Vascular endothelial growth factor and pulmonary hypertension in children with beta thalassemia major

Alkholy, Usama M.; Mohamed, Soma Abdalla; Elhady, Marwa; Attar, Shahinaz El; Abdalmonem, Nermin; Zaki, Ahmed A.

doi:10.1016/j.jped.2018.05.003

Cited by 6 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar observation was made in the study done by Alkholy et al in which it was found that in pulmonary hypertensive patients, 65.5% were males and 34.5% were females with no significant difference in frequency of pulmonary hypertension between males and females (p value=0.722). 12 In present study, all subjects received multiple transfusions per year (mean±SD=11.71±3.21). The mean Serum ferritin level was 1109.31±412.56 ng/ml, values ranged between 430-2090 ng/ml.…”

Section: Resultsmentioning

confidence: 78%

Prevalence of pulmonary hypertension in pediatric patients with beta-thalassemia major in Central India: a cross sectional study

Gedam

Merchant

2022

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: The objective of the study was to determine the prevalence of pulmonary hypertension in pediatric patients with beta thalassemia major in a tertiary care centre in Central India.Methods: A cross sectional study was conducted in department of pediatrics, Government Medical College and Hospital, Nagpur, India over a period of 2 years. Total 100 subjects of thalassemia major diagnosed by high performance liquid chromatography (HPLC) attending day care in this department were enrolled for study. Measurement of pulmonary pressure was done by using 2D echocardiography with Doppler studies and tricuspid regurgitant jet velocity was measured. This was done by experienced cardiologist. Variables predictive of pulmonary hypertension studied were age, sex, serum ferritin levels, age of onset of chelation therapy, compliance to chelation therapy and number of blood transfusion per year.Results: Out of 100 subjects, 18 subjects had pulmonary hypertension. Univariate analysis proved that age, serum ferritin levels, age of onset of chelation therapy, compliance to chelation therapy and number of blood transfusion per year were significant predictors of pulmonary hypertension. While, multiple logistic regression analysis revealed that only 3 variables that is age of onset of chelation therapy, number of blood transfusion per year and compliance to chelation therapy retained their significance in this patient population.Conclusions: Prevalence of pulmonary hypertension was found out to be 18%. 2 subjects in the pulmonary hypertension group died. High morbidity and mortality of pulmonary hypertension clearly indicates that much work is needed in disease detection and development of more effective therapies. For thalassemic children, early detection and prevention of pulmonary hypertension in childhood would improve survival, reduce morbidity and mortality.

show abstract

Section: Resultsmentioning

confidence: 78%

Prevalence of pulmonary hypertension in pediatric patients with beta-thalassemia major in Central India: a cross sectional study

Gedam

Merchant

2022

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…Alkholy et al have highlighted a notable association between elevated VEGF in PAH patients with high sensitivity and specificity, and serum VEGF levels have a positive link with pulmonary pressure. 5 Furthermore, the cell-based VEGF gene transfer has been demonstrated to be an effective approach for preventing PAH, which is a potential therapeutic tool in the therapy of PAH. 28 In summary, our paper signifies that serum BNP, PTX3, and VEGF are of clinical value as biological indicators for predicting APE-PAH and reflecting the severity of PAH.…”

Section: Discussionmentioning

confidence: 99%

“…APE is able to lead to pulmonary artery hypertension (PAH), induced by macroscopic or microscopic obstruction of the pulmonary vasculatures and active vasoconstriction, because of the released vasoconstrictive mediators and scavenging of nitric oxide by cell‐free hemoglobin 4 . PAH is a multifactorial vascular disorder and caused by the interaction of chronic hemolysis, platelet activation, oxidative stress, dysfunctional angiogenesis, and iron overload 5 . The correct and early increase of pulmonary arterial pressure (PAP) is crucial to decide the proper management and follow‐up for PAH 6 .…”

Section: Introductionmentioning

confidence: 99%

Diagnostic values of serum BNP, PTX3, and VEGF in acute pulmonary embolism complicated by pulmonary artery hypertension and their correlations with severity of pulmonary artery hypertension

