Association between morphometric variables and nocturnal desaturation in sickle-cell anemia

Salles, Cristina; Bispo, Marcelo; Trindade-Ramos, Regina Terse

doi:10.1016/j.jped.2014.01.005

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…(2014) 26 CC n=50 SS/50 AA (50 ♀/50 ♂); 9 m-15 y Lagos, Nigeria x̄ H (cm) H: SS 113.3/AA 115.4* Salles et al . (2014) 27 Co n=76 (non-apneic); x̄=9±3 y Salvador, Brazil x̄ H/A and BMI/A (Z/CDC) H/A=-0.7 (-1.4/-0.1); BMI/A=-1.0 (-2.2/-0.2) Akodu etal . (2012) 17 CC n=40 SS/40 AA; 2-15 y Lagos, Nigeria x̄ BMI/A (Z-WHO) ♀ SS -1.72/AA 0.03; p<0.001; ♂ SS -1.1/AA -1.01* Animasahun etal .…”

Section: Resultsmentioning

confidence: 99%

Características Socioeconômicas E Nutricionais De Crianças E Adolescentes Com Anemia Falciforme: Uma Revisão Sistemática

Jesus

Konstantyner

Lôbo

et al. 2018

Rev. paul. pediatr.

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Objective: To describe the socioeconomic and nutritional characteristics of children and adolescents with sickle cell anemia.Data sources: The present study is a systematic literature review based on published scientific articles. The searches were carried out using the electronic database of the National Library of Medicine, National Institutes of Health- PubMed. Two searches of articles published in the last 20years and without limitation of language were carried out. Thefirst one started from the Medical Subject Headings term “Anemia, Sickle Cell” associated with “Socioeconomic Factors”; and the second started from the term “Anemia, Sickle Cell” associated with “Anthropometry”. Thesearches were directed to research conducted on humans in the age group from 0 to 18years.Data synthesis: The final selection was composed by 11 articles on socioeconomic characteristics and 21articles on nutritional characteristics. Allstudies included children and adolescents with sickle cells disease (age range 0-18years), both genders, and most of them of black ethnicity. Families of children and adolescents with sickle cell anemia were of predominantly low socioeconomic status. Parents had lower educational levels when compared to parents of healthy children and adolescents. Body measurements (weight and height) and anthropometric indicators of children with sickle cell anemia were often lower when compared to healthy groups or reference populations.Conclusions: Children and adolescents with sickle cell anemia have socioeconomic limitations and worse nutritional conditions, when compared to reference populations. These limitations may lead to worse growth and greater occurrence of possible complications that can impair their quality of life.

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Section: Resultsmentioning

confidence: 99%

Características Socioeconômicas E Nutricionais De Crianças E Adolescentes Com Anemia Falciforme: Uma Revisão Sistemática

Jesus

Konstantyner

Lôbo

et al. 2018

Rev. paul. pediatr.

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“…In a clinical study including subjects with SCD, Salles et al found a positive correlation between height/age z score and cervical circumference. 116 The presence of nocturnal oxygen desaturation was associated with cervical circumference and abdominal circumference. There was a negative correlation between oxygen desaturation and maxillary intermolar distance and mandibular intermolar distance, ie, in SCD subjects that exhibited nocturnal oxygen desaturation, smaller maxilla, and mandible measurements were noted (measured using cephalometry, not MRI).…”

Section: Mri Of the Upper Airwaycomparison Between Healthy Controls Amentioning

confidence: 94%

“…OSAS therefore appears to be four to six times more common in Black children than White children 37 and is particularly prevalent in those with SCD. Based on data available, in addition to adenotonsillar hypertrophy, differences in facial features and upper airway anatomical structure 50,115,116 probably play a role in the prevalence of OSAS.…”

Section: Sickle Cell Diseasementioning

confidence: 99%

<p>Sleep-disordered breathing and comorbidities: role of the upper airway and craniofacial skeleton</p>

