Diagnostic values of serum BNP, PTX3, and VEGF in acute pulmonary embolism complicated by pulmonary artery hypertension and their correlations with severity of pulmonary artery hypertension
Qinghou Zheng,
Bin Zhang,
Na Lu
et al.
Abstract:ObjectiveThis paper aimed to unveil the diagnostic values of serum brain natriuretic peptide (BNP), pentraxin 3 (PTX3), and vascular endothelial growth factor (VEGF) in acute pulmonary embolism complicated by pulmonary artery hypertension (APE‐PAH) and their correlations with severity of PAH.MethodsA total of 153 patients with APE were selected for our study and divided into the PAH and Non‐PAH groups according to the measurement of pulmonary artery pressure by echocardiography. Serum BNP levels were measured … Show more
“…Singh et al 21 discovered that in patients undergoing non-cardiac surgery with hypertension and diabetes, preoperative and postoperative serum BNP levels are significantly elevated, making BNP an important predictor for perioperative and postoperative complications, hospital stay, and mortality rates in these patients. Zheng et al 22 found that BNP is significantly overexpressed in the serum of patients with acute pulmonary embolism combined with pulmonary hypertension, and its expression increases with the severity of pulmonary hypertension, having high diagnostic value for the disease, and correlates positively with disease severity, serving as a predictive marker for the severity of the condition. Our study found that the serum levels of BNP in the severe group before and after treatment were significantly higher than those in the mild group; the expression levels in the serum after treatment were significantly lower than before treatment; and the expression levels in the serum of the death group after treatment were significantly higher than those in the survival group, suggesting that BNP reflects cardiac functional changes due to stress in patients and is one of the reasons for worsening conditions, poor therapeutic effect, and poor prognosis in pneumonia patients.…”
To explore the application of serum cardiac troponin T (cTnT), brain natriuretic peptide (BNP) levels, and electrocardiogram changes in the treatment and prognosis evaluation of severe pneumonia in children. Methods: 120 children with severe pneumonia (severe group) admitted to our hospital from June 2020 to December 2022 were selected as the study subjects with prospective study. They were divided into survival group (n=78) and death group (n=42) based on their survival status; 120 children with mild pneumonia were selected as the control group. Compare the levels of serum cTnT and BNP, as well as the changes in electrocardiogram, to analyze their predictive value for the prognosis of pediatric patients and the influencing factors of prognosis. Results: The proportion of children with cTnT, BNP, and abnormal electrocardiogram after treatment was lower than before treatment (P<0.05). The proportion of children with cTnT, BNP, and abnormal electrocardiogram in the severe group was higher than that in the mild group (P<0.05). The proportion of children with serum cTnT, BNP levels, and abnormal electrocardiogram in the death group after treatment was higher than that in the survival group (P<0.05). Bundle branch block, low or inverted T waves, cTnT, and BNP are prognostic factors for children with severe pneumonia (P<0.05). The combined prediction of serum cTnT and BNP for the prognosis of severe pneumonia in children is better than that of single prediction (Z combined detection -cTnT=2.474, Z combined detection -BNP=2.494, P=0.013, 0.013).
Conclusion:The proportion of abnormal cTnT, BNP, and electrocardiogram is increased in patients with severe pneumonia, and those with high expression and abnormalities have poor prognosis. cTnT and BNP have high predictive value for the prognosis of children with severe pneumonia.
“…Singh et al 21 discovered that in patients undergoing non-cardiac surgery with hypertension and diabetes, preoperative and postoperative serum BNP levels are significantly elevated, making BNP an important predictor for perioperative and postoperative complications, hospital stay, and mortality rates in these patients. Zheng et al 22 found that BNP is significantly overexpressed in the serum of patients with acute pulmonary embolism combined with pulmonary hypertension, and its expression increases with the severity of pulmonary hypertension, having high diagnostic value for the disease, and correlates positively with disease severity, serving as a predictive marker for the severity of the condition. Our study found that the serum levels of BNP in the severe group before and after treatment were significantly higher than those in the mild group; the expression levels in the serum after treatment were significantly lower than before treatment; and the expression levels in the serum of the death group after treatment were significantly higher than those in the survival group, suggesting that BNP reflects cardiac functional changes due to stress in patients and is one of the reasons for worsening conditions, poor therapeutic effect, and poor prognosis in pneumonia patients.…”
To explore the application of serum cardiac troponin T (cTnT), brain natriuretic peptide (BNP) levels, and electrocardiogram changes in the treatment and prognosis evaluation of severe pneumonia in children. Methods: 120 children with severe pneumonia (severe group) admitted to our hospital from June 2020 to December 2022 were selected as the study subjects with prospective study. They were divided into survival group (n=78) and death group (n=42) based on their survival status; 120 children with mild pneumonia were selected as the control group. Compare the levels of serum cTnT and BNP, as well as the changes in electrocardiogram, to analyze their predictive value for the prognosis of pediatric patients and the influencing factors of prognosis. Results: The proportion of children with cTnT, BNP, and abnormal electrocardiogram after treatment was lower than before treatment (P<0.05). The proportion of children with cTnT, BNP, and abnormal electrocardiogram in the severe group was higher than that in the mild group (P<0.05). The proportion of children with serum cTnT, BNP levels, and abnormal electrocardiogram in the death group after treatment was higher than that in the survival group (P<0.05). Bundle branch block, low or inverted T waves, cTnT, and BNP are prognostic factors for children with severe pneumonia (P<0.05). The combined prediction of serum cTnT and BNP for the prognosis of severe pneumonia in children is better than that of single prediction (Z combined detection -cTnT=2.474, Z combined detection -BNP=2.494, P=0.013, 0.013).
Conclusion:The proportion of abnormal cTnT, BNP, and electrocardiogram is increased in patients with severe pneumonia, and those with high expression and abnormalities have poor prognosis. cTnT and BNP have high predictive value for the prognosis of children with severe pneumonia.
Identification of accurate biomarkers is still particularly urgent for improving the poor survival of chronic obstructive pulmonary disease (COPD) patients. In this investigation, we aimed to identity the potential biomarkers in COPD via bioinformatics and next generation sequencing (NGS) data analysis. In this investigation, the differentially expressed genes (DEGs) in COPD were identified using NGS dataset (GSE239897) from Gene Expression Omnibus (GEO) database. Subsequently, gene ontology (GO) and pathway enrichment analysis was conducted to evaluate the underlying molecular mechanisms involved in progression of COPD. Protein-protein interaction (PPI), modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network analysis were performed to determine the hub genes, miRNAs and TFs. The receiver operating characteristic (ROC) analysis was performed to determine the diagnostic value of hub genes. A total of 956 overlapping DEGs (478 up regulated and 478 down regulated genes) were identified in the NGS dataset. DEGs were mainly associated with GO functional terms and pathways in cellular response to stimulus. response to stimulus, immune system and neutrophil degranulation. There were 10 hub genes (MYC, LMNA, VCAM1, MAPK6, DDX3X, SHMT2, PHGDH, S100A9, FKBP5 and RPS6KA2) identified by PPI, modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network analysis. In conclusion, the DEGs, relative GO terms, pathways and hub genes identified in the present investigation might aid in understanding of the molecular mechanisms underlying COPD progression and provide potential molecular targets and biomarkers for COPD.
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