Intestinal fructose malabsorption is associated with increased lactulose fermentation in the intestinal lumen

Ozaki, Roberto Koity Fujihara; Speridião, Patrícia da Graça Leite; Soares, Ana Cristina Fontenele; Morais, Mauro Batista de

doi:10.1016/j.jped.2017.08.006

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…In this series, FM was evidenced in 2 out of every 3 patients who underwent the test. This frequency is higher than those previously described by Escobar et al (6) and Hammer et al (8), but similar to that described by Ozaki et al (9) in Brazil. This finding could be explained at least in part because most of the tests were requested by pediatric gastroenterologists from tertiary centers, probably with a high index of suspicion.…”

Section: Discussionsupporting

confidence: 89%

Fructose Malabsorption in Chilean Children Undergoing Fructose Breath Test at a Tertiary Hospital

Alliende

Lucero²,

Jaime³

et al. 2020

J. pediatr. gastroenterol. nutr.

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Fructose is a highly abundant carbohydrate in western diet and may induce bowel symptoms in children as in adults. The main objective of this study is to describe the frequency of fructose malabsorption (FM) in symptomatic patients 18 years or younger undergoing fructose breath test in a single tertiary center between 2013 and 2018, and to evaluate whether certain symptoms are related to positivity of the test. Out of 273 tests 183 (67%) were compatible with FM. The most frequent pretest symptom in the overall study population was bloating (83%), followed by abdominal pain (73%). Patients with positive test were younger than those with a negative test (median 5 vs 8 years, P < 0.001). In multivariate analysis, which included age, sex, and symptoms (diarrhea, abdominal pain, bloating, nausea), only age <6 years (odds ratio 2.93, 95% confidence interval 1.64–5.23) and absence of nausea (odds ratio = 3.32, 95% confidence interval 1.56–7.05) were associated with FM.

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Section: Discussionsupporting

confidence: 89%

Fructose Malabsorption in Chilean Children Undergoing Fructose Breath Test at a Tertiary Hospital

Alliende

Lucero²,

Jaime³

et al. 2020

J. pediatr. gastroenterol. nutr.

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“…Ozaki et al (36) revealed malabsorption of fructose in 67.7% of children aged 4-14 years old with functional abdominal pain, including in 90% of children with IBS included in the study. Children with malabsorption of fructose consumed more carbohydrates and high-energy foods and had higher values of BMI Z-scores.…”

Section: Obesity and Fbds In Children: Possible Mechanisms Of Associamentioning

confidence: 82%

Functional Bowel Disorders and Obesity in Children: State of the Problem

Погодина¹,

Romanitsa²,

Рычкова³

2020

IJBM

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Obesity and functional bowel disorders (FBDs) are often observed in children and have common risk factors. The present review aimed to summarize the published data on the association between obesity and FBDs in children and a discussion of possible pathophysiological mechanisms that may be involved. Published data indicates that obesity and FBDs could be associated conditions. There is substantial evidence that obesity in children is associated with constipation. However, it should be noted that there were few studies in this direction, and those studies were heterogeneous in both the composition of participants and studied diagnostic criteria, and in the majority of cases, they were not adjusted for potential confounders. The association between obesity and FBDs can be explored through diet, peculiarities of eating behavior, and psychological factors. The most promising direction in the study could be the study of the GM, the changes in which can contribute to the development of immune dysfunctions of the bowel, chronic low-grade inflammation, increased colonic permeability, motility disturbances, and visceral hypersensitivity. The studies in this area can provide important data for developing a strategy of treatment and prevention of both groups of diseases.

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“…Test duration of 3 h 65% in healthy patients (n = 20), 70% in IBS patients (n = 30) Skoog et al, 2008 [ 31 ] Fructose (1 g/kg fructose up to maximum of 50 g) Hydrogen Rise of ≥ 20 ppm over baseline hydrogen. Test duration of 3 h (symptoms monitored for 24 h) 68% in patients with abdominal pain (n = 31) Ozaki et al, 2018 [ 32 ] Fructose (A. 50 g fructose in 150 cc water, B.…”

Section: Introductionmentioning

confidence: 99%

Fructose malabsorption and fructan malabsorption are associated in patients with irritable bowel syndrome

Sia,

Tanaka,

Mousad

et al. 2024

BMC Gastroenterol

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Background Food malabsorption and intolerance is implicated in gastrointestinal symptoms among patients with irritable bowel syndrome (IBS). Key triggers include fructose and fructan. Prior studies examined fructose and fructan malabsorption separately in IBS patients. None have concurrently assessed both within the same patient group. We aimed to investigate the association between fructose and fructan malabsorption in the same patients with IBS using hydrogen breath testing (HBT). Methods We retrospectively identified patients with IBS who underwent fructose and fructan HBTs and abstracted their results from the electronic medical record. Fructose and fructan HBTs were performed by administering a 25 g fructose solution or 10 g fructan solution, followed by breath hydrogen readings every 30 min for 3 h. Patients were positive for fructose or fructan malabsorption if breath hydrogen levels exceeded 20 ppm. Results Of 186 IBS patients, 71 (38.2%) were positive for fructose malabsorption and 91 (48.9%) were positive for fructan malabsorption. Of these patients, 42 (22.6%) were positive for fructose malabsorption and fructan malabsorption. Positive fructose HBT readings were significantly associated with positive fructan HBT readings (p = 0.0283). Patients positive for fructose malabsorption or fructan malabsorption had 1.951 times higher odds of testing positive for the other carbohydrate. Conclusions Our results reveal a clinically significant association between fructose malabsorption and fructan malabsorption in patients with IBS. Fructan malabsorption should be assessed in patients with fructose malabsorption, and vice versa. Further studies are required to identify the mechanisms underlying our findings.

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Intestinal fructose malabsorption is associated with increased lactulose fermentation in the intestinal lumen

Abstract: Fructose malabsorption is associated with increased lactulose fermentability in the intestinal lumen. Body mass index was higher in patients with fructose malabsorption.

Cited by 4 publications

References 25 publications

Fructose Malabsorption in Chilean Children Undergoing Fructose Breath Test at a Tertiary Hospital

Fructose Malabsorption in Chilean Children Undergoing Fructose Breath Test at a Tertiary Hospital

Functional Bowel Disorders and Obesity in Children: State of the Problem

Fructose malabsorption and fructan malabsorption are associated in patients with irritable bowel syndrome

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