Validation of blood components transport through a pneumatic tube system

Garcia, Lucas França; Speransa, Daniela Michelim Rodriguez; Rodrigues, Cristiane Braga; Benites, Rosimari Melgarejo; Garcia, Mariana Timm; Sekine, Leo; Franz, Juliana Pires Marafon

doi:10.1016/j.htct.2021.07.010

Cited by 7 publications

(23 citation statements)

References 9 publications

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“… 33 Before transporting apheresis platelet concentrates via the PTS, acceleration forces should be measured at each facility and validation using a quality threshold should be performed. 9 , 19 , 34 An appropriate study design for this is provided by Garcia et al 35 or by Stangerup et al 36 who performed a 5‐day validation using mini data logger.…”

Section: Discussionmentioning

confidence: 99%

Triple apheresis platelet concentrate quality after pneumatic tube system, conveyor box, and courier transport: An observational study

Reichert

Wallner

Burkhardt

et al. 2022

Health Science Reports

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Background and Aims Platelets are prone to activation from handling; they are therefore transported as gently as possible, most commonly by courier. Speedier methods like pneumatic tube system (PTS) transport could improve patient care but may subject platelets to mechanical stress. To test the impact of mechanical stress caused by transport, we compared a PTS with a conveyor box and courier transport on apheresis platelet function. Methods Fourteen apheresis platelet concentrate triple donations were analyzed by light transmission aggregometry (LTA), rotational thrombelastometry (ROTEM), and flow cytometry before and after indoor transport over 800 m by PTS, conveyor, and courier, respectively, while recording shocks and vibrations with a high‐frequency acceleration data logger. Shock index scores were calculated as shock intensity (g‐force) times frequency. Results The shock index was 81 for courier, 6279 for conveyor, and 9075 for PTS. Flow cytometry revealed no significant difference in platelet surface expression of CD62p before (16%) and after transport via courier (15%), conveyor (14%), or PTS (16%). LTA with adenosine phosphate and thrombin receptor‐activating peptide‐6 resulted in comparable platelet aggregation for courier, conveyor, and PTS. ROTEM assays showed no relevant differences in coagulation time, clot formation time, and maximum clot firmness between transport modes. Conclusion Though the mechanical challenge was smallest with courier transport, there were no significant differences in platelet activation or aggregation between the three transport modes. These data contradict restrictions on the use of PTSs for platelet concentrate transport.

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Section: Discussionmentioning

confidence: 99%

Triple apheresis platelet concentrate quality after pneumatic tube system, conveyor box, and courier transport: An observational study

Reichert

Wallner

Burkhardt

et al. 2022

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…Despite that, the ndings are seldom related to any clinical signi cance. In addition, Garcia et al (2021) analyzed hemoglobin and hemolysis index. It demonstrates that both transport routes exhibited no signi cant difference between pre-and post-transport values for hemoglobin and hemolysis index.…”

Section: Methodsmentioning

confidence: 99%

“…From the 12 evaluated studies that deal with clinical chemistry parameters, four studies [1,8,10,11] suggest that there is a clinically signi cant difference between the levels of Lactate Dehydrogenase on blood samples transported through PTS and manual transport, with a p-value of 0.001, < 0.0001, 0.000, and < 0.01 respectively. On the other hand, ve studies [5,6,7,9,15] stated that there is no clinically signi cant difference between samples transported with the use of PTS and manual transport, with a pvalue of 0.666, 0.4819, 0.6, 0.218, and 0.648 consecutively. The PTS used has a varying length from 42.6 to 1,423m with a speed ranging from 2 to 10.9 m/s, whereas one study [11] did not report the length nor the speed of the PTS utilized.…”

Section: Study Selection and Excluded Studiesmentioning

confidence: 99%

“…Lastly, Garcia et al (2021) evaluated the use of PTS transportation on blood components, namely Packed Red Blood Cells (PRBCs), Thawed Fresh Plasma (TFP), Cryoprecipitate (CR), and Platelet concentrate (PC), and compared it to courier transportation. A total of 23 PRBCs, 50 units of TFP, 30 units of CR, and 10 units of PC were assessed.…”

Section: Blood Chemistrymentioning

confidence: 99%

“…However, one study [13] has not reported the p-value but indicated that potassium levels had no signi cant impact on PTS transport. On the other hand, nine studies [1,2,5,6,8,9,10,13,15] have speed ranges from 3 to 13 m/s, and two studies [4,11] have not reported such characteristics. In addition, each study used a different length of PTS, the nine studies reported the following length of the PTS: 170 m, 250 m, 6.096 m, 463 m, 73-297 m, 42.6-1, 423 m, 106 m, 106 m, and 685 m, respectively.…”

Section: Potassium (K)mentioning

confidence: 99%

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A Systematic Review of the Impact of Pneumatic Tube System Transport on Blood Chemistry and Hematology Parameters

Ausmolo

Pua

Abiog

et al. 2022

Preprint

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Introduction: Today, many hospitals use a Pneumatic Tube System (PTS) to quickly convey specimens to the lab. This study examined the clinical and practical impacts of PTS in delivering specimens. Blood chemistry and hematologic parameters were compared between PTS and manual transfer to determine whether there was a significant increase or decrease in its values. The study evaluated the following Blood Chemistry parameters such as LDH, K, AST, ALP, ALT, and Total Bilirubin and Hematologic parameters such as Red Cell indices (MCV, MHC, and MCHC), RBC count, Hemoglobin and Hematocrit, Hemolysis rate, and Platelet count. The data are gathered to evaluate if PTS provides the same specimen integrity as the manual technique. In this project, the researchers will conduct a systematic review utilizing the PRISMA 2020 reporting checklist. Methodology: Studies obtained from online databases were utilized. A set of criteria for selecting prospective studies were established. The studies should be published from 2017 to October 2022, must assess the effects of PTS by comparing them to manually transported samples, and must be fully accessible. Subgroup analysis and cumulative analysis were conducted to establish transparency of the results. Findings and Discussion: A total of 27 studies were evaluated. Among these, 13 of the studies included are for blood chemistry and 15 studies are for hematology. Among all the parameters evaluated, only LDH, potassium, and Hemolysis index showed clinical significance between the samples transported via PTS and manually delivered. The other chemistry parameters were also increased but were not clinically significant. Whereas, Hematologic parameters have only limited studies available that can show that it is of clinical significance. However, most included studies utilized a small sample size and limited population, restricting further analysis of obtained results. Additionally, some were hindered due to insufficient data and information. Moreover, the technical aspects that can cause the results to differ are not provided because the PTS utilized to modify acceleration and deceleration, are not sufficiently described. Some research claimed that their study was restricted to PTS effects alone.

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Study on friction and conveying characteristics of the pneumatic logistics transmission system

Ruan

Guo

et al. 2023

Powder Technology

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Validation of blood components transport through a pneumatic tube system

Cited by 7 publications

References 9 publications

Triple apheresis platelet concentrate quality after pneumatic tube system, conveyor box, and courier transport: An observational study

Triple apheresis platelet concentrate quality after pneumatic tube system, conveyor box, and courier transport: An observational study

A Systematic Review of the Impact of Pneumatic Tube System Transport on Blood Chemistry and Hematology Parameters

Study on friction and conveying characteristics of the pneumatic logistics transmission system

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