Background
Ever since the administration of early doses of COVID-19 vaccines, instances of adverse effects have been reported. Viral infections, specifically herpes simplex reinfection and coinfections, have been reported following administration of different types of vaccines. To our knowledge, there have not been any reports of herpes simplex encephalitis following administration of any type of COVID-19 vaccine to date.
Case presentation
In this article intends to report a case of herpes simplex encephalitis in a 27-year-old male patient who was vaccinated with the ChAdOx1 nCoV-19 vaccine.
Conclusions
Our study suggests a possible but very rare side effect of ChAdOx1 nCoV-19 vaccine, which requires immediate medical attention and can lead to devastating consequences if left undiagnosed and untreated.
Cytokine storm is the most prominent hallmark in patients with coronavirus disease 2019 (COVID-19) that stimulates the free radical storm, both of which induce an overactive immune response during viral infection. We hypothesized that owning to its radical-scavenging and anti-inflammatory properties, Edaravone could reduce multi-organ injury, clinical complications, and mortality in severe COVID-19 cases. This single-center randomized clinical trial was accompanied in the intensive care units (ICUs) of the teaching hospital of Tabriz University of Medical Sciences to evaluate the effect of Edaravone on the outcome of patients with severe COVID-19. Thirty-eight patients admitted to ICU were included and randomized into two control and intervention arms. Patients in the intervention group received 30 mg Edaravone by slow intravenous infusion for three days in addition to receiving national therapy. The primary outcome was the need for intubation, the intubation length, and mortality rate. Secondary endpoints were clinical improvement. Edaravone administration improved the primary outcomes; it decreased the need for endotracheal intubation and mechanical ventilation [10.52% (
n
= 2) versus 42.1% (
n
= 8);
p
= 0.03] and intubation length [3 (1–7) versus 28 (4–28),
p
= 0.04] compared to control group. Baseline characteristics and laboratory tests were similar between the studied groups. No marked differences were observed in secondary endpoints (
p
> 0.05). Administration of Edaravone could decrease the need for mechanical ventilation and length of intubation in severe COVID-19 patients admitted to ICU.
Thromboembolic events have been reported in hospitalized patient since
beginning of the covid 19 pandemic. This study reports an ICU admitted
patient with lower extremity arterial thrombosis diagnosed with covid
19.
Due to advancements in instrumentation and communication technologies, monitoring of water infrastructure is experiencing a significant growth worldwide and water managers are increasingly deploying monitoring equipment for decision-making purposes. Hydrological events and relevant datasets including rainfall data are of a complex nature and are potentially susceptible to errors from various sources. Hence, it is essential to develop efficient methods for the quality control of the acquired data. The present work introduces an artificial neural network-based approach for real-time quality control and infilling of rain gauge data. Available rainfall measurements from neighboring rain gauges are employed to train and develop the neural network model. Trained artificial neural network model was able to validate up to about 97% of the data using 95% confidence intervals. This finding suggests that artificial neural networks can be successfully implemented for erroneous data identification/correction and reconstruction of missing data points. Given its short processing time and reportedly superior performance to traditional quality control strategies, neural network methodology can be deployed as an efficient tool for the processing and control of large sets of timeseries with complex natures including precipitation data.
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