Manganese superoxide dismutase vs. p53: Regulation of mitochondrial ROS

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

“…33,34) The MnSOD, an important antioxidative enzyme, is reported to regulates ROS metabolism and detoxify mitochondrial ROS. 35) As a consequence, methods that enhance SIRT1 and MnSOD activity are probably have the potential to prevent HFD-induced renal injuries, where resveratrol are demonstrated to have a role in this study.…”

Effect of peroxiredoxin II on the quality and mitochondrial activity of pre-implantation bovine embryos

“…The SOD2, antioxidant enzyme, is transcribed to counterbalance ROS and is located in the mitochondrial matrix (Holley et al, 2010). SOD2 is involved in protecting embryos against oxidative stress through transforming toxic superoxides, a byproduct of the mitochondrial electron transport chain, into hydrogen peroxide (H 2 O 2 ), which is eliminated by catalase or glutathione peroxidase 1 (Guerin et al, 2001).…”

Redox Regulation of T-Cell Function: From Molecular Mechanisms to Significance in Human Health and Disease

“…Polyak et al have shown that p53 can induce the expression of different genes such as proline oxidase, which upregulates ROS production in cancer cells (225,239). The tumor suppresor p53 has also been shown to regulate mitochondrial ROS production by altering the expression of the mitochondrial antioxidant enzyme, manganese superoxide dismutase (MnSOD) (109,240). Therefore, an impaired communication between the mitochondria, p53, and the nucleus is implicated in several disease conditions.…”