Erythrocyte oxidative stress markers in children with sickle cell disease

Abstract

Oxidative stress parameters in children's erythrocytes were determined using simple laboratory methods with small volumes of blood; these biomarkers can be useful to evaluate disease progression and outcomes in patients.

Pyrethroid Insecticide Effect on Platelet Biomembranes of Rats

“…If demyelinization occurs, nerve impulses are either slowed (sometimes to the point of halting), or they misfire because there is no conductor to give them direction. The observed increase in lipid peroxidation in tetramethrin-and prallethrin-exposed subjects when compared to controls corroboratest he reports of others [42][43]. Data presented in Table 2 reveal the inhibition of ATPases, the enzymes associated with the platelet membrane, like ATPases and nucleotidases, are essential for the membrane-related functions like adhesion, aggregation and secretion of granules.…”

Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion

“…In addition, although there was a statistically significant decrease in the PTR for G6PD-deficient RBCs, this study was performed in healthy volunteers. Thus, it remains unknown if this PTR difference would be greater in transfused patients, such as those with sickle cell disease, who experience increased oxidative stress at baseline (58). For example, chronically transfused pediatric patients with sickle cell disease have poorer suppression of reticulocytosis and higher hemoglobin S levels between transfusion episodes when receiving G6PD-deficient donor RBCs (28).…”

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“…Erythrocyte volume control is essential for its proper function and, therefore, for life: Overhydration or hypohydration are common fate of diseases involving primarily erythrocytes as seen in plasmodium infection, alcohol intoxication, sickle cell disease, hereditary spherocytosis and thalassemia [18][19][20][21]. Considering this, although lack of organelles and nuclei, erythrocytes access sophisticated ways to control ion flux.…”