Zheng,

Zhang,

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

ObjectiveThis paper aimed to unveil the diagnostic values of serum brain natriuretic peptide (BNP), pentraxin 3 (PTX3), and vascular endothelial growth factor (VEGF) in acute pulmonary embolism complicated by pulmonary artery hypertension (APE‐PAH) and their correlations with severity of PAH.MethodsA total of 153 patients with APE were selected for our study and divided into the PAH and Non‐PAH groups according to the measurement of pulmonary artery pressure by echocardiography. Serum BNP levels were measured by chemiluminescence immunoassay, and serum PTX3 and VEGF levels were appraised by ELISA. The predictive values of BNP, PTX3, and VEGF for APE‐PAH were evaluated by applying the receiver operating characteristic (ROC) curve. Spearman test was implemented to correlate BNP, PTX3, and VEGF with the severity of PAH.ResultsHigher serum levels of BNP, PTX3, and VEGF were observed in the PAH group versus the Non‐PAH group (p < .05). ROC curve analysis indicated that BNP, PTX3, and VEGF had acceptable diagnostic value for predicting APE‐PAH. Higher serum levels of BNP, PTX3, and VEGF were witnessed in the moderate and severe PAH groups in contrast to the mild PAH group (p < .05), and the levels of these parameters were elevated in the severe PAH group versus the moderate PAH group (p < .05). Spearman correlation analysis signified that serum BNP (r = 0.377), PTX3 (r = 0.488), and VEGF (r = 0.575) levels were positively correlated with the severity of PAH in APE‐PAH patients.ConclusionSerum BNP, PTX3, and VEGF levels are significantly elevated in APE‐PAH patients. Serum BNP, PTX3, and VEGF levels are of clinical value in the diagnosis of APE‐PAH patients, and serum BNP, PTX3, and VEGF levels are positively correlated with the severity of PAH and can be used as predictors of the severity of PAH.

show abstract

Section: Hipertensión Pulmonarunclassified

“…La disfunción miocárdica y la insuficiencia cardíaca se consideraron como causas comunes de morbilidad y mortalidad en niños con β-TDT, que se relacionan principalmente con hemólisis crónica y sobrecarga de hierro [52]. Sin embargo, la hipertensión arterial pulmonar (HAP) se ha convertido en un factor de riesgo importante para alteración de la función ventricular derecha en tales pacientes [52]. La HAP es un trastorno vascular complejo y multifactorial, el principal mecanismo subyacente de HAP en pacientes con β-talasemia aún no se conoce; sin embargo, se sugiere que la interacción de varios factores, incluyendo activación plaquetaria, hemólisis crónica, angiogénesis disfuncional, estrés oxidativo y sobrecarga de hierro, están relacionados con la génesis de esta complicación [52].…”

Section: Hipertensión Pulmonarunclassified

Beta-Talasemia: Un mundo de complicaciones con nuevas alternativas de tratamiento.

Alzate

2019

archmed

View full text Add to dashboard Cite

Introducción: β-talasemia, es causada por mutaciones en el gen de la globina HBB, que codifica la subunidad β de la HbA. La enfermedad es conocida por ser altamente prevalente en el área que se extiende desde África subsahariana, a través de la región mediterránea y Medio Oriente. En Colombia, se han reportado varios estudios independientes de hemoglobinopatías en ciudades como Cartagena, Buenaventura, Cali, San Andrés y Providencia debido a su gran población afrodescendiente sobre la cual las Talasemias y otras hemoglobinopatías tienen incidencia directa. Objetivo: recolectar datos acerca de las características clínicas, complicaciones y clasificaciones de β-talasemia con el fin de brindar una fuente de información que permita realizar un diagnóstico eficaz y en consecuencia un tratamiento que busque llegar a la curación completa de los pacientes que sufren esta condición, con el mínimo de complicaciones para los mismos. Conclusión: la β-Talasemia es una hemoglobinopatía estructural que tiene un porcentaje de prevalencia e incidencia importante en el mundo. En Colombia no se tiene claro cuál es la epidemiología real para esta condición puesto que no se han realizado estudios que abarquen una muestra adecuada y significativa. Esta enfermedad genera múltiples complicaciones en diferentes órganos, que no solo están asociadas al desarrollo de la enfermedad, sino también a la terapia de trasfusión a largo plazo. Por esta razón, los nuevos tratamientos están encaminas a lograr en un futuro la curación completa, reduciendo al máximo las complicaciones.

show abstract

Vascular endothelial growth factor and pulmonary hypertension in children with beta thalassemia major

Abstract: Elevated vascular endothelial growth factor serum level is associated with pulmonary artery hypertension in children with β-thalassemia.

Cited by 6 publications

References 26 publications

Prevalence of pulmonary hypertension in pediatric patients with beta-thalassemia major in Central India: a cross sectional study

Prevalence of pulmonary hypertension in pediatric patients with beta-thalassemia major in Central India: a cross sectional study

Diagnostic values of serum BNP, PTX3, and VEGF in acute pulmonary embolism complicated by pulmonary artery hypertension and their correlations with severity of pulmonary artery hypertension

Beta-Talasemia: Un mundo de complicaciones con nuevas alternativas de tratamiento.

Contact Info

Product

Resources

About