Altered serum levels of IL-1β, IL-8 and TNF-α seem to be associated with IIH pathogenesis, and these cytokines may be used as prognostic markers in IIH to predict relapse.

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Section: Discussionmentioning

confidence: 99%

Evidence for potential involvement of pro-inflammatory adipokines in the pathogenesis of idiopathic intracranial hypertension

Samancı

Tüzün

et al. 2016

Cephalalgia

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“…They also conclude that this transporter may be used in insulin resistance treatment. Feitosa et al [ 142 ] have shown that Zip-14 also takes part in zinc homeostasis during inflammation caused by obesity. They also reported elevated plasma concentrations of IL-6, leading to the increased expression of Zip-14 in obese women.…”

Section: Introductionmentioning

confidence: 99%

Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

et al. 2017

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A number of studies have reported that zinc plays a substantial role in the development of metabolic syndrome, taking part in the regulation of cytokine expression, suppressing inflammation, and is also required to activate antioxidant enzymes that scavenge reactive oxygen species, reducing oxidative stress. Zinc also plays a role in the correct functioning of lipid and glucose metabolism, regulating and forming the expression of insulin. In numerous studies, zinc supplementation has been found to improve blood pressure, glucose, and LDL cholesterol serum level. Deeper knowledge of zinc’s properties may help in treating metabolic syndrome, thus protecting against stroke and angina pectoris, and ultimately against death.

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“…Comparable findings in a study of Khaodhiar et al [29], reported that the serum levels of IL-6 best indicate the intensity of the systemic inflammation that develops with increasing levels of obesity, and IL-6 levels was positively correlated with BMI only in subjects with morbid obese. On the other side, Feitosa et al [21] indicated that concentrations of IL-6 in plasma did not show significant differences between women with obesity and controls.…”

Section: Discussionmentioning

confidence: 96%

“…Our results came in concordance with the literature and other previous studies regarding TNF-α levels in class II and III obesity groups. As the majority indicated that women with obesity, BMI ≥ 34.5 kg/m 2 , showed significant increase in TNF-α level [21].…”

Section: Discussionmentioning

confidence: 97%

Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III

et al. 2020

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Obesity is an alarming threat to health in Egypt. More than one in three Egyptians is obese, the highest rate in the world. We aimed to delineate the variability of inflammation and endothelial dysfunction markers among Egyptian females with different obesity classes. Out of 130 females, 70 were categorized into 3 obesity groups: Class I, BMI 30–34.9kg/m2; Class II, BMI 35–39.9 kg/m2 and Class III BMI ≥ 40kg/ m2, besides 60 control subjects. Anthropometric measurements were recorded and serum levels of tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), interleukin 6 (IL-6), IL-12, soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular adhesion molecule 1(sVCAM-1) were assessed among participants. In all three classes of obesity, significant increase (P <0.05) in BMI, waist-hip ratio, fat mass and body fat mass % were noted. CRP and sVCAM-1 levels were increased among the 3 obesity groups. TNF-α levels were increased in class II and III obesity groups. IL-6 and IL-12 levels were elevated in class I and class III groups. While, ICAM-1 levels were increased in class III obesity group. Based on individuals’ BMI, serum levels of TNF-α, CRP, IL-6, IL-12, sVCAM-1 and sICAM-1 are differentially altered with the progression of obesity. We strongly support the hypothesis that, as the obesity rate is still mounting, a subclinical inflammatory reaction has a role in pathogenesis of obesity and emphasize the elevation of endothelial dysfunction in individuals with obesity.

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Plasma concentration of IL-6 and TNF-α and its relationship with zincemia in obese women

Abstract: Obese women presented lower concentrations of erythrocytary zinc than the control group. The study demonstrated a probable influence of the inflammatory process on metabolism of zinc in obese patients.

Cited by 25 publications

References 28 publications

Evidence for potential involvement of pro-inflammatory adipokines in the pathogenesis of idiopathic intracranial hypertension

Evidence for potential involvement of pro-inflammatory adipokines in the pathogenesis of idiopathic intracranial hypertension

Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III

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