Rectal cancer survival in a Brazilian Cancer Reference Unit

Corrêa, Romualdo da Silva; Pinto, Francisco Edilson Leite; Santos, Lucas Vinícius Silva dos; Góis, Mariana Carlos de; Silva, Rumenick Pereira da; Silva, Hylarina Montenegro Diniz

doi:10.1016/j.jcol.2016.04.015

Cited by 9 publications

(9 citation statements)

References 8 publications

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“…LOX was separated and purified in several steps as shown in the Table (1). The first step was precipitating and separating the enzyme from blood serum by using ammonium sulphate salt at a concentration (0-40)%.…”

Section: Separation and Purification Of Lox From Serum Patients Of Colon Cancermentioning

confidence: 99%

Estimating Lipoxygenase and Gamma-glutamyl Transferase Activities in Sera of Colon Cancer Patients with Partial Purification of Lipoxygenase

Al-Adlee

2020

Baghdad Sci.J

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Colon cancer is an abnormal growth of cells that occurs in the large intestine. Sometimes growth remains restricted for a relatively long time before it becomes a malignant tumor and then spreads through the intestinal wall to the lymph nodes and other parts of the body. The study aims to estimate the effectiveness and partial purification of lipoxygenase (LOX) enzyme and measure gamma-glutamyle transferase (GGT) activity in serum patients of colon cancer in Baghdad. The study included (80) case male patients with colon cancer with (50) samples of apparently healthy males (control) as comparison group. The result displayed a noteworthy increase in lipoxygenase effectiveness (805.0±517.23 IU/L) in serum of patients with colon cancer compared with control (114.6±49.77 IU/L). The enzyme was purified by the precipitation of the serum protein using (40% (NH4)2SO4) then removing the remaining salts by dialysis. The column of gel (sephadex G.100) was used to separate the enzyme from another protein, in this step a single peak was obtained. The effective part of lipoxygenase at yield (71.42%) and folds (11.033). The ion exchange chromatography (DEAE–CeA50) was used to isolate LOX isoenzyme, two bands (LOX1 and LOX2) were acquired with different degree of purity (16.372) and (12.16) folds respectively. The result displayed a noteworthy increase in the (GGT) activity in patients (58.69±16.94IU/L) (probability P≤ 0.000) compared with control (12.79±5.68 IU/L). The increase in activity of LOX can be used as a tumor marker to detect the colon cancer disease.

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Section: Separation and Purification Of Lox From Serum Patients Of Colon Cancermentioning

confidence: 99%

Estimating Lipoxygenase and Gamma-glutamyl Transferase Activities in Sera of Colon Cancer Patients with Partial Purification of Lipoxygenase

Al-Adlee

2020

Baghdad Sci.J

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“…Colorectal cancer (CRC) is one of the most common cancers worldwide with 1 million new cases a year [1]. From the epidemiological point of view, the right colon extends to the splenic fissure, as well as to the left colic angle (without including it) and the left colon extends from the left colic angle to the-sigmoid hinge [2].…”

Section: Introductionmentioning

confidence: 99%

Colorectal Cancers Screening in the General Population: Focusing

Elhabachi¹,

Brahim

2019

Mèd Technologies J.

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Colorectal cancers are common throughout the world, although their incidence varies across continents and countries. 28% of these cancers are rectal and two-thirds of the remaining 72% are of left colonic location. Screening and prevention have proven effective in reducing the incidence of these cancers and their mortality. The best screening results in the so-called average-risk general population have been obtained in the USA, where first-line endoscopy is the gold standard when in other countries, especially European ones; screening was done by the search for occult blood in the stool. This group, however, became heterogeneous due to the intervention of environmental factors and co-morbidities; a colonoscopy is then proposed to those subjects considered at average risk. Virtual colonoscopy has excellent sensitivity and specificity for one centimeter polyps. The serrated polyps, pre-cancerous lesions predominating on the right, are more difficult to detect.

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“…Even so, there are few studies in Brazil that evaluate the 5-year populational cancer survival. The available studies show survival data based on patients managed at some hospitals that are cancer reference units, though these studies are not population-based (Ayala, 2012;Brito et al, 2009;Carneseca et al, 2013;Corrêa et al, 2016). This paper intends to present 5-year survival estimates by using the methodology of the mortality to incidence ratio (M:I) for the most recent years available on the official information systems, covering the first decade of the 21st Century.…”

Section: Introductionmentioning

confidence: 99%

Cancer survival in Brazil: Estimate through the mortality to incidence ratio

Reis¹,

Scaff²

2018

J. Public Health Epidemiol.

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Information about cancer incidence, mortality and survival is one of the pillars for disease monitoring. In Brazil, only a few studies show population-based survival. The mortality to incidence ratio (M:I) is an indirect measure of cancer survival and can be used to estimate a population cancer survival. To calculate the mortality to incidence ratios (M:I), an official information for incidence and mortality rates in Brazil during 2002 to 2014 was used. A complement to the age-adjusted cancer mortality to incidence ratios [1-(M:I)] as a 5-year survival estimate for all cancers, excluding non-melanoma skin, breast, lung, prostate, cervical, colo-rectal and stomach cancers were calculated. The median survival estimate for all tumors was 52% for males and 56% for females. The lowest survival estimates, in both sexes, can be observed in North and Northeast regions for lung and stomach cancer. For colo-rectal cancer, the survival estimates were similar for both sexes, varying between 50 and 65%. Prostate and breast cancer had the highest survival estimates (79 and 74%, respectively). The survival estimate for cervical cancer in Brazil was 64%. Despite the limitation, the study showed that the methodology can be a simple predictor for calculating 5-year survival rates.

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Rectal cancer survival in a Brazilian Cancer Reference Unit

Cited by 9 publications

References 8 publications

Estimating Lipoxygenase and Gamma-glutamyl Transferase Activities in Sera of Colon Cancer Patients with Partial Purification of Lipoxygenase

Estimating Lipoxygenase and Gamma-glutamyl Transferase Activities in Sera of Colon Cancer Patients with Partial Purification of Lipoxygenase

Colorectal Cancers Screening in the General Population: Focusing

Cancer survival in Brazil: Estimate through the mortality to incidence ratio

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