Health-related quality of life in patients with bronchiolitis obliterans

Sarria, Edgar E.; Mundstock, Eduardo; Machado, Denise Pires; Mocelin, Helena Teresinha; Fischer, Gilberto Bueno; Furlan, Silvana P.; Antonello, Ivan Carlos Ferreira; Stein, Ricardo; Mattiello, Rita

doi:10.1016/j.jped.2017.07.021

Cited by 14 publications

(12 citation statements)

References 13 publications

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“…Our FEV1 and FVC results were concomitant with other studies. 25,29 There were studies that noted lower and higher FEV1/FVC values than our study. 28,[31][32][33] Treatment of PIBO is variable, and there is no standard protocol in the literature.…”

Section: Discussioncontrasting

confidence: 47%

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Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Yazan¹,

Khalif²,

Shadfan³

et al. 2020

Preprint

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Objective: This study aims to evaluate clinical and radiological findings and treatment outcomes of the patients with PIBO. Methods: One hundred fourteen children were enrolled. Initial demographic and clinical findings were evaluated.Pre-and post-treatment symptoms, radiological findings and scores, the number of admissions to the hospital and PICU were compared. Results: Seventy-three patients were male. The median age of the patients at initial pulmonary injury was 7.2 months, the median age at diagnosis was 17.5 months and the median interval from initial injury to diagnosis was 8.5 months. Thirty-five patients had mechanical ventilation history. Persistent wheezing was the most common complaints. The most common radiological findings were peribronchial thickening and air-trapping. Sixty-eight patients were treated with inhaled corticosteroid (IC), systemic corticosteroid (SC) and azithromycin (AZT) combination. 25 patients were treated with only IC, 14 with IC and AZT, and 7 with IC and SC. 82,5% of patients had clinical improvement. Chronic respiratory failure occurred in 11 patients, and three patients died. Bronchiectasis, atelectasis, hyperinflation and air trapping in HRCT improved significantly. Bhalla scores decreased from 8.3 to 6.5 (p= 0,001). IC, SC and AZT combination was effective than the other treatments. Conclusions: This study is one of the largest studies in the literature and one of the few studies that evaluate clinical and radiological outcomes. We found that IC, AZT and SC combination is clinically and radiologically effective in patients with PIBO.

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Section: Discussioncontrasting

confidence: 47%

“…23 In the literature, mechanical ventilation percentages ranged from 23% to 52,5%. 24,25 In our study, 90,3% of patients required hospitalization at least once and one-third of the patients had a history of mechanical ventilation.…”

Section: Discussionmentioning

confidence: 56%

Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Yazan¹,

Khalif²,

Shadfan³

et al. 2020

Preprint

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“…A recent study show that patients with post‐infectious bronchiolitis obliterans present lower health‐ related quality of life scores when compared with healthy individuals and in the health and school domains …”

Section: Clinical Findingsmentioning

confidence: 99%

Post‐infectious bronchiolitis obliterans

Colom

Teper

2018

Pediatric Pulmonology

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Bronchiolitis obliterans is a rare and severe chronic lung disease resulting from a lower respiratory tract lesion. It may occur after a bone marrow or lung transplantation, infectious diseases, or less frequently after inhaling toxic substances or after connective tissue diseases. Pathology, pathogenesis, and molecular biology, as well as the best treatment of bronchiolitis obliterans, remain the subject of ongoing research. This review discusses our current knowledge of different areas of bronchiolitis obliterans associated with infectious lesions. K E Y W O R D S adenovirus, dysinaptic growth, lung development, Mycoplasma, respiratory function tests 212 |

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“…Comorbidades em pacientes com BO são também descritas na literatura ( Kim & Lee, 1996;Callahan et al, 2019), podendo também a própria doença predispor o paciente a comorbidades ou outras doenças induzir BO (Teper et al, 2002;Lin et al, 2018). A promoção de uma melhoria na qualidade de vida dos pacientes com BO deve ser estimulada, visto as complicações da doença bem como as possíveis comorbidades que eles enfrentam (Sarria et al, 2018).…”

Section: Discussionunclassified

Bronquiolite obliterante em paciente pediátrico associada com exposição à cocaína e outras drogas de abuso durante o período gestacional

Moraes

Barboza

Tucci

et al. 2021

RSD

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São ainda escassas as informações na literatura acerca da associação entre exposição da gestante a drogas de abuso, incluindo a cocaína, e o desenvolvimento de bronquiolite obliterante (BO) no neonato. Neste relato de caso abordamos o acompanhamento ao longo dos anos de um paciente pediátrico do sexo masculino que deu entrada como lactente sibilante e, que, após avaliações e observância de critérios clínicos e por imagem sugestivos, foi diagnosticado com BO. Portanto, os achados deste relato fomentam a literatura e lançam uma base acerca de uma relação causal entre exposição da gestante a drogas de abuso e o desenvolvimento de BO no recém-nascido, bem como sobre o perfil epidemiológico, diagnóstico clínico e por imagem e terapêutica (medicamentos e oxigenoterapia) no curso da doença em paciente pediátrico e, suas comorbidades, direcionando também futuras estratégias para o manejo dos pacientes com esta doença.

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Health-related quality of life in patients with bronchiolitis obliterans

Abstract: Patients with post-infectious bronchiolitis obliterans presented lower health-related quality of life scores when compared with healthy individuals in the total score and in the health and school domains.

Cited by 14 publications

References 13 publications

Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Post‐infectious bronchiolitis obliterans

Bronquiolite obliterante em paciente pediátrico associada com exposição à cocaína e outras drogas de abuso durante o período gestacional

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