COVID-19 and thrombotic thrombocytopenic purpura: A review of literature

Singh, Balraj; Kaur, Parminder; Mekheal, Erinie; Fasulo, Sydney M.; Maroules, Michael

doi:10.1016/j.htct.2021.06.009

Cited by 5 publications

(6 citation statements)

References 10 publications

(6 reference statements)

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“…Hematologic abnormalities such as poikilocytosis, anemia, and thrombocytopenia may occur in COVID-19 patients. [11] Erythrocyte morphology in the peripheral blood smear of the patient who participated in this study showed some mushroom-shaped red cells in addition to numerous schizocytes. This finding has been previously reported in the literature.…”

Section: Discussionmentioning

confidence: 64%

“…Many factors can trigger acquired TTP, including inflammatory diseases, medications, and pregnancy after allogeneic hematopoietic stem cell transplantation. [ 8 , 11 ] In addition, acute infections are a well-known, well-established trigger for acquired TTP. [10]…”

Section: Discussionmentioning

confidence: 99%

“…Due to the prolonged onset of action of rituximab, plasma exchange must be continued until the drug takes effect. [18] In turn, Singh et al [11] showed that the use of caplacizumab (10 mg for 4 weeks), a humanized single variable domain immunoglobulin (nanobody) against VWF, resulted in complete clinical remission of TTP in an adult female patient (44 years) with COVID -19.…”

Section: Discussionmentioning

confidence: 99%

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Thrombotic thrombocytopenic purpura and mushroom-shaped red blood cells secondary to COVID-19: A case report

Borborema

Lima

Brito

et al. 2023

Hematology, Transfusion and Cell Therapy

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Thrombotic thrombocytopenic purpura and mushroom-shaped red blood cells secondary to COVID-19: A case report

Borborema

Lima

Brito

et al. 2023

Hematology, Transfusion and Cell Therapy

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“…Among these forms of TMA, TTP and DIC have been reported in COVID−19 patients. 57 58 The incidence of DIC is higher in COVID compared to other respiratory infections, and the mechanism seems to be different from the typical DIC associated with other illnesses. 43 57 On brain imaging, multifocal small-vessel cortical and subcortical infarcts and hemorrhages as well as posterior reversible encephalopathy syndrome (PRES) are the most common findings, but rarely large-vessel infarcts or large intraparenchymal hematomas can occur.…”

Section: Vascular Inflammatory Conditions and Coagulopathymentioning

confidence: 99%

“…Among these forms of TMA, TTP and DIC have been reported in COVIDÀ19 patients. 57,58 The incidence of DIC is higher in COVID Fig. 4 Total spine MRI of an 18-year-old man with headache, urinary retention, bowel retention, neck rigidity, and lower extremity weakness 8 days after COVID diagnosis.…”

Section: Small-vessel Ischemic Disease and Microhemorrhagementioning

confidence: 99%

Neuroimaging of COVID-19

Kim

Young

2023

Semin Neurol

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We review the wide variety of common neuroimaging manifestations related to coronavirus disease 2019 (COVID-19) and COVID therapies, grouping the entities by likely pathophysiology, recognizing that the etiology of many entities remains uncertain. Direct viral invasion likely contributes to olfactory bulb abnormalities. COVID meningoencephalitis may represent direct viral infection and/or autoimmune inflammation. Para-infectious inflammation and inflammatory demyelination at the time of infection are likely primary contributors to acute necrotizing encephalopathy, cytotoxic lesion of the corpus callosum, and diffuse white matter abnormality. Later postinfectious inflammation and demyelination may manifest as acute demyelinating encephalomyelitis, Guillain–Barré syndrome, or transverse myelitis. The hallmark vascular inflammation and coagulopathy of COVID-19 may produce acute ischemic infarction, microinfarction contributing to white matter abnormality, space-occupying hemorrhage or microhemorrhage, venous thrombosis, and posterior reversible encephalopathy syndrome. Adverse effects of therapies including zinc, chloroquine/hydroxychloroquine, antivirals, and vaccines, and current evidence regarding “long COVID” is briefly reviewed. Finally, we present a case of bacterial and fungal superinfection related to immune dysregulation from COVID.

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