Effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat

Abstract

Ulcerative colitis is a chronic inflammatory condition of the colon with an unknown etiology. In this study, we aimed to evaluate the therapeutic effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat. Fifty-five male rats divided into five equal treatment groups were used for this study and received the following treatments: Group 1, 250 mg/kg asacol; Group 2, 1 ml gel base (carboxymethyl cellulose); Group 3, 0.5% gel form of C. sempervirens extract; Group 4, 1% gel form of C. sempervirens extract, and; Group 5, considered as negative control and received 1 ml of normal saline. Body weight changes, histopathological and antioxidant changes in the colon tissue were evaluated. Significant weight gain was observed in rats that received 1% gel extract of C. sempervirens . Significant superoxide dismutase activity was also detected in 0.5 and 1% gel extract groups compared to C. sempervirens extract, Asacol and in 1% gel extract groups compared to the gel base group. Furthermore, both gel extract groups had significant lower total antioxidant capacity compared to Asacol group. Several histopathological lesions including inflammation, ulceration, crypt disarray, and goblet cell depletion were detected in the different groups, however, the mean rank of pathological changes showed no significant difference among the five groups. In summary, our results showed that hydroalcoholic extracts of C. sempervirens leaves produces healing effects in acetic acid induced ulcerative colitis.

Effects of Fresh <i>Cupressus sempervirens</i> Leaves Infusion on Growth Performance, Intestinal Microbiota and Haemato-Biochemical Parameters in Broilers

“…These results are in line with the findings of [29] who reported that 50 ml of ginger extract per litre of drinking water significantly improved the final live weight and weekly weight gain of broilers; and the results of [30] who reported a significantly positive effect on the weight gain of rats fed with Cupressus sempervirens extaits. This beneficial effect of live weight and weight gain with this phytobiotic in drinking water was explained by the presence of phenolic, terpenoic, and alkaloid compounds that are also present in Cupressus sempervirens.…”

Gallincin ameliorates colitis-associated inflammation and barrier function in mice based on network pharmacology prediction

“…In fact, this is not the first study to show colorectal barrier dysfunction in experimental colitis, as intestinal barrier damage has also been observed in other colitis models. [29][30][31][32] Schmitz et al 33 reported that the inflamed intestinal mucosa observed with UC exhibited impaired barrier function; altered TJ structures contributed to this barrier defect. Disruption of the TJ structure has been recognized as a potential cause or result of disease.…”

Targeting inflammation and oxidative stress for protection against ischemic brain injury in rats using cupressuflavone

“…In contrast, CUP-treated rats showed significantly enhanced GSH brain content and CAT activity, and significantly decreased MDA levels. In addition to its anti-apoptotic activity, Koriem et al and Sepehrimanesh et al ( Koriem et al, 2015 , Sepehrimanesh et al, 2018 ) reported that CUP presumably suppresses gastrointestinal disorders (gastric ulceration and ulcerative colitis) by enhancing endogenous antioxidant enzymes and eliminating free radicals.…”