Trp64Arg polymorphism of the ADRB3 gene associated with maximal fat oxidation and LDL-C levels in non-obese adolescents

Jesus, Íncare Correa de; Alle, Lupe Furtado; Munhoz, Eva Cantalejo; Silva, Larissa Rosa da; Lopes, Wendell Arthur; Tureck, Luciane Viater; Titski, Ana Cláudia Kapp; Leite, Neiva

doi:10.1016/j.jped.2017.07.010

Cited by 10 publications

(5 citation statements)

References 22 publications

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“…A correlation between Trp64Arg and type 2 diabetes, likely dependent on ethnicity, has been described in a recent meta-analysis [187]. The presence of Trp64Arg was also reported to influence metabolic parameters such as LDL-C [10] and HDL-C [11] accumulation rates and resistance to weight loss in cohorts of Brazilian and Japanese patients, respectively. Consistently, Trp64 polymorphism correlates with increases in Body Mass Index [188] and has a weak but significant influence on carriers leading to greater fat mass and percentage [189].…”

Section: Polymorphismsmentioning

confidence: 99%

“…Given β 3 -AR expression and signaling in districts such as myocardium and adipose tissue, mirabegron is also being tested in repurposing trials for cardiovascular and metabolic conditions (commented on in [8,9]). Consistently, β 3 -AR’s most common genetic variant, Trp64Arg, has been found to positively correlate with metabolic parameters such as HDL-C (High Density Lipoprotein-Cholesterol) and LDL-C (Low Density Lipoprotein-Cholesterol) accumulation rates and glucose tolerance [10,11]. After a brief overview of basic information regarding gene structure, protein, and pharmacology of the receptor, we will focus on β 3 -AR role in some of the main tissues where its expression has been reported.…”

Section: Introductionmentioning

confidence: 97%

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Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)

Schena

Caplan

2019

Cells

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The beta-3 adrenergic receptor (β3-AR) is by far the least studied isotype of the beta-adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal and cellular models and inter-species differences, a substantial body of literature on the subject has built up in the last three decades and the physiology of β3-AR is unraveling quickly. As will become evident in this work, β3-AR is emerging as an appealing target for novel pharmacological approaches in several clinical areas involving metabolic, cardiovascular, urinary, and ocular disease. In this review, we will discuss the most recent advances regarding β3-AR signaling and function and summarize how these findings translate, or may do so, into current clinical practice highlighting β3-AR’s great potential as a novel therapeutic target in a wide range of human conditions.

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Section: Polymorphismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)

Schena

Caplan

2019

Cells

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“…Most studies report a fatmax between 40% to 50% of VO 2 max in obese subjects; however, there are large intra-individual variations, independent of sex (30-65% of VO 2 max) [6,7]. Such variations are related to differences in CRF, body composition, and genotype [17,18], indicating that at moderate exercise intensity, some individuals will be working within the fatmax zone, while others are below or above, resulting in different fat oxidation rates among individuals. For these arguments, moderate exercise training should not be considered as fatmax training, as exercise at maximal fat oxidation (MFO) requires individual testing and prescription.…”

Section: Introductionmentioning

confidence: 99%

Chronic Effect of Fatmax Training on Body Weight, Fat Mass, and Cardiorespiratory Fitness in Obese Subjects: A Meta-Analysis of Randomized Clinical Trials

Chávez-Guevara

Urquídez-Romero

Pérez-León

et al. 2020

IJERPH

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Exercise training performed at the maximal fat oxidation intensity (FMT) stands out as a potential treatment of overweight and obesity. This work is a meta-analysis of randomized clinical trials of studies about the effect of FMT on fat mass and maximal oxygen consumption using PubMed, SCOPUS, EBSCOhost, and ScienceDirect as databases. Two independent reviewers selected 11 trials from 356 publications identified by the following keywords: fatmax, lipoxmax, maximal fat oxidation, peak of fat oxidation, physical training, physical exercise, body fat (BF), fat mass, overweight, and obesity. The risk of bias was assessed following the Cochrane Guidelines. The pooled mean difference was computed for each outcome with the random-effects model and the inverse-variance method. The meta-analysis was performed with the RevMan software v 5.3, and the heterogeneity across studies by the I2. The statistical significance was accepted at p < 0.05. Results showed that the FMT reduced body weight (MD = −4.30 kg, p < 0.01, I2 = 0%), fat mass (MD = −4.03 kg, p < 0.01, I2 = 0%), and waist circumference (MD = −3.34 cm, p < 0.01). Fat-free mass remains unchanged (MD = 0.08 kg, p = 0.85), but maximal oxygen consumption increased (MD = 2.96 mL∙kg−1∙min−1, p < 0.01, I2 = 0%). We conclude that FMT at short and medium-term (eight to twenty weeks) reduces body weight and BF, increasing cardiovascular fitness in low physical fitness people with obesity.

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“…If the relationship between IR and Trp64Arg mutation can be attributed to obesity, we should pay attention to the underlying mechanism. The Trp64Arg variant has been shown to reduce lipolysis (47). Another study found that the Trp64Arg mutation can influence body weight loss (48).…”

Section: Discussionmentioning

confidence: 99%

The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis

Wang

Zhang

et al. 2021

Front. Endocrinol.

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BackgroundInsulin resistance is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) may be involved in IR and insulin secretion. However, their association is controversial. Therefore, the current meta-analysis was conducted to clarify the relationship between the Trp64Arg and IR.MethodsThe literature search was performed in PubMed, Embase, and Web of Science using the keywords “Receptors, Adrenergic, beta-3, Receptors, Adrenergic, Insulin Resistance, Protein-Coupled Receptor Kinase 3” from 2005 to February 7, 2021. We used a random-effects model to calculate the pooled effect size. We conducted subgroup analysis and regression analysis to identify sources of heterogeneity; and Egger’s test and funnel plot were used to test publication bias. Finally, we conducted a sensitivity analysis.ResultsWe included eight papers with 1,586 subjects. There was a positive correlation between Trp64Arg mutation and insulin level (standardized mean difference = 0.20, 95% confidence intervals: 0.00 to 0.39, I2 = 57.6%, p = 0.016). However, there was no association between Trp64Arg and the homeostasis model (HOMA-IR) assessment. Egger’s tests showed no publication bias; the sensitivity analysis showed that our results were stable. Regression analysis revealed no source of heterogeneity.ConclusionTrp64Arg may be associated with IR. European ancestry, obesity, plasma insulin level, and test status may be potential factors affecting the relationship between Trp64Arg and IR.

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Trp64Arg polymorphism of the ADRB3 gene associated with maximal fat oxidation and LDL-C levels in non-obese adolescents

Abstract: Although the physiological processes related to lipolysis and lipid metabolism are complex, the presence of the Arg 64 allele was associated with lower rates of FATMAX during aerobic exercise, as well as with higher levels of LDL-c in adolescents.

Cited by 10 publications

References 22 publications

Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)

Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)

Chronic Effect of Fatmax Training on Body Weight, Fat Mass, and Cardiorespiratory Fitness in Obese Subjects: A Meta-Analysis of Randomized Clinical Trials

The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis

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