Pyrethroid Insecticide Effect on Platelet
Biomembranes of Rats

Li, Qiu-Huan; Liu, Xiaoyu; Maddu, Narendra; Zhao, Chen

doi:10.15244/pjoes/102780

Cited by 1 publication

(3 citation statements)

References 14 publications

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“…25 In addition, Li and coauthors revealed that the tetramethrin-triggered membrane fluidity decrease, lipid peroxidation, and phospholipid reduction would severely affect the secretory function of the platelet cells. 46 Therefore, the damaged integrity, increased permeability, depolarization, and weakened fluidity of the M. barkeri cytomembrane under ammonia pressure may be responsible for the methanogenesis decrease, inviability, and even death of M. barkeri (data shown in Figures 1A,B, and S8A). Beyond this, the significant leakage of the cytoplasmic DNA in the M. barkeri belonging to the TAN2100 group (Figure S8B) suggested the noxious results of cytomembrane damage upon high ammonia exposure.…”

Section: ■ Results and Discussionsupporting

confidence: 88%

“…Previous research studies have pointed out that membrane damage was the vital reason for cell dysfunction and death. ,, For example, Roy et al found that over 60% of cell death of Gram-positive Staphylococcus aureus occurred under the obvious depolarization and damaged the integrity of the cytomembrane along with the extensive extraction of phospholipid molecules triggered by chitosan-exfoliated MoS 2 nanosheets . Treatment with diphenylalanine nanoassemblies for 1 h induced a distinct depolarization and enlarged permeability of the membrane, causing significant cell death of Gram-negative Escherichia coli .…”

Section: Resultsmentioning

confidence: 99%

“…Treatment with diphenylalanine nanoassemblies for 1 h induced a distinct depolarization and enlarged permeability of the membrane, causing significant cell death of Gram-negative Escherichia coli . In addition, Li and co-authors revealed that the tetramethrin-triggered membrane fluidity decrease, lipid peroxidation, and phospholipid reduction would severely affect the secretory function of the platelet cells . Therefore, the damaged integrity, increased permeability, depolarization, and weakened fluidity of the M.…”

Section: Resultsmentioning

confidence: 99%

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Physiological Responses of Methanosarcina barkeri under Ammonia Stress at the Molecular Level: The Unignorable Lipid Reprogramming

Liu

Zhang

Chen

et al. 2023

Environ. Sci. Technol.

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Acetotrophic methanogens' dysfunction in anaerobic digestion under ammonia pressure has been widely concerned. Lipids, the main cytomembrane structural biomolecules, normally play indispensable roles in guaranteeing cell functionality. However, no studies explored the effects of high ammonia on acetotrophic methanogens' lipids. Here, a high-throughput lipidomic interrogation deciphered lipid reprogramming in representative acetoclastic methanogen (Methanosarcina barkeri) upon high ammonia exposure. The results showed that high ammonia conspicuously reduced polyunsaturated lipids and longerchain lipids, while accumulating lipids with shorter chains and/or more saturation. Also, the correlation network analysis visualized some sphingolipids as the most active participant in lipid−lipid communications, implying that the ammonia-induced enrichment in these sphingolipids triggered other lipid changes. In addition, we discovered the decreased integrity, elevated permeability, depolarization, and diminished fluidity of lipid-supported membranes under ammonia restraint, verifying the noxious ramifications of lipid abnormalities. Additional analysis revealed that high ammonia destabilized the structure of extracellular polymeric substances (EPSs) capable of protecting lipids, e.g., declining α-helix/(β-sheet + random coil) and 3-turn helix ratios. Furthermore, the abiotic impairment of critical EPS bonds, including C−OH, C�O−NH−, and S−S, and the biotic downregulation of functional proteins involved in transcription, translation, and EPS building blocks' supply were unraveled under ammonia stress and implied as the crucial mechanisms for EPS reshaping.

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Section: ■ Results and Discussionsupporting

confidence: 88%