Doença hepática gordurosa não alcoólica e sua relação com a síndrome metabólica no pré-operatório de pacientes submetidos à cirurgia bariátrica

Schild, Bruna Z.; Santos, Luciano Neto; Alves, Márcia Keller

doi:10.1016/j.ramb.2012.10.004

Cited by 8 publications

(7 citation statements)

References 23 publications

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“…Reinforcing this finding, Tsunoda et al [20] demonstrated in their study that physical activity, mainly of vigorous intensity, has a positive effect to prevent hepatic steatosis and other liver diseases. This can be explained by the relation of the use of energetic substrates used during the practice of physical activities, which in turn activates the AMP kinase cycle [4].…”

Section: Discussionmentioning

confidence: 78%

“…The plasma level of GGT, associated with low levels of physical activity, has been reported as one of the predictors of diabetes [18]. Some studies show that the regular practice of physical activity can regulate the values of this transaminase [19,20]. Alkaline phosphatase is used in clinical practice to check for possible hepatic damage, but this is more related to the onset and development of osteoarticular diseases [24].…”

Section: Discussionmentioning

confidence: 99%

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Physical activity as a protective factor against development of liver steatosis in patients infected with hepatitis C

Silva

Fernandes

Lima

et al. 2018

Biomedical Human Kinetics

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SummaryStudy aim: Was to verify whether the regular practice of physical activity promotes some protective factor against the development of LS in patients infected with hepatitis C virus (HCV). Materials and method: Clinical data were obtained through medical records available at the Pernambuco Liver Institute. Physical activity levels were obtained through the International Physical Activity Questionnaire (IPAQ) short form to classify the patients according to the guidelines of the American College of Sports Medicine (ACSM). Results: The sample consisted of patients of both genders, over 18 years of age, who had positive anti-HCV, HCV-RNA and confirmatory tests for presence or absence of liver steatosis. 126 patients were included in the study. Patients with liver steatosis (G1) were more frequently male (57%) compared to patients without liver steatosis (G2) (p = 0.02). Physical activity analysis showed significant differences for GGT (p = 0.04), HDL (p = 0.04), AF (p = 0.02), viral genotype 3 (p = 0.04) and waist-to-hip ratio (p = 0.01) in anthropometric data. Correlation analysis showed a significant difference for GGT (r = -0.23; p = 0.01) and total bilirubin (BT) (r = -0.22; p = 0.01). Conclusions: Regular practice of physical activity generates a protective factor against the development of LS in patients infected by the hepatitis C virus and it is associated with the maintenance of variables related to hepatic and biochemical damage in patients infected with HCV.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Physical activity as a protective factor against development of liver steatosis in patients infected with hepatitis C

Silva

Fernandes

Lima

et al. 2018

Biomedical Human Kinetics

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“…Cotrim et al, in a study developed in Brazil, involving 1280 patients, have found a mean age of the individuals with NAFLD of 49.8 years ( 27 ) . Schild et al have shown a linear tendency towards increasing the NAFLD prevalence with the increase in the age range ( 34 ) . In Aracaju, the median age among individuals with non alcoholic liver steatosis was 46 years.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and sonographic changes compatible with fatty liver disease in patients referred for abdominal ultrasound examination in Aracaju, SE

Cruz

Neto

et al. 2016

Radiol Bras

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ObjectiveTo estimate the prevalence and evaluate sonographic findings compatible with changes consistent with hepatic steatosis in patients referred for abdominal ultrasonography at four reference centers in Aracaju, SE, Brazil.Materials and MethodsProspective, descriptive survey, with analytical and quantitative approach, comprising abdominal ultrasonography scans performed with a convex, dynamic 3.75 MHz transducer. Liver dimensions and parenchymal echotexture were evaluated, classifying hepatic steatosis into grades (1, 2 or 3). The SPSS® 22.0 software was used for statistical analysis, adopting p < 0.05 as significance level.ResultsA total of 800 individuals (561 women and 239 men) were evaluated. The prevalence of steatosis was 29.1%, and the male patients were most affected, presenting with more advanced grades of disease (p = 0.021), as follows: 119 grade 1 (51.0%); 94 grade 2 (40.4%); and 20 grade 3 (8.6%). The median age patients' was 46 years.ConclusionIn the present study sample, the prevalence of hepatic steatosis was high, particularly in the male patients. Ultrasonography is suggested as a first choice for the diagnosis of this condition, considering its wide availability, low cost and absence of side effects or risks to the patient.

