Insulin resistance in obese children and adolescents

Romualdo, Monica Cristina dos Santos; Nóbrega, Fernando José de; Escrivão, Maria Arlete Meil Schimith

doi:10.1016/j.jped.2014.03.005

Cited by 71 publications

(56 citation statements)

References 23 publications

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“…Insulin resistance is an important condition that is associated with overweight and obesity, and studies have indicated that affected individuals exhibit a higher predisposition for the development of metabolic disorders in adulthood 1,6. An excess of body fat not only results in metabolic changes in adipose tissue and the induction of insulin resistance but also leads to endothelial dysfunction via pro-inflammatory and pro-thrombotic effects due to the action of pro-inflammatory cytokines and adipokines 7.…”

Section: Introductionmentioning

confidence: 99%

“…In Brazil, studies assessing cardiometabolic risk markers in overweight children and adolescents show high frequencies of changes in waist circumference (WC), blood pressure, dyslipidemia, insulin resistance and adipokine levels 6,9,10,11.…”

Section: Introductionmentioning

confidence: 99%

“…The search for effective measures to identify obese pediatric patients at a higher risk of developing metabolic and cardiovascular complications constitutes a promising strategy in the prevention of the comorbidities of early obesity 6. Therefore, the objective of the present study was to analyze the family history of excess body weight as well as the clinical, laboratory and adipokine markers of cardiometabolic risk and the occurrence of metabolic syndrome in overweight and obese children and adolescents recruited from public schools in a population study in the city of Uberaba, Minas Gerais, Southeast Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Palhares¹,

Silva²,

Resende³

et al. 2017

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OBJECTIVE:This study analyzed the frequency of cardiometabolic risk markers and metabolic syndrome occurrence in overweight and obese children and adolescents.METHODS:The participants included 161 overweight (n=65) and obese (n=96) individuals aged between 5 and 19 years. Clinical markers were assessed (body mass index, body fat percentage, waist circumference, acanthosis, systolic and diastolic blood pressures, laboratory parameters [glucose, insulin, cholesterol (total and fractions) and triglyceride levels and homeostasis model assessment of insulin resistance (HOMA-IR) index] and leptin and adiponectin levels). The frequency of changes, odds ratios and correlations among markers were determined. Metabolic syndrome was assessed according to International Diabetes Federation criteria.RESULTS:A high frequency of acanthosis (51.6%); increased waist circumference (45.4%), systolic blood pressure / diastolic blood pressure (8.1% / 9.3%), glucose (10%), insulin (36.9%) and HOMA-IR (44.3%) values; and reduced high-density lipoprotein levels (47.2%) were observed. Leptin levels were increased in 95% of obese and in 66% of overweight subjects. Adiponectin was decreased in 29.5% of obese and in 34% of overweight subjects. An odd ratio analysis revealed a greater probability of increased waist circumference (9.0), systolic blood pressure (4.1), triglyceride (2.3) and insulin (2.9) levels and HOMA-IR (3.0) in the obese group than in the overweight group. The clinical and laboratory parameters and leptin levels exhibited significant correlations, whereas adiponectin was negatively correlated with systolic blood pressure. The occurrence rate of metabolic syndrome was 13.6%.CONCLUSIONS:The high frequency of changes in clinical, laboratory and adipokine markers indicates the need for early interventions aimed at preventing cardiometabolic complications in adulthood.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Palhares¹,

Silva²,

Resende³

et al. 2017

Clinics

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show abstract

“…The homeostasis model assessment for insulin resistance was calculated based on the formula: HOMA-IR=insulin (mU/L)×glucose (mmol/L)/22.5, and we considered 3 as the cut-off value for the diagnosis of insulin resistance [28].…”

Section: Blood Collection and Biochemical Analysismentioning

confidence: 99%

Childhood adiposity: being male is a potential cardiovascular risk factor

et al. 2015

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“…[4][5][6] Indicators of body composition are strongly associated with metabolic changes, and it is important to verify their relationship with components of metabolic syndrome and with insulin resistance. 2,7,8 The body mass index (BMI) is the tool most commonly used to estimate overweight and obesity in children and adults. However, BMI has its limitations because increases may be related to increased fat-free mass.…”

mentioning

confidence: 99%

Waist circumference and insulin levels in obese children

Cempaka

Sidiartha

2017

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Background Childhood obesity is one of the most serious public health challenges of the 21st century. Its prevalence has increased at an alarming rate. Overweight and obese children are prone to obesity in adulthood and to developing non-communicable diseases (NCDs) like diabetes and cardiovascular diseases at a younger age. Increased waist circumference has been shown to contribute to the risk of metabolic syndrome in obese adults. Objective To assess for a correlation between waist circumference and insulin level in obese children. Methods In this cross-sectional study, obese children aged 6-10 years were included by consecutive sampling. We excluded children with infectious disease, malignancy, dyslipidemia, type 2 diabetes mellitus, or those who had not fasted before the blood draw. Subjects underwent waist circumference and fasting blood glucose measurements. Serum insulin levels were examined by enzyme-labeled chemiluminescent immunometric assay, after subjects had fasted for 10-14 hours. Data were analyzed by correlation analysis. Results Subjects had a mean waist circumference of 80.2 (SD 7.2) cm and mean insulin level of 10.70 (SD 7.5) µIU/mL . Pearson's correlation test revealed a significant, moderately positive correlation between waist circumference and elevated insulin level (r=0.45; P=0.006). Conclusion Waist circumference and insulin level have a significant, moderate, positive correlation in obese children. As such, waist circumference may be a simple method for early detection of hyperinsulinemia, as a risk factor for metabolic syndrome. [Paediatr Indones. 2017;57:194-7 ; doi: http://dx.doi.

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Insulin resistance in obese children and adolescents

Abstract: The results confirmed that insulin resistance is present in many obese children and adolescents, and that this condition is associated with alterations that represent an increased risk for developing metabolic disorders in adulthood.

Cited by 71 publications

References 23 publications

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Childhood adiposity: being male is a potential cardiovascular risk factor

Waist circumference and insulin levels in obese children

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