Palatability and Acceptability of Flaxseed-Supplemented Foods in Children with Sickle Cell Disease

Abstract

Omega-3 fatty acids (w3FAs) have demonstrated benefits in several inflammatory disease states; however, limited research has been conducted in sickle cell disease (SCD). While marine-based w3FAs are used, their strong odor and taste are a barrier to long-term use. Plant-based sources, especially those in whole foods, may circumvent this barrier. We tested whether flaxseed (rich source of w3FAs) was acceptable to children with SCD. A cross-sectional tasting trial of flaxseed added to baked products (cookies, pancakes, brownies) or to readily available foods (applesauce, pudding, yogurt) was conducted among 30 children (median age = 13 years) reporting to a clinic for routine follow-up, sick visits, or transfusion for SCD to determine acceptability. A food preference rank scale (1–7) was used to rank products based on taste, sight, smell, and texture. An average score for each product was computed. Children were also asked to rank their top three products. The top-ranked products were flaxseed baked in brownies and cookies and ground flaxseed added to yogurt. More than 80% of participants indicated willingness to be contacted for a follow-up study in which a flaxseed-supplemented diet would be evaluated for mitigation of SCD-associated pain. In conclusion, flaxseed-enriched products are palatable and acceptable in children with SCD.

Palatability and Stability Studies to Optimize a Carvedilol Oral Liquid Formulation for Pediatric Use

“…However, their high sucrose content makes them unsuitable for pediatric patients with diabetes and hereditary fructose intolerance. Moreover, sucrose alters dental plaque pH, leading to tooth enamel dissolution and contributing to dental cavities [ 2 ]. Cherry and strawberry flavors, in combination with a high-intensity sweetener, may suit the United States and European pediatric market.…”

“…Hence, it is often cited as a major cause of non-adherence, especially for geriatric and pediatric populations, who may have swallowing difficulties. An unpalatable formulation can heavily reduce the young patient’s compliance and, consequently, the effectiveness of the therapy [ 2 ].…”