Non-specific colitis among patients with colitis: frequency and relation to inflammatory bowel disease, a prospective study

Emara, Mohamed H; Salama, Rasha I.; Hamed, Emad F; Shoriet, Hebatalla Nabil; Abdel-Aziz, Hesham R.

doi:10.1016/j.jcol.2019.06.004

Cited by 6 publications

(4 citation statements)

References 6 publications

(20 reference statements)

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“…The expertise of the operator of both endoscopist and pathologist, the instruments, size of the samples, the timing for biopsy, and reference of the clinical data submitted to the pathologist, were the affecting factors. 13,15 In this study, patients with histopathological results of NSCC mostly came with chronic diarrhea without hematochezia. In contrast with a study from Moussa et al, the majority of NSCC histopathology findings admitted due to chronic diarrhea accompanied by hematochezia.…”

Section: Discussionmentioning

confidence: 86%

Colonoscopy and Histopathologic Features in Chronic Diarrhea Patients at Dr. Hasan Sadikin General Hospital Bandung

Rasdianto

Nugraha

Usman

et al. 2022

InaJGHE

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Background: Diagnosis and treating patients with chronic diarrhea are challenging due to broad differential diagnoses. An adequate examination leads to a specific diagnosis and appropriate management. Colonoscopy with biopsy is indicated to establish chronic diarrhea etiologies. No previous data demonstrated the colonoscopy and histology findings in patients with chronic diarrhea at Dr. Hasan Sadikin Bandung General Hospital, the main referral hospital in West Java. This study aims to determine the features of colonoscopy and histology in patients with chronic diarrhea.Method: This was a cross-sectional, descriptive study from secondary data of colonoscopy examinations at Dr. Hasan Sadikin Hospital General Hospital from 2016 to 2019. The inclusion criteria were patients with chronic diarrhea diagnosis, aged 18 years and over, and completed colonoscopy and biopsy results.Results: A total of 182 subjects with chronic diarrhea were included. Most subjects were women (52%) with an average age of 46 years. The clinical finding at admission was chronic diarrhea without hematochezia (75%). Meanwhile, 52% of colonoscopy lesions were multiple, with the anal-rectum segment (15%) being the most involved. Colonoscopy features mostly hyperemic or edematous lesions (58%). The histopathological result from this study revealed that 59% were non-specific chronic colitis (NSCC). Specific histopathological features were primarily found in malignancies (14%), and inflammatory bowel disease (12%).Conclusion: Chronic diarrhea without hematochezia was the most common objective for referring patients to colonoscopy. The hyperemic mucous lesion was mostly found. Moreover, the NSCC was frequent in histopathological evaluation, followed by malignancies and IBD.

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Section: Discussionmentioning

confidence: 86%

Colonoscopy and Histopathologic Features in Chronic Diarrhea Patients at Dr. Hasan Sadikin General Hospital Bandung

Rasdianto

Nugraha

Usman

et al. 2022

InaJGHE

View full text Add to dashboard Cite

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“…In addition, they followed up the patients with NSC for 6 months and reexamined 6 patients owing to persistence of symptoms by colonoscopy and found they had florid IBD on rebiopsy. 15 In our study, we could not determine whether the patients in the NSC group are normal or have another specific diagnosis because we did not follow-up these patients after biopsy.…”

Section: Discussionmentioning

confidence: 88%

“…A recent study in 2019 by Emara and colleagues evaluated prospectively 80 patients with clear indications for colonoscopy including IBS and non-IBS cases after excluding those with known specific colitis (infection or IBD) or colonic malignancy and found that 67 patients (83.75%) had NSC. In addition, they followed up the patients with NSC for 6 months and reexamined 6 patients owing to persistence of symptoms by colonoscopy and found they had florid IBD on rebiopsy 15. In our study, we could not determine whether the patients in the NSC group are normal or have another specific diagnosis because we did not follow-up these patients after biopsy.…”

Section: Discussionmentioning

confidence: 88%

Prevalence of Microscopic Colitis in Diarrhea-predominant Irittable Bowel Syndrome Patients

