Vitamin A deficiency and association between serum retinol and IGF-1 concentrations in Brazilian children with Down syndrome

Ferraz, Ivan Savioli; Vieira, Débora Mônica Costa; Ciampo, Luíz Antônio Del; Ued, Fábio da Veiga; Almeida, Ane Cristina Fayão; Jordão, Alceu Afonso; Aragon, Davi Casale; Martinez, Edson Zangiacomi; Martinelli, Carlos Eduardo; Nogueira‐de‐Almeida, Carlos Alberto

doi:10.1016/j.jped.2021.04.003

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…In addition, IGF-1 promotes the growth mediated by GH [ 14 ] and induces the occurrence of chondrocyte mitosis, both of which participate in the growth and development of children. Animal experiments have found [ 15 , 16 ] that GHBP, a specific binding protein of GH in plasma, can bind to the GH, which can reduce the fluctuation of GH level caused by the pulsatile secretion of GH in hypophysis and prolong the half-life of GH, thus regulating the GH. GHBP in human is generated by the protein cleavage mechanism of growth hormone receptor (GHR), which can be used to reflect the status of GHR in the body.…”

Section: Discussionmentioning

confidence: 99%

Correlation Study between Levels of Gastrin, Serum IGF-1, and GHBP and Growth and Development in Children with Short Stature Based on Big Data Analysis

Chen

2022

Disease Markers

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Objective. To analyze the correlation between the levels of gastrin, serum IGF-1, and GHBP and growth and development in children with short stature (SS) using the big data. Methods. By means of retrospective analysis, the clinical data of 42 children with SS admitted to our hospital from October 2020 to October 2021 were selected as the study group, while 30 children with the healthy physical examination results in the corresponding period were selected as the control group to measure the growth and development indices and the levels of gastrin, serum IGF-1, and GHBP. The Pearson correlation analysis was used for the relationship between the levels of gastrin, serum IGF-1, and GHBP and growth and development indices in children with SS, and the targeted intervention measures were formulated by the analysis of experimental data. Results. Compared with the study group, the height, weight, and bone mineral density (BMD) Z -scores of children in the control group were obviously higher ( P < 0.001 ). The levels of gastrin, serum IGF-1, and GHBP in the study group were markedly lower than those in the control group ( P < 0.05 ). The Pearson correlation analysis showed that the gastrin, serum IGF-1, and GHBP of children were positively correlated with growth and development indices ( P < 0.001 ). The levels of gastrin, serum IGF-1, and GHBP in children were distinctly improved after treatment ( P < 0.05 ). Conclusion. The gastrin, serum IGF-1, and GHBP are closely related to the SS, and the effective clinical intervention can better improve the above indicators of children to promote their growth and development.

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Section: Discussionmentioning

confidence: 99%

Correlation Study between Levels of Gastrin, Serum IGF-1, and GHBP and Growth and Development in Children with Short Stature Based on Big Data Analysis

Chen

2022

Disease Markers

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“…Liver analyses of vitamin E (a-tocopherol) and vitamin A retinol were performed by high-performance liquid chromatography, according to an adapted method. 28, 29 For the analyses, a Shimadzu chromatograph model LC-20AT was used, with column type C-18 (150 × 4.6 mm -5 µm), UV-visible detector model SPD-20A, a mobile phase composed of 7:2:1 acetonitrile: dichloromethane: methanol, a flow rate of 1.0 mL/min, and detection at 292 nm and 352 nm for α-tocopherol and retinol, respectively. The concentrations were determined by using an external standard, and the results were expressed in µmol/L of serum/plasma.…”

Section: Determination Of Serum Retinol and Serum Vitamin E And Oils ...mentioning

confidence: 99%

Metabolic Effects of Coconut Oil on Fatty Liver and Oxidative Stress Induced by a High-fat Diet in Rats

Barreto¹,

Silva²,

Almeida³

et al. 2023

Gene Expr

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Background and objectives:This study aimed to evaluate the effect of coconut oil (CO) on steatosis and oxidative stress in rats fed a high-fat diet.Methods: Three groups of male Wistar rats were used: the control group (CG, n = 10) received a standard diet for 50 days, the hyperlipidic group (HL, n = 10) received a high-fat diet with 50% lard for 50 days, and the hyperlipidic-CO group (HL+CO, n = 10) received a high-fat diet with 50% lard for 30 days followed by 25% lard and 25% CO for 20 days. Then, the animals were euthanized, and their blood, liver, and adipose tissue were collected for biochemical analyses. Results:The groups that received a high-fat diet had pronounced liver steatosis. Compared to the CG and HL groups, the HL+CO group had less weight gain, but liver fat and triglycerides were increased, with a significant reduction in liver cholesterol. Glutathione increased significantly and vitamin E decreased in the livers of the experimental groups compared to the control. Lipid peroxidation in the serum and liver was less in the HL+CO group compared to that in the HL group, but it was higher than that in the control group. CO caused significant accumulation of hepatic fat, triglycerides, and fat content, despite decreasing the hepatic cholesterol levels. There was a better hepatic antioxidant response in the CO group, especially compared with the HL group. Conclusions:CO was not able to prevent or improve liver fat levels, but the HL+CO group had a better antioxidant profile. Additional clinical studies are necessary to verify the efficacy and safety of different CO doses on both hepatic and lipid metabolism.

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“…VAD, low serum retinol, and low insulin-like growth factor 1 (IGF-1) are thought to contribute to a poor immune system and poor growth and development in children with Down syndrome (DS). A cross-sectional study on 47 children ages 24-72 months with DS revealed a prevalence of VAD of 25.5% (n = 12; 95%CI: 13.9-40.3) [ 14 ]. The relative dose-response test determined VAD results that suggested low vitamin A stores in the liver.…”

Section: Reviewmentioning

confidence: 99%

“…The relative dose-response test determined VAD results that suggested low vitamin A stores in the liver. About 74.5% of children had serum retinol levels <0.70 µmol/L and there was no significant association between VAD and IGF-1 levels, there was a positive correlation between retinol levels and IGF-1 levels [ 14 ].…”

Section: Reviewmentioning

confidence: 99%

Vitamin A-Mediated Birth Defects: A Narrative Review

Abadie,

Staples,

Lauck

et al. 2023

Cureus

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Vitamin A deficiency (VAD) or excess in expectant mothers can result in fetal abnormalities such as night blindness, bone anomalies, or epithelial cell problems. In contrast, excessive vitamin A in pregnancy can precipitate fetal central nervous system deformities. During pregnancy, a pregnant woman should monitor her vitamin A intake ensuring she gets the recommended dosage, but also ensuring she doesn't exceed the recommended dosage, because either one can result in teratogenicity in the fetus. The widespread and unregulated use of multivitamins and supplements makes consuming doses greater than the recommended quantity more common in developed countries. While vitamin A excess is more common in developed countries, deficiency is most prevalent in developing countries. With proper maintenance, regulation, and education about VAD and excess, a pregnant mother can diminish potential harm to her fetus and potential teratogenic risks.

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Vitamin A deficiency and association between serum retinol and IGF-1 concentrations in Brazilian children with Down syndrome

Cited by 4 publications

References 23 publications

Correlation Study between Levels of Gastrin, Serum IGF-1, and GHBP and Growth and Development in Children with Short Stature Based on Big Data Analysis

Correlation Study between Levels of Gastrin, Serum IGF-1, and GHBP and Growth and Development in Children with Short Stature Based on Big Data Analysis

Metabolic Effects of Coconut Oil on Fatty Liver and Oxidative Stress Induced by a High-fat Diet in Rats

Vitamin A-Mediated Birth Defects: A Narrative Review

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