Lactate acid level and prognosis of neonatal necrotizing enterocolitis: a retrospective cohort study based on pediatric-specific critical care database

Evaluation of Plasma D-Lactate Level in Preterm Infants with Necrotizing Enterocolitis

“…We also found that plasma D-lactate levels of both first and second samples were significantly higher in the group of patients who died as compared to those of the discharged patients.This came in the same line with Wang et al who reported the same finding (18) . In addition, we reported that plasma levels of D-lactate of the second samples of discharged patients decreased significantly as compared to their first samples, while no significant difference was found between the level of D-lactate of first and second samples of the patients who have died.…”

New insights into intestinal macrophages in necrotizing enterocolitis: the multi-functional role and promising therapeutic application

“…In addition, HMGB1 promotes chemotaxis through RAGE pathway and activates NF-κB signaling pathway to induce inflammation; therefore, targeting HMGB1/RAGE/NF-κB pathway may be one of the measures to reduce intestinal inflammation ( 137 ). Lactate in circulating is the key regulator of HMGB1 secreted by Mφs, and the increase of neonatal lactate levels and the occurrence of sepsis are closely related to the mortality and prognosis of NEC ( 138 , 139 ). During sepsis, Mφs uptake extracellular lactate via monocarboxylate transporters (MCT) to promote HMGB1 lactylation via a p300/CBP-dependent mechanism.…”