High frequency of methicillin-susceptible and methicillin-resistant Staphylococcus aureus in children under 1 year old with skin and soft tissue infections

Salazar-Ospina, Lorena; Jiménez, J. Natalia

doi:10.1016/j.jped.2017.06.020

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…In our study 40% of patients were less than 1 year of age which was comparable with the study by Salazar (41.2%) 3 and Wang et al (42%). 10 This finding shows that CA-MRSA causes more invasive infections in younger age groups and is amongst the leading cause of skin and subcutaneous tissue infections in this population.…”

Section: Resultssupporting

confidence: 92%

“…Similar findings were reported by Salazar et al 3 This could be due to the immature immune system in this age group which allows easy colonization by the organism and rapid spread of infection.…”

Section: Resultssupporting

confidence: 90%

“…Several studies have shown that MRSA infections of otherwise healthy patients in the community are on the increase, with a reported incidence ranging from 33% to 69%. 3 Soft tissue infections due to Community-acquired MRSA (CA-MRSA) are becoming increasingly prevalent in the pediatric population even in western population. 4 Data from 43 children's hospitals represented in the Pediatric Health Information System was analyzed by, Gerber et al and they reported an increase in MRSA soft tissue infections from 0.2% of admissions in 2002 to 1.1% of admissions in 2007.…”

Section: Introductionmentioning

confidence: 99%

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Community Acquired Methicillin Resistant Staphylococcus Aureus (CA-MRSA) Infection in Paediatric Subcutaneous Abscesses in Pakistan

Sheikh

2021

Proceedings S.Z.M.C

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Introduction: Staphylococcus aureus is one of the common pathogens of the human body. Previously a change in its sensitivity pattern was observed in which it became methicillin resistant but this strain was usually seen in hospital settings or in immunocompromised patients. Recently a changing trend has been observed in which a new variant of methicillin resistant staphylococcus aureus (MRSA) is being isolated specially in pediatric patients, who do not have any risk factors. This strain is labeled as community acquired MRSA. Aims & Objectives: To find the frequency of Community Acquired Methicillin-resistant Staphylococcus Aureus (CAMRSA) in paediatric sub-cutaneous abscesses. Place and duration of study: A cross-sectional prospective study was conducted in Department of Paediatric Surgery Shaikh Zayed Medical Complex, Lahore from January 2017 till December 2020. Material & Methods: All the patients from 7 days to 14 years of age from both genders having subcutaneous abscesses were included. Neonates having hospital stay of more than 24 hours at birth were excluded. Patients having abscess secondary to any surgical intervention, recent hospitalization or trauma were also excluded. Patients were divided into four groups based on age. Pus samples were taken for culture & sensitivity. Data analysis was performed using SPSS version 20. Results: There were 143 patients and 75 (52.4%) of them were males. Patient were divided in groups on the basis of age. The most common location of abscess was head & neck (43.4%) followed by lower limbs and buttocks (30.1%). The most common organism to grow was Staph. aureus (75%) and out of these 107 cases 70 (65.4%) had MRSA. No growth was obtained in 30 (21%) patients. Other less common organisms were seen in 6 (4%) cases. In less than 1 month of age of patients 76% had MRSA which was significantly higher than in other age groups (pvalue 0.047). Conclusion: The frequency of CA-MRSA in paediatric subcutaneous abscesses is on the rise across the globe and more cases of invasive infections are being reported. So, population-based studies are required to assess the prevalence of this bacteria amongst paediatric population of Pakistan.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Community Acquired Methicillin Resistant Staphylococcus Aureus (CA-MRSA) Infection in Paediatric Subcutaneous Abscesses in Pakistan

Sheikh

2021

Proceedings S.Z.M.C

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“…In this study, most MRSA isolates were susceptible to vancomycin and linezolid, which is consistent with previous studies in China, Japan, and Colombia. 12 , 30 , 33 These findings suggest that vancomycin and linezolid are still used as the first-line antibiotic treatment for MRSA infections. Notably, MDRSA infections are associated with worse health outcomes and higher expenditures.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and Molecular Characteristics of Community-Associated Staphylococcus aureus Infection in Neonates

Dong¹,

Liu²,

Li³

et al. 2020

IDR

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Background Staphylococcus aureus is an important human pathogen causing a wide variety of diseases ranging from mild skin infections to life-threatening bacteremia. This study aimed to provide insight into the phenotype–genotype characteristics of S. aureus isolated from neonates. Methods A hospital-based retrospective study was conducted to recruit neonatal patients with community-associated S. aureus infection. All 92 S. aureus clinical isolates were tested for antimicrobial susceptibility, resistance genes, virulence genes, and multilocus sequence typing. Results A total of 92 S. aureus isolates were included in this study, including 29 (31.5%) MRSA isolates. Most S. aureus isolates were susceptible to gentamicin, and most methicillin-resistant S. aureus (MRSA) isolates were susceptible to vancomycin and linezolid. The predominant S. aureus genotypes were CC188 (ST188), CC59 (ST338), CC5 (ST5), CC88 (ST8), and CC6 (ST6), with CC59 (ST338) as the most prevalent MRSA. We observed a significantly corresponding relationship between clonal complexes and resistance patterns (such as CC45/CC59/CC121/CC630 associated with multidrug resistance) or the number of virulence genes (such as CC1/CC5/CC45/CC59/CC88 associated with harboring 5–7 virulence genes, and CC22/CC25/CC121 associated with carrying 8–13 genes). Moreover, both univariate and multivariate analyses indicated that invasive S. aureus isolates were significantly associated with resistance to several classes of antibiotics and carrying specific virulence factors. Conclusion Our ﬁndings provide insight into phenotype–genotype characteristics for S. aureus isolates so as to provide new ideas for differentiating potential genetic backgrounds and monitoring new epidemiologic trends.

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“…Sources of isolation included wound (25; 33.4%), abscess (16; 21.3%), respiratory tract secretions (11; 14.7%), urine (10; 13.3%), blood (6; 8%), conjunctivitis (4; 5.3%), and body fluids (3; 4%). Healthcare–associated MSSA (HA‐MSSA) infection was defined if the positive culture of MSSA was obtained on or after the third day of admission to a hospital 21 . The Ethics Committee of the Shahid Beheshti University of Medical Sciences in Tehran, Iran approved this research (IR.…”

Section: Methodsmentioning

confidence: 99%

Genetic analysis of methicillin‐susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug‐resistant ST239 with strong biofilm‐production ability

Goudarzi

Sabzehali

et al. 2020

Clinical Laboratory Analysis

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High frequency of methicillin-susceptible and methicillin-resistant Staphylococcus aureus in children under 1 year old with skin and soft tissue infections

Abstract: In contrast with other locations, a prevalence of infections in children under 1 year of age in the city could be observed; this emphasizes the importance of epidemiological knowledge at the local level.

Cited by 8 publications

References 25 publications

Community Acquired Methicillin Resistant Staphylococcus Aureus (CA-MRSA) Infection in Paediatric Subcutaneous Abscesses in Pakistan

Community Acquired Methicillin Resistant Staphylococcus Aureus (CA-MRSA) Infection in Paediatric Subcutaneous Abscesses in Pakistan

Phenotypic and Molecular Characteristics of Community-Associated Staphylococcus aureus Infection in Neonates

Genetic analysis of methicillin‐susceptible Staphylococcus aureus clinical isolates: High prevalence of multidrug‐resistant ST239 with strong biofilm‐production ability

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