Effect of 4′galactooligosaccharide on constipation symptoms

Beleli, Célia A.V.; Antônio, Maria Ângela R. G. M.; Santos, R. dos; Pastore, Gláucia Maria; Lomazi, Elizete Aparecida

doi:10.1016/j.jped.2015.01.010

Cited by 18 publications

(19 citation statements)

References 28 publications

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“…In a randomized trial, the effects of GOS ingestion were tested in pediatric patients (4-16 years of age) with chronic constipation. This study demonstrated that administration of 1.7 gram of GOS per day increased bowel movement frequency, relieved straining during defecation, and decreased stool consistency in comparison with the placebo group receiving maltodextrin (Beleli, Antonio, dos Santos, Pastore, & Lomazi, 2015).…”

Section: Effect Of Prebiotics On Microbiotamentioning

confidence: 69%

Interplay between food and gut microbiota in health and disease

Danneskiold‐Samsøe

Barros

Santos

et al. 2019

Food Research International

194

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Section: Effect Of Prebiotics On Microbiotamentioning

confidence: 69%

Interplay between food and gut microbiota in health and disease

Danneskiold‐Samsøe

Barros

Santos

et al. 2019

Food Research International

194

View full text Add to dashboard Cite

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“…Oligosaccharides are a non-digestible complex carbohydrate source [ 45 ] that increases fecal weight and water in the stools [ 46 ]. Galactooligosaccharides (FOS) exemplify this type of soluble dietary fiber [ 39 ]. One study evaluated the effect of oligosaccharides on stool consistency in the pediatric population [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…Galactooligosaccharides (FOS) exemplify this type of soluble dietary fiber [ 39 ]. One study evaluated the effect of oligosaccharides on stool consistency in the pediatric population [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children

Axelrod

Saps

2018

Nutrients

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We reviewed the available evidence on the role of fiber in the treatment of Functional Constipation (FC) and Irritable Bowel Syndrome (IBS) in children. The vast majority of toddlers and preschoolers do not consume enough fiber. Two of the most common reasons for consultation to a pediatric gastroenterology practice include FC and IBS. The North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) guidelines state that the evidence does not support the use of fiber supplements in the treatment of FC in children, and the Rome IV criteria do not recommend an increase in fiber consumption, in children with IBS. Despite this, in general practice, it is commonly recommended that children who experience constipation and IBS to increase their fiber intake. We conducted a systematic review of the available evidence on the role of fiber in the treatment of FC and IBS in children. Thirteen full-text articles with a total of seven hundred and twenty-three pediatric participants were included in this review. Three clinical trials found positive effects of dietary fiber for the management of IBS. Nine out of ten trials found fiber to be either more effective than placebo, or just as effective as laxative treatment. Most studies on the use of fiber for the treatment of FC and IBS have shown its benefit. However, due to the heterogeneity in study design, length of treatment, outcome measures, and amount and type of fiber, we were unable to make a definitive recommendation supporting the use of fiber for the treatment of FC and IBS in children.

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“…It was reported that at the end of the fourth week, defecation frequencies were 0.92 ± 0.72 and 0.75 ± 0.61 in the lactulose with Lactobacillus group and lactulose group, respectively; stool consistencies were 0.46 ± 0.51 and 0.42 ± 0.50 in the lactulose with Lactobacillus group and lactulose group, respectively. Beleli et al [ 209 ] performed an interventional, non-randomized, double-blinded, placebo-controlled, crossover study with 20 children and adolescents (age 4–16 years) to evaluate the effectiveness of galacto-oligosaccharide vs. maltodextrin for the treatment of constipation. Finally, a total of 20 subjects finished the study protocol.…”

Section: Gut Healthmentioning

confidence: 99%

Biological Activities of Lactose-Derived Prebiotics and Symbiotic with Probiotics on Gastrointestinal System

et al. 2018

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Lactose-derived prebiotics provide wide ranges of gastrointestinal comforts. In this review article, the probable biochemical mechanisms through which lactose-derived prebiotics offer positive gastrointestinal health are reported along with the up-to-date results of clinical investigations; this might be the first review article of its kind, to the best of our knowledge. Lactose-derived prebiotics have unique biological and functional values, and they are confirmed as ‘safe’ by the Food and Drug Administration federal agency. Medical practitioners frequently recommend them as therapeutics as a pure form or combined with dairy-based products (yoghurt, milk and infant formulas) or fruit juices. The biological activities of lactose-derived prebiotics are expressed in the presence of gut microflora, mainly probiotics (Lactobacillus spp. in the small intestine and Bifidobacterium spp. in the large intestine). Clinical investigations reveal that galacto-oligosaccharide reduces the risks of several types of diarrhea (traveler’s diarrhea, osmotic diarrhea and Clostridium difficile associated relapsing diarrhea). Lactulose and lactosucrose prevent inflammatory bowel diseases (Crohn’s disease and ulcerative colitis). Lactulose and lactitol reduce the risk of hepatic encephalopathy. Furthermore, lactulose, galacto-oligosaccharide and lactitol prevent constipation in individuals of all ages. It is expected that the present review article will receive great attention from medical practitioners and food technologists.

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Effect of 4′galactooligosaccharide on constipation symptoms

Abstract: Galactooligosaccharide was effective at improving clinical symptoms in this group of constipated children.

Cited by 18 publications

References 28 publications

Interplay between food and gut microbiota in health and disease

Interplay between food and gut microbiota in health and disease

The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children

Biological Activities of Lactose-Derived Prebiotics and Symbiotic with Probiotics on Gastrointestinal System

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