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“…Schild et al 21 O diagnóstico da Doença Hepática Gordurosa Não Alcoólica pode ser feito por meio de exames; entre eles, o mais eficaz e de menor custo é a ultrassonografia abdominal ou a ecografia, que define o grau da doença, porém apresenta limitações visto que, em alguns casos não identifica a cirrose 20,23,24 . A partir de tal exame, adotam-se as classificações de esteatose hepática grau 1 (leve), grau 2 (moderado) e grau 3 (grave) 13 .…”

Section: Doença Hepática Gordurosa Não Alcoólica E Suas Complicaçõesunclassified

“…O aumento das enzimas alanina aminotransferase (ALT) e aspartato aminotransferase (AST) pode indicar uma lesão no fígado; porém, em alguns casos, permanece com teores normais mesmo em condições de doenças hepáticas 11,20,24 . Um dos fatores que auxiliam na reversão do quadro de Doença Hepática Gordurosa Não Alcoólica é a redução do peso corporal, visto que alguns pacientes com obesidade mórbida ou com um elevado Índice de Massa Corporal (≥35 kg/m 2 ), ao se submeterem a cirurgias bariátricas apresentaram uma melhora significativa de seu quadro clínico 7,21,26 . No estudo 27 realizado com 766 biópsias hepáticas, 93% obtiveram uma melhora do quadro da Doença Hepática Gordurosa Não Alcoólica.…”

Section: Doença Hepática Gordurosa Não Alcoólica E Suas Complicaçõesunclassified

Doença Hepática Gordurosa Não Alcoólica: um problema global de caráter reversível

Barbosa

Almeida

2019

J Health Biol Sci.

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Objetivo: Realizar uma revisão sobre a Doença Hepática Gordurosa Não Alcoólica e sua reversão. Método: Trata-se de uma revisão de literatura narrativa, para o qual se selecionaram alguns livros e artigos publicados nas bases de dados Scielo, Google Acadêmico e Sciencediret nos últimos 11 anos (2008 a 2019), utilizando os descritores: esteatose hepática e doença hepática gordurosa não alcoólica, reversão da esteatose, cirurgia bariátrica e esteatose, atividade física e esteatose. Resultados: Foram revisados 4 livros e 35 artigos, cujas informações ressaltam que vários alimentos com nutrientes e compostos bioativos são importantes para o metabolismo dos lipídios hepáticos, justificando seu consumo na prevenção e/ou reversão da Doença Hepática Gordurosa Não Alcoólica. A redução do peso corporal, mediante alterações do comportamento alimentar ou da cirurgia bariátrica diminui a gordura hepática, porém é necessário um controle rígido e contínuo, visto que o excesso de triacilgliceróis pode voltar a se acumular nos hepatócitos caso os hábitos saudáveis de vida (alimentar e da prática de atividade física) tenham ação descontinuada ou reduzida. Conclusão: A melhor conduta terapêutica para o tratamento e a reversão da Doença Hepática Gordurosa Não Alcoólica baseia-se no consumo alimentar adequado e na prática regular de atividade física de forma contínua.

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Doença hepática gordurosa não alcoólica e sua relação com a síndrome metabólica no pré-operatório de pacientes submetidos à cirurgia bariátrica

Abstract: The results of this study showed that the diagnosis of MS, as well as the presence of disorders associated with this syndrome (obesity, hypertension, and high blood glucose levels) are strongly associated with the presence of NAFLD.

Cited by 8 publications

References 23 publications

Physical activity as a protective factor against development of liver steatosis in patients infected with hepatitis C

Physical activity as a protective factor against development of liver steatosis in patients infected with hepatitis C

Prevalence and sonographic changes compatible with fatty liver disease in patients referred for abdominal ultrasound examination in Aracaju, SE

Doença Hepática Gordurosa Não Alcoólica: um problema global de caráter reversível

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