Brennan

Kirkham

Gavlak

2020

NSS

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Obstructive sleep-disordered breathing (SDB), which includes primary snoring through to obstructive sleep apnea syndrome (OSAS), may cause compromise of respiratory gas exchange during sleep, related to transient upper airway narrowing disrupting ventilation, and causing oxyhemoglobin desaturation and poor sleep quality. SDB is common in chronic disorders and has significant implications for health. With prevalence rates globally increasing, this condition is causing a substantial burden on health care costs. Certain populations, including people with sickle cell disease (SCD), exhibit a greater prevalence of OSAS. A review of the literature provides the available normal polysomnography and oximetry data for reference and documents the structural upper airway differences between those with and without OSAS, as well as between ethnicities and disease states. There may be differences in craniofacial development due to atypical growth trajectories or extramedullary hematopoiesis in anemias such as SCD. Studies involving MRI of the upper airway illustrated that OSAS populations tend to have a greater amount of lymphoid tissue, smaller airways, and smaller lower facial skeletons from measurements of the mandible and linear mental spine to clivus. Understanding the potential relationship between these anatomical landmarks and OSAS could help to stratify treatments, guiding choice towards those which most effectively resolve the obstruction. OSAS is relatively common in SCD populations, with hypoxia as a key manifestation, and sequelae including increased risk of stroke. Combatting any structural defects with appropriate interventions could reduce hypoxic exposure and consequently reduce the risk of comorbidities in those with SDB, warranting early treatment interventions.

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“… 18 20 Among the other causes of SDB, obesity, craniofacial malformations, neurological diseases, and gastroesophageal reflux disease stand out. 19 21 22 …”

Section: Discussionmentioning

confidence: 99%

“… 6 11 18 However, it is possible that this occurs due to other reasons relating to SCD, because obstructive sleep apnea syndrome has a multifactorial etiology. 19 21 22 …”

Section: Discussionmentioning

confidence: 99%

Adenotonsillar Hypertrophy in Pre-School Children with Sickle Cell Disease and Diagnostic Accuracy of the Sleep Disturbance Scale for Children

Góis

D’Ávila

Cipolotti

et al. 2017

Int Arch Otorhinolaryngol

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Introduction Adenotonsillar hypertrophy is more common in children with sickle cell disease, and can lead to sleep-disordered breathing. Objectives To determine the frequency of adenotonsillar hypertrophy in pre-school children with sickle cell disease and assess the diagnostic accuracy of the sleep-disordered breathing subscale in the Sleep Disturbance Scale for Children. Method Observational study with a group of 48 children with sickle cell disease and a control group of 35 children without the disease. The children underwent oropharingoscopy and video nasal endoscopy. The parents and/or guardians answered the questions of the subscale. Results Adenotonsillar hypertrophy was observed in 25% of the children in the study group, and in 20% of the children in the control group, with no statistical difference between the groups. The subscale score ranged from 3 to 11 in both groups. There was a statistical significance in the study group. The average was 4.79 (standard deviation [SD] ± 2.50), with 4.19 (SD ± 1.72) among the children without adenotonsillar hypertrophy, and 6.5 (SD ± 3.40) among the children with adenotonsillar hypertrophy. There was also a statistical significance in the control group. The average was 5.23 (SD ± 2.81), with 4.44 (SD ± 2.2) among the children without adenotonsillar hypertrophy, and 7.87 (SD ± 2.89) among the children with adenotonsillar hypertrophy. Conclusion Adenotonsillar hypertrophy was not associated with sickle cell disease in pre-school children. The subscale of sleep-disordered breathing in the Sleep Disturbance Scale for Children was a useful tool for the diagnostic suspicion of adenotonsillar hypertrophy in children in this age group.

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Association between morphometric variables and nocturnal desaturation in sickle-cell anemia

Abstract: the morphometric variables of CC and AC may contribute to raise suspicion of nocturnal desaturation in children and adolescents with sickle-cell anemia.

Cited by 9 publications

References 17 publications

Características Socioeconômicas E Nutricionais De Crianças E Adolescentes Com Anemia Falciforme: Uma Revisão Sistemática

Características Socioeconômicas E Nutricionais De Crianças E Adolescentes Com Anemia Falciforme: Uma Revisão Sistemática

<p>Sleep-disordered breathing and comorbidities: role of the upper airway and craniofacial skeleton</p>

Adenotonsillar Hypertrophy in Pre-School Children with Sickle Cell Disease and Diagnostic Accuracy of the Sleep Disturbance Scale for Children

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