Newborn screening for sickle cell disease: necessary but not sufficient

Wang, Winfred C.

doi:10.1016/j.jped.2015.01.002

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…In this study, the differences in mean ages between groups may be explained by the fact that the carriers of these two serious diseases (sickle cell anemia and homozygous beta-thalassemia) are referred to treatment centers very early in their lives [11, 12, 27, 29, 33–35]. Thus, the samples are from young patients who are under treatment and consequently these two groups had lower mean ages compared to the group of patients with heterozygous beta-thalassemia.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Toxoplasma gondii antibodies in patients with beta-hemoglobinopathies: the first report in the Americas

et al. 2017

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BackgroundIn Brazil, there have been no previous studies of Toxoplasma gondii infection in sickle cell anemia patients and carriers of severe forms of beta-thalassemia. This study evaluated T. gondii infection in patients with beta-hemoglobinopathies.MethodsA total of 158 samples, 77 (48.7%) men and 81 (51.3%) women, were evaluated. Three groups were formed: G1 (85 patients with sickle cell disease); G2 (11 patients with homozygous beta-thalassemia; G3 (62 patients with heterozygous beta-thalassemia). ELISA was employed to identify anti-T. gondii IgM and IgG antibodies, and molecular analysis was performed to determine beta-hemoglobin mutations. Fisher’s exact test was used to compare frequencies of anti-T. gondii IgM and IgG antibodies in respect to gender and age.ResultsAnti-T. gondii IgG antibodies were found in 43.5% of individuals in G1, 18.1% in G2 and 50% in G3. All samples from G1 and G2 were seronegative for anti-T. gondii IgM antibodies, but 3.2% from G3 were seropositive. Considering anti-T. gondii IgG antibodies, no statistical significant differences were found between these groups nor in seroprevalence between genders within each group. Despite this, comparisons of the mean ages between G1, G2 and G3 were statistically significant (G2 vs. G1: p value = 0.0001; G3 vs. G1: p-value <0.0001; G3 vs. G2: p-value = 0.0001).ConclusionA comparison by age of patients with sickle cell anemia showed a trend of lower risk of infection among younger individuals. Therefore, this study demonstrates that T. gondii infection occurs in patients with beta-thalassemia and sickle cell anemia in Brazil as seen by the presence of anti-T. gondii IgM and IgG antibodies.

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Section: Discussionmentioning

confidence: 99%

“…In fact, cases of malaria and Chagas disease have been identified after blood transfusions [7–10]. Infections, mainly septicemia and pneumonia, account for 45% of deaths in sickle cell disease children, even though these infections are not necessarily acquired by transfusions [11, 12]. …”

Section: Introductionmentioning

confidence: 99%

Anti-Toxoplasma gondii antibodies in patients with beta-hemoglobinopathies: the first report in the Americas

et al. 2017

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“…A ocorrência de STA e de internações por mais de três vezes está relacionada com maior gravidade da DF, sendo uma das principais causas de morte em crianças com a doença. 9 Nossos resultados reforçam a necessidade de promover cuidados preventivos para minimizar as manifestações clínicas na doença falciforme nas visitas de rotina aos centros de saúde.…”

Section: Resultsunclassified

Condições clínicas, nutricionais e sociais de crianças com doença falciforme acompanhadas em um centro de referência: estudo descritivo

Santos

Damião²,

Freitas

et al. 2020

DEMETRA

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Objetivo: Descrever as características clínicas, sociais e nutricionais de crianças com doença falciforme de 5-9 anos. Método: Trata-se de estudo seccional em amostra aleatória de 190 crianças avaliada entre 2015 e 2016, cadastradas em um hospital de referência em hematologia do Rio de Janeiro, Brasil. Resultados: A maioria das crianças estudadas possuía o genótipo Hb SS (65,3%), teve seu diagnóstico na triagem neonatal (91%) e iniciou o acompanhamento médico antes dos seis meses de idade (91,5%). Excesso de peso e baixa estatura foram encontrados em 14,2% e 6,2% das crianças, respectivamente. Em relação às condições sociais da família, a maioria dos pais possuíam companheiros (60,5%), viviam com até meio salário mínimo (55,8%) e as mulheres deixaram seus empregos para acompanhar o tratamento da criança (52,4%). Conclusão: As crianças com doença falciforme foram diagnosticadas precocemente, aproximadamente um sexto delas estavam em excesso de peso e 20% declararam renda de até um quarto de salário mínimo. O fortalecimento da rede de atenção no SUS às pessoas com DF é uma importante medida para mitigar os problemas identificados neste estudo.

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RETRACTED: Gene frequency reports of sickle cell trait among six human populations of Jammu and Kashmir, India

et al. 2016

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Newborn screening for sickle cell disease: necessary but not sufficient

Cited by 7 publications

References 15 publications

Anti-Toxoplasma gondii antibodies in patients with beta-hemoglobinopathies: the first report in the Americas

Anti-Toxoplasma gondii antibodies in patients with beta-hemoglobinopathies: the first report in the Americas

Condições clínicas, nutricionais e sociais de crianças com doença falciforme acompanhadas em um centro de referência: estudo descritivo

RETRACTED: Gene frequency reports of sickle cell trait among six human populations of Jammu and Kashmir, India

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