Ebeid¹,

Eid²,

Attia³

et al. 2021

Journal of Clinical Gastroenterology

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Background and Aim: There is controversy about colonoscopy and taking biopsy from the normal colonic mucosa in patients with a clinical diagnosis of diarrhea-predominant irritable bowel syndrome (D-IBS). This study aims to estimate the prevalence of microscopic colitis (MC) in D-IBS patients and to select patients without the well-known alarming features who will benefit from colonoscopy and biopsies from the normal colonic mucosa. Patients and Methods: We performed a cohort cross-sectional study over 6 months duration in a total of 129 patients with Rome III criteria of D-IBS after excluding cases with features of organic diseases. Cases were subjected to colonoscopy and biopsies from the colonic mucosa that seemed normal. Results: Histopathologic examination of biopsies taken from cases with normal colonic mucosa revealed 86 (71.66%) cases with nonspecific colitis, 26 (21.66%) cases with MC and 8 (6.66%) cases with ulcerative colitis. Concomitant immunologic diseases (P=0.00005) and triggering drugs intake (P=0.006) were significantly more common in the MC group. The mean duration of diarrhea in MC patients was significantly longer than that of nonspecific colitis and ulcerative colitis patients (P=0.0006). Conclusions: Prevalence of MC in D-IBS patients from Upper Egypt is relatively high (21.66%). Concomitant immunologic diseases, possible triggering drugs intake, and long duration of diarrhea are significant risk factors for undiagnosed MC in D-IBS patients.

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“…The term of non-specific colitis refers to inflammation in colon that microscopically does not have characteristic features of any specific form of colitis and usually found in pathology report from colonoscopy biopsy. This term is used for colonic inflammation that does not have specific pathological features from common cause of colitis (Emara et al, 2019). In this study, the samples with the lymphoid aggregate features and erosion on the surface epithelium were included into the non-specific colitis interpretation.…”

Section: Methodsmentioning

confidence: 99%

Variation of histopathological features in colonic mucosal biopsy with clinical diagnosis of suspicious inflammatory bowel disease in Dr. Soetomo General Academic Hospital, Surabaya period 2015 - 2019

Pasang

Rahniayu

Rahaju

2022

ijhs

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Inflammatory bowel diseases (IBDs) are chronic inflammatory diseases that often relapse and divided into two types, Crohn’s disease (CD) and ulcerative colitis (UC). Histopathological findings in colonic mucosal biopsy with clinical diagnosis suspicious IBD can vary and overlap. Therefore, criteria and guidelines have been created to improve the diagnostic accuracy. This descriptive observational study was performed retrospectively with cross sectional approach. 122 samples of colonic mucosal biopsies with clinical diagnosis of suspicious IBD were retrieved from histopathological archives in the Anatomical Pathology Laboratorium of Dr. Soetomo Hospital, Surabaya during period 1st January 2015 - 31st December 2019. The most common histopathological feature found in colonic mucosal biopsies with clinical diagnosis of suspicious IBD was crypt distortion (97/79.50% samples), and the least was irregularity of surface epithelium (30/24.59% samples). 10 of 122 samples was concordant with the final diagnosis of IBD. Knowledges regarding the variations of histopathological features in colonic mucosal biopsy specimens with clinical diagnosis of suspicious IBD, can improve the diagnostic accuracy.

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Non-specific colitis among patients with colitis: frequency and relation to inflammatory bowel disease, a prospective study

Cited by 6 publications

References 6 publications

Colonoscopy and Histopathologic Features in Chronic Diarrhea Patients at Dr. Hasan Sadikin General Hospital Bandung

Colonoscopy and Histopathologic Features in Chronic Diarrhea Patients at Dr. Hasan Sadikin General Hospital Bandung

Prevalence of Microscopic Colitis in Diarrhea-predominant Irittable Bowel Syndrome Patients

Variation of histopathological features in colonic mucosal biopsy with clinical diagnosis of suspicious inflammatory bowel disease in Dr. Soetomo General Academic Hospital, Surabaya period 2015 - 2019

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