Growth retardation and metabolic programming: implications and consequences for adult health and disease risk

Hoffman, Daniël J.

doi:10.1016/j.jped.2014.04.005

Cited by 15 publications

(15 citation statements)

References 24 publications

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“…Children with GHD are identified when they do not respond to two GH stimulation tests, and despite all of the controversies involving the need for these GH tests 25 , 26 , the tests still provide important data for differential diagnosis relative to other conditions that can present a clinical context similar to that of isolated or idiopathic GHD 2 , 3 .…”

Section: Discussionmentioning

confidence: 99%

“…After birth, growth in height results from endogenous factors, such as hormones and genetic background, and from exogenous factors, such as proper nutrition and the psychosocial and emotional conditions under which the individual develops 1 , 2 .…”

Section: Introductionmentioning

confidence: 99%

“…It has been arbitrarily agreed that the plasma-stimulated GH level (the GH peak) that is indicative of adequate secretion is ≥10 ng/mL, as assayed by radioimmunoassay (RIA) 6-11 . Below this cut-off, individuals are considered as GH deficient within the appropriate clinical context 2 , 3 .…”

Section: Introductionmentioning

confidence: 99%

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Clonidine-stimulated growth hormone concentrations (cut-off values) measured by immunochemiluminescent assay (ICMA) in children and adolescents with short stature

Borges¹,

Teixeira²,

Feltrin³

et al. 2016

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OBJECTIVES:To establish cut-off values for growth hormone concentrations using clonidine as a secretagogue and an immunochemiluminescent assay as the method of measurement and to analyze the response time as well as the influence of gender, nutritional status and pubertal stage.METHODS:A total of 225 tests were performed in 3 patient groups, categorized as group 1 (normal), group 2 (idiopathic short stature) and group 3 (growth hormone deficiency). Among the 199 disease-free individuals, 138 were prepubertal, and 61 were pubertal. Clonidine (0.1 mg/m2) was orally administered, and the growth hormone level was measured by immunochemiluminescent assay. The growth hormone peak and the difference between the growth hormone peak and the baseline level were then analyzed. Statistical analyses were performed using Student's t-test or the Mann-Whitney test and Kruskal-Wallis test followed by Dunn's post hoc test. Cut-off values were determined using a receiver operating characteristic curve.RESULTS:Group 1 and group 2 had no difference in growth hormone peak, gender, body mass index standard deviation score, or pubertal stage. Group 3 exhibited a significantly lower growth hormone peak than the other groups did. The receiver operating characteristic curve demonstrated that growth hormone concentrations ≥ 3.0 ng/mL defined responsiveness to clonidine. In total, 3.02% of individuals in group 1 and group 2 were considered false positive, i.e., these children lacked growth hormone deficiency and had a peak below 3.0 ng/mL.CONCLUSION:Clonidine-stimulated growth hormone concentrations ≥3 ng/mL, as measured by immunochemiluminescent assay, suggest responsiveness to the stimulus regardless of gender, body mass index standard deviation score or pubertal stage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clonidine-stimulated growth hormone concentrations (cut-off values) measured by immunochemiluminescent assay (ICMA) in children and adolescents with short stature

Borges¹,

Teixeira²,

Feltrin³

et al. 2016

Clinics

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“…The number of longitudinal studies for the association between Low Birth Weight (LBW) and the dynamic of physical growth and body composition during the children's first school years (7-10 years old) is scarce. This can be due to the difficulties related to longitudinal research, such as changes in sample sizes across data collection and changes in covariates throughout children's growth [7,9,12]. These aspects, in association with other factors related to logistical and financial conditions, can limit the number of longitudinal studies with school age children, specially in the Brazilian Northeast region.…”

Section: Introductionmentioning

confidence: 99%

Birth weight, physical growth and body composition in children: A longitudinal study

et al. 2018

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Objective To describe children’s physical growth (body mass and height) velocity and body composition (fat percentage and Fat Free Mass); to investigate the magnitude of interindividual differences according to age, gender and birth weight categories, as well as to examine the differences in the average trajectories of children with Low Birth Weight and Normal Weight according to international references. Methods The sample consisted of 534 children (279 boys and 255 girls, 7 to 10 years old) evaluated in the first year of study and followed for 3 years with overlap between the ages of 7 and 9 years. Physical growth and body composition measurements included: height, body mass, fat percentage (%Fat) and Fat Free Mass. Multilevel Modelling was used. Results Birth weight was not associated with physical growth and body composition markers at 7 years old or with the velocity of their changes (p>0.05). There were significant interindividual differences in the trajectories of physical growth (height and body mass; p<0.001) and body composition (%Fat and Fat Free Mass; p<0.001). In plotting on international percentile charts, the trajectories of growth and body composition were within expected values for age and gender, regardless of birth weight. Conclusion There are significant differences in the dynamics of stature growth, body mass and Fat Free Mass, and Low Birth Weight has no influence on this trajectory. In addition, values are within the expected range for age and sex.

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“…Entre los más importantes cambios experimentados por la mayor parte de la población mundial a partir de la década de 1950 se encuentran las transiciones demográfica y epidemiológica y lo que se ha venido llamando "transición alimentaria", que en realidad es un estadio de la historia alimentaria de nuestra especie (Higuera Zazueta, 2011). Este estadio, de aumento en las enfermedades crónicas, tiene como característica principal una dieta energéticamente rica pero nutricionalmente pobre y bajos niveles de actividad física, resultado de un sedentarismo incrementado; las dos características anteriores se expresan, entre otras cosas, en el tamaño y composición corporales (Popkin et al, 1996) y en riesgos a la salud a mediano y largo plazo (Hoffman, 2014;Ulijaszek et al, 2012). México y Yucatán están inmersos en este estadio, lo que se refleja en elevadas tasas de sobrepeso y obesidad no sólo en adultos y adolescentes (OECD, 2015), sino también en niños (Mendez et al, 2015).…”

Section: Cambio Alimentariounclassified

¿Hijo de tigre, pintito? Algunos efectos intergeneracionales sobre la talla y el peso en niños mayas yucatecos

Dickinson¹,

Azcorra²,

Banik³

et al. 2018

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Growth retardation and metabolic programming: implications and consequences for adult health and disease risk

Cited by 15 publications

References 24 publications

Clonidine-stimulated growth hormone concentrations (cut-off values) measured by immunochemiluminescent assay (ICMA) in children and adolescents with short stature

Clonidine-stimulated growth hormone concentrations (cut-off values) measured by immunochemiluminescent assay (ICMA) in children and adolescents with short stature

Birth weight, physical growth and body composition in children: A longitudinal study

¿Hijo de tigre, pintito? Algunos efectos intergeneracionales sobre la talla y el peso en niños mayas yucatecos

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