Background: The progress of scientific research gives new tracks to be exploited for the management of the colorectal cancers whose the molecular profile study became fundamental. Aim: the aim of this study was to compare the management of the colorectal cancer in our patients to the current international recommendations. Subjects and methods: In a retrospective study, we analysed 256 files between January, 2015 and September 2019. All the adenocarcinoma of colon and rectum were included. Our patients were divided into two groups: 161 patients with colorectal cancer (63%) and 95 patients with rectum cancer (37%). We studied if the management of the disease was actually compliant to the international recommendations. Results: Our study showed that the colorectal cancer occured most frequently in young population, with 45,5% in patients aged more than 60 years, 44% between 40 -60 years and 10 were under 40 years. The tumor was in T3 or more stage in 40,3% for colon cancer and 68,4% for rectum cancer. Elsewhere, none of the patients benefited from a molecular profile study of his tumor. Discussion:The colorectal cancer is diagnosed in relatively young population with 54,5% of patients aged less than 60 years among whom 10% are less than 40, which explains the diagnostic delay. This delay is also due to the lack of a screening in general population and high risk subjects. Moreover, the absence of a molecular examination has a negative impact on the treatment and on the screening in the apparented, especially in case of tumor with micro satellite instability. Conclusion: In order to improve the prognosis of the colorectal cancers in our patients, a screening adapted to the groups at risk has to be implemented and a molecular profil examination achived so that evolution and therapeutics perspectives could be set.
Introduction: Colorectal cancers rank third in all cancers. Mass screening has proven effectiveness by significantly reducing incidence and mortality. If optical colonoscopy is the reference exam, virtual colonoscopy is an alternative of choice. We evaluate its first-line position in screening, following technological progress. Methods: We used PubMed's electronic search data from 2010. Among the 100 most consulted articles, have been studied those in English-language and which looked at screening in the population at average risk aged between 50 and 75 years , asymptomatic and dealing with optical and virtual colonoscopy. Studies in the symptomatic, high-risk, or very high-risk population or for diagnostic purposes were excluded. Results: in the USA, studies confirm the trend towards a decrease in incidence and mortality by colorectal cancers, shifting from 56.7 per 100,000 and 23.6 deaths respectively in 1992 to 36.5 per 100,000 and 14 deaths in 2015, thanks to the means of screening including the endoscopy. Although optical colonoscopy is the standard exam, virtual colonoscopy, with a specificity of 90% and a sensitivity of 85%, is becoming more and more a first-line means of screening for colorectal cancers. Conclusion: Thus, first-line endoscopic screening has proved its effectiveness in reducing morbidity and mortality by this cancer. However, the virtual endoscopy chosen by the National Comprehensive Cancer Network as a means of screening will undoubtedly constitute a strategy for the future, particularly in developing countries.
Colorectal cancers are common throughout the world, although their incidence varies across continents and countries. 28% of these cancers are rectal and two-thirds of the remaining 72% are of left colonic location. Screening and prevention have proven effective in reducing the incidence of these cancers and their mortality. The best screening results in the so-called average-risk general population have been obtained in the USA, where first-line endoscopy is the gold standard when in other countries, especially European ones; screening was done by the search for occult blood in the stool. This group, however, became heterogeneous due to the intervention of environmental factors and co-morbidities; a colonoscopy is then proposed to those subjects considered at average risk. Virtual colonoscopy has excellent sensitivity and specificity for one centimeter polyps. The serrated polyps, pre-cancerous lesions predominating on the right, are more difficult to detect.
Background:Acute inflammation of the pancreas, acute pancreatitis (AP) shows an increasing incidence in the world as well as in Algeria. However, lethality and mortality are decreasing, mainly due to recommendations from Atlanta, the International Pancreatology Association and the American Pancreatology Association. The purpose of this work was to analyze the management of AP in the general surgery department of the UHC of Sidi Bel Abbes. Method: In a retrospective study, 100 acute pancreatitis cases admitted to general surgery between January 2017 and December 2019 were analyzed. The abdominal scanner was systematic at the admission. The rate of lipasemia, when greater than 3 times the normal one, allowed, in association with the evocative pain, to make the diagnosis. The severity of AP was assessed using the Balthazar score. An MRI was requested when the scanner was inconclusive, to look for an etiology and / or possible complications. 79 (79%) patients received broad-spectrum antibiotic therapy and diet was systematic. Results: We have transmitted the recommendations of scholar societies to the various specialists and the management of AP is currently more unified and more effective. Scanner is no longer systematic in the early phase. Antibiotic therapy is no longer administered without biological evidence. Enteral nutrition is now possible. Conclusion: We were able to reach the goal of reducing hospitalization and scanning requests. A further analysis of 100 other PA files is planned to confirm the obtained results.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.