Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease

Khan, Shahida; Damanhouri, Ghazi A.; Jameel, Tahir; Halawani, Saeed H.; Ali, Ashraf; Makki, Ahmad; Khan, Sarah

doi:10.1016/j.jped.2022.01.001

Cited by 3 publications

(1 citation statement)

References 25 publications

(26 reference statements)

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“…Moreover, DHA and EPA were shown to downregulate production of reactive oxygen species and were effective scavengers of superoxide anions ( da Silva et al, 2016 ; Richard et al, 2008 ). Indeed, supplementation of ω-3 PUFAs mitigated both systemic inflammation and excessive production of reactive oxygen species in acute and chronic disease states ( Li et al, 2017 ; Alorabi et al, 2022 ; Gortan Cappellari et al, 2022 ; Khan et al, 2022 ). Although few studies have investigated ω-3 PUFA supplementation in IUGR outcomes, extensive literature documenting their antioxidant and anti-inflammatory functions indicate their potential for ameliorating IUGR pathologies.…”

Section: Mitigating the Impact Of Iugr With ω-3 Pufamentioning

confidence: 99%

Dousing the flame: reviewing the mechanisms of inflammatory programming during stress-induced intrauterine growth restriction and the potential for ω-3 polyunsaturated fatty acid intervention

White,

Yates

2023

Front. Physiol.

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Intrauterine growth restriction (IUGR) arises when maternal stressors coincide with peak placental development, leading to placental insufficiency. When the expanding nutrient demands of the growing fetus subsequently exceed the capacity of the stunted placenta, fetal hypoxemia and hypoglycemia result. Poor fetal nutrient status stimulates greater release of inflammatory cytokines and catecholamines, which in turn lead to thrifty growth and metabolic programming that benefits fetal survival but is maladaptive after birth. Specifically, some IUGR fetal tissues develop enriched expression of inflammatory cytokine receptors and other signaling cascade components, which increases inflammatory sensitivity even when circulating inflammatory cytokines are no longer elevated after birth. Recent evidence indicates that greater inflammatory tone contributes to deficits in skeletal muscle growth and metabolism that are characteristic of IUGR offspring. These deficits underlie the metabolic dysfunction that markedly increases risk for metabolic diseases in IUGR-born individuals. The same programming mechanisms yield reduced metabolic efficiency, poor body composition, and inferior carcass quality in IUGR-born livestock. The ω-3 polyunsaturated fatty acids (PUFA) are diet-derived nutraceuticals with anti-inflammatory effects that have been used to improve conditions of chronic systemic inflammation, including intrauterine stress. In this review, we highlight the role of sustained systemic inflammation in the development of IUGR pathologies. We then discuss the potential for ω-3 PUFA supplementation to improve inflammation-mediated growth and metabolic deficits in IUGR offspring, along with potential barriers that must be considered when developing a supplementation strategy.

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Section: Mitigating the Impact Of Iugr With ω-3 Pufamentioning

confidence: 99%

Dousing the flame: reviewing the mechanisms of inflammatory programming during stress-induced intrauterine growth restriction and the potential for ω-3 polyunsaturated fatty acid intervention

White,

Yates

2023

Front. Physiol.

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Clinical Efficacy of Omega-3 Fish Oil Lipid Emulsions Combined with Thymosin Alpha 1 in Severe Acute Pancreatitis Patients

张¹

2022

ACM

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Palatability and Acceptability of Flaxseed-Supplemented Foods in Children with Sickle Cell Disease

et al. 2023

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Omega-3 fatty acids (w3FAs) have demonstrated benefits in several inflammatory disease states; however, limited research has been conducted in sickle cell disease (SCD). While marine-based w3FAs are used, their strong odor and taste are a barrier to long-term use. Plant-based sources, especially those in whole foods, may circumvent this barrier. We tested whether flaxseed (rich source of w3FAs) was acceptable to children with SCD. A cross-sectional tasting trial of flaxseed added to baked products (cookies, pancakes, brownies) or to readily available foods (applesauce, pudding, yogurt) was conducted among 30 children (median age = 13 years) reporting to a clinic for routine follow-up, sick visits, or transfusion for SCD to determine acceptability. A food preference rank scale (1–7) was used to rank products based on taste, sight, smell, and texture. An average score for each product was computed. Children were also asked to rank their top three products. The top-ranked products were flaxseed baked in brownies and cookies and ground flaxseed added to yogurt. More than 80% of participants indicated willingness to be contacted for a follow-up study in which a flaxseed-supplemented diet would be evaluated for mitigation of SCD-associated pain. In conclusion, flaxseed-enriched products are palatable and acceptable in children with SCD.

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Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease

Cited by 3 publications

References 25 publications

Dousing the flame: reviewing the mechanisms of inflammatory programming during stress-induced intrauterine growth restriction and the potential for ω-3 polyunsaturated fatty acid intervention

Dousing the flame: reviewing the mechanisms of inflammatory programming during stress-induced intrauterine growth restriction and the potential for ω-3 polyunsaturated fatty acid intervention

Clinical Efficacy of Omega-3 Fish Oil Lipid Emulsions Combined with Thymosin Alpha 1 in Severe Acute Pancreatitis Patients

Palatability and Acceptability of Flaxseed-Supplemented Foods in Children with Sickle Cell Disease

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